COVID-19 research at ELHT

Health research is vital during the COVID-19 pandemic.

At East Lancashire Hospitals NHS Trust (ELHT) we are part of the national research effort to prevent, diagnose and treat COVID-19. The research is helping us to learn more about the illness, which people are most at risk, and what treatments benefit those affected. East Lancashire patients and our clinical and research staff are playing their part by supporting national, high-priority research studies within our hospitals. 

For an up to date summary of the COVID-19 research studies available at ELHT, please check the list below:

Research into other conditions

We're so grateful to all the East Lancashire patients who’ve volunteered to take part in health research. You join over 20,000 participants from our hospitals, who contribute to a better understanding of disease and finding new treatments.

In accordance with guidelines from the Department of Health and Social Care and the National Institute for Health Research, we temporarily paused the entry of new patients into the research studies that were taking place before the COVID-19 outbreak. This was to keep patients safe and to ensure that members of the research team were available to support clinical services and COVID-19 research.

Restarting research

Our efforts to tackle the pandemic continue but to advance care and treatment for East Lancashire patients across a range of health conditions, we are now restarting the research which was taking place prior to the COVID-19 outbreak. We are working closely with research sponsors to achieve this, and where clinical services are available for us to deliver the research.

Safety is our priority

The safety of patients and hospital staff is our top priority and we are following the Trust guidance for infection control and hospital appointments. This includes minimising footfall on the hospital site, maintaining social distancing and using decontamination procedures.

If you’re taking part in a research study

If you were taking part in a research study at the hospital before the COVID-19 outbreak, the study team will have contacted you to discuss any changes to your follow up appointments, or to your medication and how to collect this from the hospital. As we restart any research that was temporarily paused, the study team will continue to inform you of any changes that may affect you.

If you have any questions or concerns, please don’t hesitate to get in touch with your study team. Their contact details are as follows:

For women’s health research: 01282 803081
For children's research: 01254 732643
For cancer research: 01254 733299
For all other research: 01254 732756

To find out more about our research 

If you’d like to find out more about research at East Lancashire Hospitals, please visit the research pages of this website or you can also follow us on twitter @ELHTresearch. The Be Part of Research website also provides more information on research and lists the studies taking place in East Lancashire and nationally throughout the NHS.

Information for researchers and sponsors

The restart of research, which was taking place in the Trust before the COVID-19 pandemic, is happening in a phased approach according to the prioritisation levels published in the National Institute for Health Research (NIHR) Restart Framework. 

The prioritisation levels are as follows:

  • Level 1: COVID studies with Urgent Public Health (UPH) status
  • Level 2: Non-COVID studies where patient safety may be compromised in not continuing or re-opening
  • Level 3: All other studies
Researchers: 

Please contact the Research and Innovation Support Office about the restart of your research. Before deciding to restart your research at the Trust, please ensure:

  • The continued viability of the research, including the impact of any amendments to the study protocol
  • Whether clinical services are available within the Trust to continue supporting the research
  • That all Trust infection control measures can be implemented to ensure the safety of participants and staff
Sponsors:

Please contact the Research and Innovation Support Office:

  • For information on our response whilst dealing with the COVID-19 outbreak
  • To discuss plans for restarting your research study within the Trust
  • To discuss the ongoing management of your study at ELHT
  • For advice relating to on-site monitoring visits during the pandemic
  • If you’d like any further information about our research

COVID-19

For further information about these studies please contact the Research Support Office by calling 01254 732756.

Short title

Description

Status

Local Researcher

 Sponsor

Find out more
ISARIC4C ISARIC/WHO Coronavirus Clinical Characterisation Protocol for Severe Emerging Infections Open Dr S Chukkambotla Oxford University Hospitals NHS Trust Study website
UKOSS Pandemic Influenza in Pregnancy  Open Ms S Loveridge University of Oxford Study website
RECOVERY  Randomised Evaluation of COVID-19 Therapy Open Dr S Chukkambotla University of Oxford Study website
REMAP-CAP Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) Open Dr S Chukkambotla University Medical Center Utrecht Study website
GENOMICC Genetics of Susceptibility and Mortality in
Critical Care
Study		 Open Dr M Smith University of Edinburgh and NHS Lothian Health Board Study website
COVER The impact of COVID-19 pandemic on the provision, practice and outcomes of vascular surgery Open Mr S Hardy University Hospitals Coventry and Warwickshire NHS Trust Study website
Pan-Covid Pregnancy And Neonatal outcomes for women with Covid-19 Open Mrs B Hammond Imperial College London Study website
ATOMIC2  A multi-centre open-label two-arm randomised superiority clinical trial of Azithromycin versus usual care In Ambulatory COVID-19 Open Dr R Garlapati University of Oxford Study website
PIMCO The psychological impact of surviving an intensive care admission due to coronavirus disease 2019 (COVID-19) on patients in the United Kingdom Open Dr N Truman Liverpool University Hospitals Study website

Last updated 23rd February 2021

Anaesthetics, pain and critical care

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

 Sponsor

Further information
ALLEGRO* A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery Prof A Krige University of Edinburgh and NHS Lothian ALLEGRO study website
CASAP* Children's Acute Surgical Abdomen Programme Dr I Clegg University College London  
EFFORT*  The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial Dr S Clarke Queen's University at Kingston  
MET-REPAIR* MET: REevaluation for Perioperative cArdIac Risk
(MET-REPAIR): a prospective, multi–centre cohort
observational study		 Dr S Chukkambotla  University of Leeds  
MET-REPAIR-FRAILTY* MET-REPAIR-FRAILTY: Frailty substudy of MET: REevaluation for Perioperative cArdIac Risk  Dr S Chukkambotla University of Leeds  

PQIP*

Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme

Dr M Pollard

 University College London

PQIP website
VITDALIZE* Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency
The UK arm of an International Multi-Centre, Placebo-Controlled, Phase III Double-Blind trial		 Dr Anton Krige  University of Birmingham University of Birmingham

 * Study restarted/open to recruitment

Last updated 16 March 2021

Cancer, including cancers of the blood

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of our cancer studies, please contact the cancer research team on 01254 733299.

Short title

Description

Local researcher

 Sponsor

Find out more
ACE* A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) Dr Parikh University Hospitals Bristol NHS Trust  
ACELARATE A Phase III, open label, multicentre randomised clinical study
comparing Acelarin (NUC-1031) with Gemcitabine in patient
with metastatic pancreatic carcinoma.
 		 Dr Ferreira The Clatterbridge Cancer Centre NHS Foundation Trust  
ATLANTIS* An adaptive multi-arm phase II trial of maintenance targeted therapy after
chemotherapy in metastatic urothelial cancer		 Dr Parikh NHS Greater Glasgow & Clyde and the University of Glasgow Cancer Research UK website
BC-Predict* Impact & acceptability of 10 year risk at breast cancer screening v1  Mr R Dobrashian Manchester University NHS Foundation Trust Cancer Research UK website
CLOCS*

Cancer Loyalty Card Study

This study is recruiting women with ovarian cancer and healthy female volunteers. For further details please visit the CLOCS study website

 Dr Badea Imperial College London CLOCS study webpage
MAGNITUDE* Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Subjects with Metastatic Prostate Cancer Dr O Parikh Janssen  
MOSES* Evaluation of the role of tongue base MucOsectomy and Step sErial Sectioning in the management of the unknown primary squamous cell cancer in the head and neck Miss N Ghazali The Royal Marsden NHS Foundation Trust Be Part of Research website
PATHOS* A Phase II/III trial of risk-stratified, reduced intensity adjuvant
treatment in patients undergoing transoral surgery for Human
papillomavirus (HPV)-positive oropharyngeal cancer		 Miss N Ghazali Velindre University NHS Trust & Cardiff University Cancer Research UK website
Prevalence* Biomarker Study to Determine Frequency of DNA-repair Defects in Men with Metastatic Prostate Cancer (Prevalence) Dr O Parikh Janssen  
PRIMETIME* Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers: Breast cancer Dr M Hogg Institute of Cancer Research Cancer Research UK website
PROTECTOR* Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal Mr M Willett  Queen Mary University of London PROTECTOR study webpage
Q-ABC* Quality of life After Bladder Cancer (Q-ABC): A comparison of patient related outcomes following radical surgery and radiotherapy Dr O Parikh Brighton and Sussex University Hospitals NHS Trust SHORE-C website

Rapper

Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy

Dr Charnley

 University of Manchester NHS choices

Stampede

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy

Dr O Parikh

 MRC Clinical Trials Unit at University College London

Cancer Research UK website

UKGPC study*

UK Genetic Prostate Cancer Study

Dr O Parikh

 The Institute of Cancer Research

The Institute of Cancer Research website

Cancer Research UK website
CPET & Whipples* Clinical effectiveness of CPET in predicting outcomes of Whipple Miss A Sultana East Lancashire Hospitals NHS Trust  

* Study restarted/open to recruitment

Last updated 24th March 2021

Child and adolescent mental health

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

Short title

Description

Local researcher

 Sponsor

Further information
  Early onset obsessive compulsive disorder Dr D Mahadevan University of Cambridge  

Diabetes, stroke, heart and blood vessel disease

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local Researcher

 Sponsor

Find out more
Address-2* An incident and high risk type 1 diabetes research cohort –
After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2)		 Diabetes Dr Del Rio Imperial College London ADDRESS-2 study website
CODIFI2* Randomised controlled trial of swab versus tissue sampling for infected diabetic foot ulcers, and comparison of culture versus molecular processing techniques Diabetes Ms J Lomax University of Leeds  
DROPLET* Defining The Rate Of Progression Of Late Onset Type 1 Diabetes Diabetes Dr S Ramtoola Royal Devon and Exeter NHS Foundation Trust  
In-Range* TOUJEO® and TRESIBA® in terms of glucose values in target range and variability during continuous glucose monitoring in patients with type 1 diabetes mellitus Diabetes Dr S Ramtoola Sanofi  

MYDIABETES*

 MODY in young-onset diabetes in different ethnicities

Diabetes

Dr S Ramtoola

 Imperial College of Science, Technology and Medicine

My DIABETES study webpage

BRAINS

British repository of DNA in stroke: towards the identification of new drug targets

Stroke

Dr N Goorah 

 Imperial College Healthcare NHS Trust

The BRAINS study website
CONVINCE COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke Stroke Dr A Singh University College Dublin  
PRISM* Purines for Rapid Identification of Stroke Mimics (PRISM): a diagnostic accuracy study Stroke C Curley Northumbria Healthcare NHS Foundation Trust  
R4VAD Rates, Risks and Routes to Reduce Vascular Dementia Stroke Sheeba Philip NHS Lothian  
Orion-4* A double-blind randomized placebo-controlled trial assessing
the effects of inclisiran on clinical outcomes among people with
atherosclerotic cardiovascular disease		 Heart and blood vessel Dr Ramtoola University of Oxford  
Developing a model of post stroke body image perceptions*   Stroke Samantha Hancock University of Central Lancashire  

* Study restarted/open to recruitment

Last updated 01st March 2021

Digestive tract and liver

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

 Sponsor

Find out more

IBD BioResource*

 The UK inflammatory bowel disease bioresource: Progressing from genetics to function and clinical translation in Crohn's Disease & Ulcerative Colitis

Crohn's disease

Dr J Collum

 Cambridge University Hospital NHS Foundation Trust

IBD BioResource webpage
STATIC STATIC – STopping Aminosalicylate Therapy in Inactive Crohn’s Disease (STATIC) Study: A Randomized, Open-label, Non-inferiority Trial Crohn's disease Dr J Collum Robarts Clinical Trials Inc. British Society of Gastroenterology website
Phase 2 dose-finding UC study A 54-Week Treatment, Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo and Active-Controlled, Parallel-Group Phase 2 Study to Assess the Efficacy and Safety of Brazikumab in Participants with Moderately to Severely Active Ulcerative Colitis Ulcerative Colitis Dr J Collum Allergan Limited  

* Study restarted/open to recruitment

Last updated 9th November 2020

Ear, nose and throat, infectious diseases, eyes and lungs

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

 Sponsor

Find out more
BICS A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease Lung Dr I Crossingham University of Aberdeen/NHS Grampian BICS study website

EMBARC: European Bronchiectasis Registry

The EMBARC European Bronchiectasis Registry

Lung

Dr I Crossingham

 NHS Tayside

EMBARC website
POPT* Assessing Post-Operative bleeding, pain and return to work following Tonsillectomy ENT Mr Elliot Heward Wrightington, Wigan and Leigh NHS Foundation Trust   
GTScope* GTSCOPE - A study of disease progression in patients with Dry-AMD Eye Ms Salwa Abugreen Gyroscope Therapeutics Ltd

Gyroscope website

Study poster

Last updated 06 April 2021

Skin, muscle, bone and connective tissue disorders

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

 Sponsor

Find out more

Dupuytren’s Interventions Surgery vs. Collagenase (DISC)*

A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients

Musculoskeletal

Dr F Younis

 University Hospitals of Leicester NHS Trust

UK Clinical Trials Gateway

PREVENT-RA

PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis

Musculoskeletal

Prof L Teh

 University of Manchester

PREVeNT RA website

TOXICITY FROM BIOLOGIC THERAPY (BSRBR)*

Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis

Musculoskeletal

Prof L Teh

 University of Leeds

University of Manchester BSRBR-RA study website
UKIVAS  Development of a Pan UK Vasculitis Cohort to Analyse Variations in Disease Susceptibility and Outcomes Musculoskeletal Prof L Teh University of Oxford  

BADBIR*

British Association of  Dermatologists Biologic Interventions Register

Skin

Dr Owen

 University of Manchester

BADBIR study website

B-STOP*

A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis

Skin

Dr Owen

 Guy's and St Thomas' NHS Foundation Trust

 

Last updated 9th November 2020

Surgery, injuries and emergencies

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

 Sponsor

Find out more
ARTISAN  Acute Rehabilitation following Traumatic anterior shoulder dISlocAtioN (ARTISAN) - A Multi Centre RCT Mr S Hadi/Rachel Dean University of Warwick and University Hospitals Coventry & Warwickshire NHS Trust ARTISAN study webpage
CIPHER* UK cohort study to investigate the prevention of parastomal hernia Mr L Jones Royal Devon & Exeter NHS Foundation Trust  
MURALS Study* Comparing the musculoskeletal demands of surgeons performing Robotic-assisted Laparoscopic surgery and standard laparoscopic surgery Mr D Subar Lancaster University  
Panraman New biomarker identification of pancreatic cancer to improve diagnosis Mr D Subar Lancaster University  
The Sunflower Study* A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones Mr D Subar Leeds Teaching Hospitals NHS Trust CTEU Bristol website
SUNRISE* Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy
Surgery		 Mr L Jones University of Birmingham Birmingham Clinical Trials Unit website
The use of Locum Doctors in the NHS* The use of locum doctors in the NHS: understanding and improving the safety and quality of care Suzanne Gawne University of Manchester University of Manchester
Recurrance after Whipple's (RAW)* An international multi-centre retrospective cohort study investigating factors affecting cancer recurrence following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, ampullary adenocarcinoma and distal bile duct cholangiocarcinoma Miss A Kausar University of Southampton NHS Trust National Institute for Health Research
FAMOUS C19*
The impact of COVID-19 pandemic on the assessment, management and outcomes for patients with common ...
Mr S Hadi
South Tees Hospitals NHS Trust
 

* Study restarted/open to recruitment

Last updated 16 March 2021

Women, newborn and children’s research

You may need to talk to your doctor or midwife about taking part in the studies listed here.

If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact the women's health research team:

Burnley General Hospital: 01282 803081

Royal Blackburn Hospital: Women's health: 01254 732650; Children's research: 01254 732643.

Short title

Description

Patient group

Local Researcher

 Sponsor

Find out more

BIOJUME*

Biology of Juvenile Myoclonic Epilepsy 

Children

Dr R Belderbos

 Kings College London

Childhood Epilepsy website
CASAP* Children's Acute Surgical Abdomen Programme Children Dr I Clegg University College London  
CF Start*

The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial

 Children Dr D Corbett Alder Hey Childrens NHS FT CF START website

RaDaR

National Studies of Rare Kidney Diseases

Children

Dr J Iqbal

 Medical Research Council

Rare Renal website
REGAIN* Rolandic Epilepsy Genomewide Association International Study
(REGAIN)		 Children Dr R Belderbos King’s College London and King’s College Hospital NHS Trust Childhood Epilepsy.org website
USTEKID* Ustekinumab in adolescents with recent-onset type 1 diabetes Children Dr Gardner Cardiff University  

UK ITP registry*

The UK Paediatric ITP Registry

Children,

Dr V Holme

 Royal Manchester Children's Hospital

UK Paediatric ITP Working Party website
Address-2* An incident and high risk type 1 diabetes research cohort –
After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2)		 Children, diabetes Dr Del Rio Imperial College London ADDRESS-2 website
OPTI-SURF* Optimal surfactant delivery for preterm babies with
respiratory distress syndrome.The effect of surfactant dose on
outcomes in preterm infants with Respiratory Distress
Syndrome		 Neonatal Dr A Sur Chiesi Limited  
Big baby trial* Induction of labour for predicted macrosomia ‘The Big Baby Trial’ Reproduction Dr S Davies University Hospitals Coventry and Warwickshire NHS Trust UK Clinical Trials Gateway
CERM* Chronic Endometritis and Recurrent Miscarriage - The CERM trial Reproduction F Clarke University Hospitals Coventry and Warwickshire NHS Trust Warwick Clinical Trials Unit website
CRAFT* Cerclage after full dilatation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies Reproduction F Clarke King's College London  
C-Stich2* Cervical Cerclage to Prevent Miscarriage and Preterm Birth - a Randomised Controlled Trial Reproduction Mr Yen Eit Liew Birmingham Women's and Children's NHS Foundation Trust Birmingham Clinical Trials Unit
FROSTTIE* A randomised controlled trial of FRenotomy and breastfeeding support Or breastfeeding Support without frenotomy to investigate continuation of breastfeeding for babies with Tongue-TIE Reproduction B Hammond University of Oxford  FROSTTIE study webpage

GEM3*

A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy

Reproduction

Ms F Clarke

 NHS Lothian

Birmingham Clinical Trials Unit
LOCI* Letrozole Or Clomifene for Ovulation Induction Reproduction Ms Nethra University of Birmingham  
NAPES* Neurodevelopment after prenatal exposure to seizures (NAPES) Study Reproduction   The University of Manchester  
Born into care Born into care: towards inclusive guidlines when the state intervenes at birth Neonatel Catherine Walton Lancaster University  
The Parrot-2 Trial* Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia Reproduction Mr Maher King's College London Parrot-2 website

* Study restarted/open to recruitment

Last updated 25th March 2021

Finding research studies on the internet

Clinical research studies happening locally and nationally can be found by searching the following databases: