Information for patients taking part in research

We're so grateful to all the East Lancashire patients who’ve volunteered to take part in health research. You join over 20,000 participants from our hospitals, who contribute to a better understanding of disease and finding new treatments.

Safety is our priority

The safety of patients and hospital staff is our top priority and we are following the Trust guidance for infection control and hospital appointments. This includes minimising footfall on the hospital site, maintaining social distancing and using decontamination procedures.

If you’re taking part in a research study

If you were taking part in a research study at the hospital before the COVID-19 outbreak, the study team will have contacted you to discuss any changes to your follow up appointments, or to your medication and how to collect this from the hospital. As we restart any research that was temporarily paused, the study team will continue to inform you of any changes that may affect you.

If you have any questions or concerns, please don’t hesitate to get in touch with your study team. Their contact details are as follows:

For women’s health research: 01282 803081
For children's research: 01254 732643
For cancer research: 01254 733299
For all other research: 01254 732756

To find out more about our research 

If you’d like to find out more about research at East Lancashire Hospitals, please visit the research pages of this website or you can also follow us on twitter @ELHTresearch. The Be Part of Research website also provides more information on research and lists the studies taking place in East Lancashire and nationally throughout the NHS.

You can find out more about our response to the COVID-19 pandemic here.

COVID-19

For further information about these studies please contact the Research Support Office by calling 01254 732756.

Short title

Description

Status

Local Researcher

Sponsor

Find out more

ISARIC ISARIC/WHO Coronavirus Clinical Characterisation Protocol for Severe Emerging Infections Open Dr S Chukkambotla Oxford University Hospitals NHS Trust Study website
RECOVERY  Randomised Evaluation of COVID-19 Therapy Open Dr Nick Truman University of Oxford Study website
REMAP-CAP Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) Open Dr Nick Truman University Medical Center Utrecht Study website
GENOMICC Genetics of Susceptibility and Mortality in
Critical Care
Study
Open Dr M Smith University of Edinburgh and NHS Lothian Health Board Study website

* Study not open to new participants at ELHT (Temporary pause due to COVID 19)

Last updated 07th October 2022

Anaesthetics, pain and critical care

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Further information

ALLEGRO A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery Prof A Krige University of Edinburgh and NHS Lothian ALLEGRO study website

PQIP

Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme

Dr M Pollard

University College London

PQIP website

VITDALIZE Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency
The UK arm of an International Multi-Centre, Placebo-Controlled, Phase III Double-Blind trial
Dr Anton Krige  University of Birmingham University of Birmingham
MOSAICC  Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administered for critically ill patients with acute kidney injury and metabolic acidosis Dr Matthew  Smith University Hospitals of  Derby and Burton NHS Foundation Triust  
SQUEEZE

A prospective multi-centre international observational study of postoperative vasopressor use

Dr David Freeman European Society of Anaesthesiology https://www.esaic.org/research/clinical-trial-network/squeeze/
IREHAB Remote Rehab after ICU Dr Nick Truman Ulster University https://warwick.ac.uk/fac/sci/med/research/ctu/trials/irehab/

* Study not open to new participants at ELHT (Temporary pause)

Last updated 25th January 2023 

Digestive tract and liver

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

IBD BioResource

The UK inflammatory bowel disease bioresource: Progressing from genetics to function and clinical translation in Crohn's Disease & Ulcerative Colitis

Crohn's disease

Dr J Collum

Cambridge University Hospital NHS Foundation Trust

IBD BioResource webpage

* Study not open to new participants at ELHT (Temporary pause)

Last updated 01st November 2022

Cancer, including cancers of the blood

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of our cancer studies, please contact the cancer research team on 01254 733299.

Short title

Description

Local researcher

Sponsor

Find out more

CLOCS*

Cancer Loyalty Card Study

This study is recruiting women with ovarian cancer and healthy female volunteers. For further details please visit the CLOCS study website

Dr Badea Imperial College London CLOCS study webpage
PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant
treatment in patients undergoing transoral surgery for Human
papillomavirus (HPV)-positive oropharyngeal cancer
Mr K Panayiotis Velindre University NHS Trust & Cardiff University Cancer Research UK website
PROTECTOR Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal Mr M Willett  Queen Mary University of London PROTECTOR study webpage

Rapper*

Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy

Dr Charnley

University of Manchester NHS choices

Stampede*

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy

Dr O Parikh

MRC Clinical Trials Unit at University College London

Cancer Research UK website

UKGPC study

UK Genetic Prostate Cancer Study

Dr O Parikh

The Institute of Cancer Research

The Institute of Cancer Research website

Cancer Research UK website

POETIC-A PreOperative Endocrine Therapy for Individualised Care with Abemaciclib Miss C Yip The Institute of Cancer Research The Institute of Cancer Research website
ICI Genetics Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity Dr Hassan Shikhrakab University of Birmingham If you wish to take part in the study or know more about what it involves, please contact our research team using our email address ici-genetics@contacts.bham.ac.uk
TINIVO 2 A Phase 3, Randomized, Controlled, Multicenter, Open-label Study to Compare Tivozanib in Combination with Nivolumab to Tivozanib Monotherapy in Subjects with Renal Cell Carcinoma Who Have Progressed Following One or Two Lines of Therapy Where One Line has an Immune Checkpoint Inhibitor Dr Omi Parikh Aveo Pharmaceuticals Aveo Pharmaceuticals_TINIVO 2
Contact-02 A Phase 3, Randomized, Open-Label, Controlled Study of Cabozantinib (XL184) in Combination with Atezolizumab vs Second Novel Hormonal Therapy (NHT) in Subjects with High-Risk, Metastatic Castration-Resistant Prostate Cancer Dr Omi Parikh Exelixis Inc Exelixis website
PanCanCGM Continuous glucose monitoring in patients with pancreatic cancer Mr D Subar Lancaster University  
DETECT-ASCEND 2 Detecting cancers Earlier Through Elective plasma-based CancerSEEK Testing Ascertaining Serial Cancer patients to Enable New Diagnostic II Dr Ana Ferreira Exact Sciences Corp.  
ATNEC
ATNEC–Axillary management in T1‐3N1M0 breast cancer patients with FNA or core biopsy proven nodal metastases at presentation who convert to node negative after NEoadjuvant Chemotherapy
Mr Inder Kumar University Hospitals of Derby and Burton NHS FT                 ATNEC

 

* Study not open to new participants at ELHT (Temporary pause)

Last updated 04th January 2023

Child and adolescent mental health

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

Short title

Description

Local researcher

Sponsor

Further information

Glycopy Bromide A study to assess utilisation and safety of Glycopyrronium Bromide 1mg/5ml Oral Solution as licensed for symptomatic treatment of severe sialorrhoea in children and adolescents aged 3 years and older with chronic neurological disorders in the UK Dr Vanessa Holme DSRU Education and Research Limited  
CRAFFT Children’s Radius - Acute Fracture Fixation Trial: A multi-centre prospective randomised non-inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children Dr Fizan Younis University of Oxford https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/crafft

* Study not open to new participants at ELHT (Temporary pause)

 Last updated: 11th January 2022

Diabetes, stroke, heart and blood vessel disease

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local Researcher

Sponsor

Find out more

Address-2 An incident and high risk type 1 diabetes research cohort –
After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2)
Diabetes Dr Del Rio Imperial College London ADDRESS-2 study website

BRAINS

British repository of DNA in stroke: towards the identification of new drug targets

Stroke

Dr N Goorah 

Imperial College Healthcare NHS Trust

The BRAINS study website

CONVINCE COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke Stroke Dr A Singh University College Dublin https://www.uclan.ac.uk/research/activity/convince
Orion-4 A double-blind randomized placebo-controlled trial assessing
the effects of inclisiran on clinical outcomes among people with
atherosclerotic cardiovascular disease
Heart and blood vessel Dr Ramtoola University of Oxford https://www.ctsu.ox.ac.uk/research/orion-4
RECREATE A multicentre cluster randomised controlled trial evaluating the clinical and cost-effectiveness of an intervention to reduce sedentary behaviour in stroke survivors incorporating an internal pilot phase and embedded process evaluation Stroke Samantha Hancock Bradford Teaching Hospitals NHS Foundation Trust Bradford Teaching Hosptals NHS Foundation Trust website
L-HARP Liverpool Heart and Brain Project Stroke Sheeba Philip University of Liverpool https://www.lhch.nhs.uk/research/clinical-trials-unit/contributing-to-clinical-research/

EVAREST

The use of Blood Biomarkers, including extracellular vesicles to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram Cardiovascular Sanjay Banypersad University of Oxford https://www.rdm.ox.ac.uk/about/our-clinical-facilities-and-mrc-units/cardiovascular-clinical-research-facility/evarest-1/about-evarest
iCorMicA International study of Coronary Microvascular Angina (iCorMicA): a randomised, controlled, multicentre trial and registry Cardiovascular Dr Balachandran NHS Greater Glasgow and Clyde Healthboard Clinical Trials.gov website
OPTIMAS OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial.  Stroke  Dr Singh  University College London  https://optimas.org.uk/
AFAR Atrial Fibrillation  After Resection  Cardiovascular Mr Heywood Sheffield Teaching Hospital AFAR
DNA Lacunar  Genetic risk factors for cerebral small vessal disease Stroke Dr Anand Nair Cambridge University Hospitals University of Cambridge

* Study not open to new participants at ELHT (Temporary pause)

Last updated 27th September 2022

Ear, nose and throat, infectious diseases, eyes and lungs

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

SAVER Sodium Valproate for Epigenetic Reprogramming in the Management of High Risk Oral Epithelial Dysplasia Oral and Dental Health Mr K Panayiotis University of Liverpool https://livrepository.liverpool.ac.uk/3130119/
PHIND Clinical evaluation of a POC assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome Respiratory Dr Waqar-Uddin Queen's University Belfast  
UNICORNS UNICORNS: Uveitis in childhood Opthalmology Mrs M Mohan UCL Great Ormond Street Intitute of Child Health (ICH)  

* Study not open to new participants at ELHT (Temporary pause)

Last updated 19th October 2022

Skin, muscle, bone and connective tissue disorders

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

         

 

BADBIR

British Association of  Dermatologists Biologic Interventions Register

Skin

Dr Owen

University of Manchester

BADBIR study website

B-STOP

A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis

Skin

Dr Owen

Guy's and St Thomas' NHS Foundation Trust

 

BILAG BILAG Biologic Prospective Cohort Musculoskeletal Prof L S Teh University of Manchester  
Toxicity from biological therapy (BSRBR) Prospective observational study of the long term hazards of biologic therapy in rheumatoid arthritis. Musculoskeletal Prof Symmons Universuty of Manchester https://www.bsrbr.org/
IMID Bioresource IMID (Immune-Mediated Inflammatory Diseases)BioResource - part of NIHR BioResource Muskoskeletal Prof L S Teh University of Manchester  
Hand 2 Hand-2: Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers: a randomised, multi-centre non-inferiority trial Rheumatology Mr Fizan Younis Nottingham University Hospitals NHS Trust The Hand 2 Study
Regeneten REGENETEN™ Bioinductive Implant System in Full-thickness Tears Muskoskeletal Mr S Hadi Smith and Nephew Limited Smith and Nephew: Regeneten

* Study not open to new participants at ELHT (Temporary pause)

Last updated 30th January 2023

Surgery, injuries and emergencies

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Find out more

Panraman New biomarker identification of pancreatic cancer to improve diagnosis Mr D Subar Lancaster University  
The Sunflower Study A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones Mr D Subar Leeds Teaching Hospitals NHS Trust CTEU Bristol website
UK-ROX Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. Dr N Truman Intensive Care National Audit & Research Centre ICNARC website
SPECS A mechanistic trial comparing standard care versus prehabilitation in patients undergoing elective HPB and colorectal cancer surgery: a feasibility study Dr Joel Lambert East Lancashire Hospitals NHS Trust  
The Point Trial POINT - A multi-centre randomised trial of surgery versus non-surgical splint treatment for proximal phalanx shaft finger fractures in adults. Mr Fizan Younis University of Nottingham https://njl-admin.nihr.ac.uk/document/download/2037591
The Orion Trial Radio Frequency ablation for haemorrhoids (ORION) Mr Louis Vitone Sheffield Teaching Hospitals NHS FT The Orion Trial

* Study not open to new participants at ELHT (Temporary pause)

Last updated 6th December 2022

Women, newborn and children’s research

You may need to talk to your doctor or midwife about taking part in the studies listed here.

If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact the women's health research team:

Burnley General Hospital: 01282 803081

Royal Blackburn Hospital: Women's health: 01254 732650; Children's research: 01254 732643.

Short title

Description

Patient group

Local Researcher

Sponsor

Find out more

 
CF Start

The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial

Children Dr D Corbett Alder Hey Childrens NHS FT CF START website  
REGAIN Rolandic Epilepsy Genomewide Association International Study
(REGAIN)
Children Dr R Belderbos King’s College London and King’s College Hospital NHS Trust Childhood Epilepsy.org website  

UK ITP registry

The UK Paediatric ITP Registry

Children,

Dr V Holme

Royal Manchester Children's Hospital

UK Paediatric ITP Working Party website

 
Address-2 An incident and high risk type 1 diabetes research cohort –
After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2)
Children, diabetes Dr Del Rio Imperial College London ADDRESS-2 website  
CRAFT Cerclage after full dilatation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies Reproduction F Clarke King's College London    
LOCI Letrozole Or Clomifene for Ovulation Induction Reproduction Ms Nethra University of Birmingham    
Tommys Rainbow The Tommy's National Rainbow Clinic Study Children Mr Maher The University of Manchester https://www.tommys.org/  

ESPRIT 2

 

 

 

A multi-centre randomised controlled trial to determine the effectiveness of laparoscopic removal of isolated
superficial peritoneal endometriosis for the management of chronic pelvic pain in women: ESPriT2
Reproduction Dr Wittersheim The University of Edinburgh https://www.ed.ac.uk/centre-reproductive-health/exppect-endometriosis/research/esprit  
Giant Panda Pregnancy ANtihypertensive Drugs: which Agent is best? Reproduction Dr Davies University of Birmingham https://www.birmingham.ac.uk/research/bctu/trials/womens/giantpanda/index.aspx  
FACT4CHILD Folic Acid Clinical Trial: Follow up of children

Children

Heather Collier Ottawa Hospital, Canada https://clinicaltrials.gov/ct2/show/NCT03269110  
REGAL Study Recurrence of Endometriosis: A randomised controlled trial of clinical and cost-effectiveness of Gonadotrophin Releasing Hormone Analogues with add-back hormone replacement therapy versus repeat Laparoscopic surgery(REGAL trial) Reproduction Mr Aty University of Aberdeen University of Aberdeen  
GBS3
The clinical and cost-effectiveness of testing for Group B Streptococcus: a cluster randomised trial with economic and acceptability evaluations (GBS3)
Reproduction Dr Justine Nugent University of Nottingham https://www.gbs3trial.ac.uk/home.aspx  
iGBS3 Development of a serocorrelate of protection against invasive Group B Streptococcus disease (iGBS) Children Dr Konstantindis St Georges University of London https://www.gbsatstgeorges.co.uk/igbs3  
COPE The Carboprost or Oxytocin Postpartum haemorrhage Effectiveness Study Reproduction Mr Yen Eit Liew University of Liverpool https://copestudy.uk/  
ABA-Feed The effectiveness and cost-effectiveness of Assets-based feeding help Before and After birth. Reproduction Bev Hammond University of Birmingham

https://aba-feed.org/

 

 
HARMONIE A Phase IIIb randomized open label study of nirsevimab (versus no intervention) in preventing hospitalizations due to respiratory syncytial virus in infants Children Dr Konstantindis
Sanofi Harmonie Trial Information  
FERN Intervention or expectant management of early onset selective fetal growth restriction in Monochorionic Twim Pregnancy Reproduction Mr Martin Maher University of Liverpool The Fern Study UoL  
STOPPIT-3 A Randomised Placebo-Controlled Trial of Antenatal Corticosteroids for Planned Birth in Twins Reproduction Dr Justine Nugent Edinburgh Clinical Trials Unit The University of Edinburgh  
NEOAMRO Neonatal Antimicrobial Resistance and Outcomes Children Dr Jayanthi Murali St Georges University of London NeoAMRO  
POISE
Hormone therapy for premature ovarian insufficiency: randomised trial and long-term evaluation
Reproduction Ms Nethra University College London https://poise.ac.uk/home.aspx  

* Study not open to new participants at ELHT (Temporary pause)

Last updated 31st January 2023

Finding research studies on the internet

Clinical research studies happening locally and nationally can be found by searching the following databases: