Current Studies :: East Lancashire Hospitals NHS Trust

Anaesthetics and pain

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Local researcher	Sponsor	Further information
ALLEGRO	A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery	Prof A Krige	University of Edinburgh and NHS Lothian	ALLEGRO study website
ASCRIBED	The impact of Acute Systematic inflammation upon cerebrospinal fluid and blood Biomarkers of brain inflammation and injury in Dementia: a study in acute hip fracture patients	Dr A Shannon	University of East Anglia
PQIP	Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme	Dr M Pollard	University College London	PQIP website

Last updated 18th December 2018

Cancer, including cancers of the blood

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of our cancer studies, please contact the cancer research team on 01254 733299.

Short title	Description	Local researcher	Sponsor	Find out more
ACE	A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ)	Dr Parikh	University Hospitals Bristol NHS Trust
CIPHER	UK cohort study to investigate the prevention of parastomal hernia	Mr L Jones	Royal Devon & Exeter NHS Foundation Trust	UK Clinical Trials Gateway
HORIZONS	HORIZONS: Understanding the impact of cancer diagnosis and treatment on everyday life (breast, gynaecological cancer and non Hodgkin lymphoma)	K Jewers	University Hospital Southampton NHS Foundation Trust	Horizons study website
IPATential 150 prostate study	A phase III, randomised, double-blind, placebo controlled multi-centre trial testing Ipatasertib plus Abiraterone plus Prednisone/Prednisolone relative to placebo plus abiraterone plus prednisone/prednisolone in adult male patients with asymptomatic or mildly symptomatic, previously untreated, metastatic castrate-resistant prostate cancer	Dr O Parikh	Hoffman - La Roche Ltd
Measures	The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative Neoplasms	Dr Adiyodi	Guy's and St Thomas' NHS Foundation Trust
NSCCG	National Study of Colorectal Cancer Genetics	Dr M Wise	Institute of Cancer Research	Cancer Research UK website
qFit	A new test for ruling out colorectal cancer - The qFIT Pilot	Dr J Collum	University College London	University College Hospital website
RAIDER	A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder	Dr O Parikh	Institute of Cancer Research	Cancer Research UK website
Rapper	Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy	Dr Charnley	University of Manchester	NHS choices
SEARCH	A population based study of genetic predispositions and gene-environment interactions in cancer (ovarian and endometrial)	Dr M Hogg	Cancer Research UK	Cancer Research UK website
Stampede	Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy	Dr O Parikh	Medical Research Council	Cancer Research UK website
True NTH UK (post surgery follow-up)	Development and evaluation of a patient-reported instrument to monitor oncological and functional outcomes after radical prostatectomy (prostate)	Mr S Srirangham	University College London	UK Clinical Trials Gateway
UKGPC study	UK Genetic Prostate Cancer Study	Dr O Parikh	The Institute of Cancer Research	The Institute of Cancer Research website Cancer Research UK website

Last updated 18th December 2018

Critical care

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Local researcher	Sponsor	Further information
PQIP	Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme	Dr M Pollard	University College London	PQIP website
The “65” Trial	Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension	Dr J Roberts	Intensive Care National Audit and Research Centre (ICNARC)	UK Clinical Trials Gateway
The REST study	Protective ventilation with veno-venous lung assist in respiratory failure	Dr S Chukkambotla	Belfast Health & Social Care Trust

Last updated 11th February 2019

Diabetes, stroke, heart and blood vessel disease

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Patient group	Local Researcher	Sponsor	Find out more
MYDIABETES	A cross-sectional study to characterise young onset diabetes in two UK ethnic groups	Diabetes	Dr S Ramtoola	Imperial College of Science, Technology and Medicine	My DIABETES study webpage
StartRight	Getting the right classification and treatment from diagnosis of diabetes	Diabetes	Dr S Ramtoola	Royal Devon and Exeter NHS Foundation Trust
ATAM - Developing and validating a therapeutic alliance measure	Aphasia Therapeutic Alliance Measure (ATAM): Development and preliminary psychometric evaluation	Stroke	Catherine Curley	University of Manchester
BRAINS	British repository of DNA in stroke: towards the identification of new drug targets	Stroke	Dr N Goorah	Imperial College Healthcare NHS Trust	The BRAINS study website
CONVINCE	COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke	Stroke	Dr A Singh	University College Dublin
LLIFT	Pilot study to test the clinical efficacy of FlowOx™ home treatment compared to standard care in patients with critical limb ischemia and lower limb ulcers	Blood vessels	Mr Simon Hardy	University of Salford
EVAREST	The use of blood biomarkers, including extracellular vesicles, to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram	Heart	Dr Sanjay Banypersad	University of Oxford	The EVAREST study webpage
MASTER DAPT	MAnagement of high bleeding risk patients post bioresorbable polymer coated STEnt implantation with an abbReviated versus prolonged DAPT regimen	Heart	Dr J McDonald	European Cardiovascular Research Institute (ECRI)	ECRI study webpage
SFLEX2	Prospective Evaluation of Thin-Strut Biodegradable Polymer-coated Supraflex Sirolimus-Eluting Stents in an All-comers Patient Population (S-FLEX UK-II)	Heart	Prof S Garg	Sahajanand Medical Technologies Pvt. Ltd
UK GRIS	Effectiveness of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome	Heart	Prof S Garg	University of Leeds	UK Clinical Trials Gateway website

Last updated 11th February 2019

Ear, nose and throat, infectious diseases, eyes and lungs

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Patient group	Local researcher	Sponsor
Characterisation of subretinal hyper-reflective material in nAMD	The characterisation of subretinal hyper-reflective material using Heidelberg Optical Coherence Tomography and Heidelberg Multicolour imaging in neovascular age-related macular degeneration	Eyes	Dr Z Al-Moasseb	East Lancashire Hospitals NHS Trust
Stereotactic radiotherapy for wet AMD (STAR)	StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): A randomised, double-masked, sham-controlled, clinical trial comparing low-voltage X-ray irradiation with as needed ranibizumab, to as needed ranibizumab monotherapy	Eyes	Mrs S Abugreen	Kings College London
EMBARC: European Bronchiectasis Registry	The EMBARC European Bronchiectasis Registry	Lung	Dr I Crossingham	NHS Tayside

Last checked 18th December 2018

Skin, muscle, bone and connective tissue disorders

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Patient group	Local researcher	Sponsor	Find out more
BILAG-2004 VALIDATION	Validation of BILAG2004 index for assessment of disease activity in systemic lupus erythematosus	Musculoskeletal	Prof L Teh
Dupuytren’s Interventions Surgery vs. Collagenase (DISC)	A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients	Musculoskeletal	Dr F Younis	University Hospitals of Leicester NHS Trust	UK Clinical Trials Gateway
GRASP	GRASP: Getting it Right: Addressing Shoulder Pain. Clinical and cost effectiveness of progressive exercise compared to best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: a 2x2 factorial randomised controlled trial	Musculoskeletal	Dr A Hallett, Helen Thompson	University of Oxford	GRASP study website
PREVENT-RA	PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis	Musculoskeletal	Prof L Teh	University of Manchester	PREVeNT RA website
TOXICITY FROM BIOLOGIC THERAPY (BSRBR)	Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis	Musculoskeletal	Prof L Teh	University of Leeds	University of Manchester BSRBR-RA study website
USEFUL	UltraSound Evaluation For mUsculoskeletal Lupus	Musculoskeletal	Prof L Teh	University of Leeds
BADBIR	British Association of Dermatologists Biologic Interventions Register	Skin	Dr Owen	University of Manchester	BADBIR study website
B-STOP	A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis	Skin	Dr Owen	Guy's and St Thomas' NHS Foundation Trust

Last updated 11th February 2019

Surgery

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Local researcher	Sponsor	Find out more
DRAFFT 2	DRAFFT 2: Distal Radius Acute Fracture Fixation Trial - A Randomised Controlled Trial of Manipulation and surgical fixation with K-wires versus Manipulation and Casting in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius	Mr M Srinivasan	University of Oxford	University of Oxford website
HIP study	Hartmann’s procedure versus Intersphincteric APE	Mr A Sheikh	Countess of Chester Hospital NHS Foundation Trust
PPAC2 - Packing of Perianal Abscess Cavities 2	The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial	Miss J Smith	Manchester University NHS Foundation Trust	North West Research Collaborative website
PUrE	The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT Percutaneous nephrolithotomy (PNL), flexible Ureterorenoscopy (FURS) and Extracorporeal lithotripsy (ESWL) for lower pole kidney stones	Mr S Srirangam	University of Aberdeen	PUrE study website

Last updated 18th December 2018

Urology

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Local researcher	Sponsor	Find out more

Last updated 18th December 2018

Women, newborn and children’s research

You may need to talk to your doctor or midwife about taking part in the studies listed here.

If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact the women's health research team:

Burnley General Hospital: 01282 803081

Royal Blackburn Hospital: 01254 732650

Short title	Description	Patient group	Local Researcher	Sponsor	Find out more
BIOJUME	Biology of Juvenile Myoclonic Epilepsy	Children	Dr R Belderbos	Kings College London	Childhood Epilepsy website
CF Start	The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial	Children	Dr D Corbett	Alder Hey Childrens NHS FT	CF START website
EU Patch	EU Patch: The role of glasses wearing in amblyopia treatment	Children	Mrs M Mohan	University of Leicester	UK Clinical Trials Gateway
Prednos 2	Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study.	Children	Dr J Iqbal	University of Birmingham	Prednos 2 study website
RaDaR	National Studies of Rare Kidney Diseases	Children	Dr J Iqbal	Medical Research Council	Rare Renal website
REGAIN	Rolandic Epilepsy Genomewide Association International Study (REGAIN)	Children	Dr R Belderbos	King’s College London and King’s College Hospital NHS Trust	Childhood Epilepsy.org website
UK ITP registry	The UK Paediatric ITP Registry	Children,	Dr V Holme	Royal Manchester Children's Hospital	UK Paediatric ITP Working Party website
TrialNet LIFT Study	Long Term investigative Follow-up in TrialNet (LIFT)	Children, diabetes	Dr Ramtoola	University of Bristol	Trialnet study website
Trialnet (pathway to prevention study)	Natural history study of the development of type I diabetes, phase 1, 2 and 3	Children, diabetes	Dr C Gardner	University of Bristol	Trialnet study website
BabyOSCAR	Outcome after Selective early treatment for Closure of patent ductus ARteriosus in pre-term babies	Neonatal	Dr N Soni	University of Oxford	National Perinatal Epidemiology Unit website
OPTISURF	The effect of surfactant dose on outcomes in preterm infants with Respiratory Distress Syndrome	Neonatal	Dr D Kumar	Chiesi UK Limited	The Leeds Teaching Hospitals NHS Trust website
	Better care pathways in pregnancies after stillbirth	Reproduction	Cathie Melvin	The University of Manchester	UK Clinical Trials Gateway
Big baby trial	Induction of labour for predicted macrosomia ‘The Big Baby Trial’	Reproduction	Dr S Davies	University Hospitals Coventry and Warwickshire NHS Trust	UK Clinical Trials Gateway
C-STICH	The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH)	Reproduction	Mrs E Martindale	Birmingham Women's NHS Foundation Trust	Birmingham Clinical Trials Unit Website
GAPP2	A multi-centre randomised controlled trial of the efficacy and mechanism of action of gabapentin for the management of chronic pelvic pain in women	Reproduction	Mrs K Bhatia	University of Edinburgh	Birmingham Clinical Trials Unit website
GEM3	A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy	Reproduction	Dr F Clarke	NHS Lothian	Birmingham Clinical Trials Unit
MifeMiso	A randomised, placebo-controlled trial of mifepristone and misoprostol versus misoprostol alone in the medical management of missed miscarriage	Reproduction	Mrs K Bhatia	University of Birmingham	Birmingham Clinical Trials Unit website
NAPES	Neurodevelopment after prenatal exposure to seizures (NAPES) Study	Reproduction	Mrs Schram	The University of Manchester
PIP	Pipelle for pregnancy (PIP) studies	Reproduction	Mrs S Nethra	Auckland District Health Board (New Zealand)
PREP	Helping Pregnant smokers to quit: A multi-centre RCT of electronic cigarettes vs. nicotine patches (usual care)	Reproduction	Mr M Maher	Queen Mary University of London
STOPPIT 2	An open randomised trial of the Arabin pessary to prevent preterm birth in twin pregnancy, with health economics and acceptability	Reproduction	Dr J Nugent	University of Edinburgh	STOPPIT 2 trial website
UCON	Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action	ReproductionReproduction	Mrs K Bhatia	University of Edinburgh and NHS Lothian	Birmingham Clinical Trials Unit