The clinical research studies currently available to patients at East Lancashire Hospitals NHS Trust are listed below:
Anaesthetics and pain
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
|
ASCRIBED |
The impact of Acute Systematic inflammation upon cerebrospinal fluid and blood Biomarkers of brain inflammation and injury in Dementia: a study in acute hip fracture patients |
Dr A Shannon |
University of East Anglia |
|
|
Improving Tracheostomy Care |
Improving Tracheostomy Care - National Quality Improvement Programme |
Dr M Atkinson |
University Hospital of South Manchester NHS Foundation Trust |
|
|
PQIP |
Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme |
Dr M Pollard |
University College London |
Last checked 7th September 2018
Cancer, including cancers of the blood
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of our cancer studies, please contact the cancer research team on 01254 733299.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
| ACE | A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) | Dr Parikh | University Hospitals Bristol NHS Trust | |
|
Breast Tomosynthesis |
Accuracy of Fuji Amulet DBT views versus standard mammographic views for the diagnosis of soft tissue breast lesions (excluding microcalcification) |
Dr S Ahmad |
East Lancashire Hospitals NHS Trust |
|
| CIPHER | UK cohort study to investigate the prevention of parastomal hernia | Mr L Jones | Royal Devon & Exeter NHS Foundation Trust | UK Clinical Trials Gateway |
|
HORIZONS |
HORIZONS: Understanding the impact of cancer diagnosis and treatment on everyday life (breast, gynaecological cancer and non Hodgkin lymphoma) |
K Jewers |
University Hospital Southampton NHS Foundation Trust | |
|
IPATential 150 prostate study |
A phase III, randomised, double-blind, placebo controlled multi-centre trial testing Ipatasertib plus Abiraterone plus Prednisone/Prednisolone |
Dr O Parikh |
Hoffman - La Roche Ltd |
|
|
Measures |
The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative Neoplasms |
Dr Adiyodi |
Guy's and St Thomas' NHS Foundation Trust |
|
|
NSCCG |
National Study of Colorectal Cancer Genetics |
Dr M Wise |
Institute of Cancer Research | |
| qFit | A new test for ruling out colorectal cancer - The qFIT Pilot | Dr J Collum | University College London | University College Hospital website |
|
RAIDER |
A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder |
Dr O Parikh |
Institute of Cancer Research | |
|
Rapper |
Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy |
Dr Charnley |
University of Manchester | NHS choices |
|
SEARCH |
A population based study of genetic predispositions and gene-environment interactions in cancer (ovarian and endometrial) |
Dr M Hogg |
Cancer Research UK | |
|
Stampede |
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy |
Dr O Parikh |
Medical Research Council | |
|
True NTH UK (post surgery follow-up) |
Development and evaluation of a patient-reported instrument to monitor oncological and functional outcomes after radical prostatectomy (prostate) |
Mr S Srirangham |
University College London | |
|
UKGPC study |
UK Genetic Prostate Cancer Study |
Dr O Parikh |
The Institute of Cancer Research |
Last updated 5th December 2018
Critical care
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
|
ASPIRE ICU |
Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa infection in Europe |
Dr S Long |
Cardiff and Vale UHB |
|
|
PQIP |
Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme |
Dr M Pollard |
University College London | |
|
PRISM |
Prevention of Respiratory Insufficiency after Surgical Management Trial |
Dr S Chukkambotla |
Queen Mary University of London | |
|
The “65” Trial |
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension |
Dr J Roberts |
Intensive Care National Audit and Research Centre (ICNARC) | |
|
The REST study |
Protective ventilation with veno-venous lung assist in respiratory failure |
Dr S Chukkambotla |
Belfast Health & Social Care Trust |
|
Last checked 7th September 2018
Diabetes, stroke, heart and blood vessel disease
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
ADDRESS-2 |
An incident and high risk type 1 diabetes research cohort: After Diagnosis Diabetes REsearch Support System-2 |
Diabetes |
Dr A Del Rio |
Imperial College of Science, Technology and Medicine | |
| MASTER DAPT | MAnagement of high bleeding risk patients post bioresorbable polymer coated STEnt implantation with an abbReviated versus prolonged DAPT regimen | Diabetes | Dr J McDonald | European Cardiovascular Research Institute (ECRI) | ECRI study webpage |
|
MYDIABETES |
A cross-sectional |
Diabetes |
Dr S Ramtoola |
Imperial College of Science, Technology and Medicine |
|
|
StartRight |
Getting the right classification and treatment from diagnosis of diabetes |
Diabetes |
Dr S Ramtoola |
Royal Devon and Exeter NHS Foundation Trust |
|
|
ATAM - Developing and validating a therapeutic alliance measure |
Aphasia Therapeutic Alliance Measure (ATAM): Development and preliminary psychometric evaluation |
Stroke |
Catherine Curley |
University of Manchester |
|
|
BRAINS |
British repository of DNA in stroke: towards the identification of new drug targets |
Stroke |
Dr N Goorah |
Imperial College Healthcare NHS Trust | |
| CONVINCE | COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke | Stroke | Dr A Singh | University College Dublin | |
|
RESTART |
REstart or STop Antithrombotics Randomised Trial |
Stroke |
Dr N Goorah |
University of Edinburgh & NHS Lothian | |
|
LLIFT |
Pilot study to test the clinical efficacy of FlowOx™ home treatment compared to standard care in patients with critical limb ischemia and lower limb ulcers |
Heart |
Mr Simon Hardy |
University of Salford |
|
|
MILES-UK |
MILES - UK: Post Marketing, Multicenter, Single Arm, Observational Clinical Registry to Evaluate Safety and Efficacy of BioMime Sirolimus Eluting Stent System In All Comers Real World Population With Coronary Artery Stenosis in United Kingdom |
Heart |
Dr Balachandran |
Meril Life Sciences Pvt Ltd |
|
|
UK GRIS |
Effectiveness of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome |
Heart |
Dr S Garg |
University of Leeds |
Last updated 26th September 2018
Ear, nose and throat, infectious diseases, eyes and lungs
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
Characterisation of subretinal hyper-reflective material in nAMD |
The characterisation of subretinal hyper-reflective material using Heidelberg Optical Coherence Tomography and Heidelberg Multicolour imaging in neovascular age-related macular degeneration |
Eyes |
Dr Z Al-Moasseb |
East Lancashire Hospitals NHS Trust |
|
|
Stereotactic radiotherapy for wet AMD (STAR) |
StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): A randomised, double-masked, sham-controlled, clinical trial comparing low-voltage X-ray irradiation with as needed ranibizumab, to as needed ranibizumab monotherapy |
Eyes |
Mrs S Abugreen |
Kings College London |
|
|
VICI |
Clinical efficacy and mechanistic evaluation of Eplerenone for central serous chorio-retinopathy - the VICI randomised trial |
Eyes |
Mrs S Abugreen |
University Hospital Southampton NHS Foundation Trust | |
|
NATTINA |
The National Trial of tonsillectomy in Adults: a clinical and cost effectiveness study |
Throat |
Mr Surya Narayan |
Newcastle Upon Tyne Hospitals NHS Foundation Trust |
|
|
EMBARC: European Bronchiectasis Registry |
The EMBARC European Bronchiectasis Registry |
Lung |
Dr I Crossingham |
NHS Tayside |
|
Last checked 7th September 2018
Skin, muscle, bone and connective tissue disorders
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
AIR: Ankle Injury Rehabilitation |
Ankle Injury Rehabilitation - Comparing plaster cast to functional brace in the rehabilitation of ankle fractures |
Musculoskeletal |
Mr A Zubairy |
University of Warwick | |
|
BILAG-2004 VALIDATION |
Validation of BILAG2004 index for assessment of disease activity in systemic lupus erythematosus |
Musculoskeletal |
Dr L Teh |
|
|
|
Dupuytren’s Interventions Surgery vs. Collagenase (DISC) |
A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients |
Musculoskeletal |
Dr F Younis |
University Hospitals of Leicester NHS Trust | |
|
GRASP |
GRASP: Getting it Right: Addressing Shoulder Pain. Clinical and cost effectiveness of progressive exercise compared to best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: a 2x2 factorial randomised controlled trial |
Musculoskeletal |
Dr A Hallett, Helen Thompson |
University of Oxford | |
|
PREVENT-RA |
PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis |
Musculoskeletal |
Dr L Teh |
University of Manchester | |
|
TOXICITY FROM BIOLOGIC THERAPY (BSRBR) |
Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis |
Musculoskeletal |
Dr L Teh |
University of Leeds | |
|
USEFUL |
UltraSound Evaluation For mUsculoskeletal Lupus |
Musculoskeletal |
Dr L Teh |
University of Leeds |
|
|
|
Hammer toecorrection with excision arthroplasty |
Musculoskeletal |
Ms V Sinclair |
|
|
|
OARS |
The Outcomes in Ankle Replacement Study (OARS) A study of patient-reported outcome following total ankle replacement based on data from the National Joint Registry (NJR) for England and Wales. |
Musculoskeletal |
Mr A Zubairy |
University of East Anglia |
|
|
BADBIR |
British Association of Dermatologists Biologic Interventions Register |
Skin |
Dr B Daly |
University of Manchester | |
|
B-STOP |
A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis |
Skin |
Dr Owen |
Guy's and St Thomas' NHS Foundation Trust |
|
Last updated 7th September 2018
Surgery
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
|
DRAFFT 2 |
DRAFFT 2: Distal Radius Acute Fracture Fixation Trial - A Randomised Controlled Trial of Manipulation and surgical fixation with K-wires versus Manipulation and Casting in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius |
Mr M Srinivasan |
University of Oxford | |
|
HIP study |
Hartmann’s procedure versus Intersphincteric APE |
Mr A Sheikh |
Countess of Chester Hospital NHS Foundation Trust |
|
|
PPAC2 - Packing of Perianal Abscess Cavities 2 |
The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial |
Miss J Smith |
Manchester University NHS Foundation Trust | |
|
PUrE |
The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT Percutaneous nephrolithotomy (PNL), flexible Ureterorenoscopy (FURS) and Extracorporeal lithotripsy (ESWL) for lower pole kidney stones |
Mr S Srirangam |
University of Aberdeen |
Last checked 7th September 2018
Urology
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
|
AUSD |
A prospective assessment of the economic and quality of life impact of acute urinary stone disease in a district general hospital catchment population |
Dr Srirangam |
East Lancashire Hospitals NHS Trust |
Last checked 7th September 2018
Women, newborn and children’s research
You may need to talk to your doctor or midwife about taking part in the studies listed here.
If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact the women's health research team:
Burnley General Hospital: 01282 803081
Royal Blackburn Hospital: 01254 732650
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
BIOJUME |
Biology of Juvenile Myoclonic Epilepsy |
Children |
Dr R Belderbos |
Kings College London | |
| CF Start |
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial |
Children | Dr D Corbett | Alder Hey Childrens NHS FT | CF START website |
|
EU Patch |
EU Patch: The role of glasses wearing in amblyopia treatment |
Children |
Mrs M Mohan |
University of Leicester | |
|
Prednos 2 |
Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study. |
Children |
Dr J Iqbal |
University of Birmingham | |
|
RaDaR |
National Studies of Rare Kidney Diseases |
Children |
Dr J Iqbal |
Medical Research Council | |
| REGAIN | Rolandic Epilepsy Genomewide Association International Study (REGAIN) |
Children | Dr R Belderbos | King’s College London and King’s College Hospital NHS Trust | Childhood Epilepsy.org website |
|
UK ITP registry |
The UK Paediatric ITP Registry |
Children, |
Dr V Holme |
Royal Manchester Children's Hospital | |
|
ADDRESS-2 |
An incident and high risk type 1 diabetes research cohort: After Diagnosis Diabetes REsearch Support System-2 (ADDRESS-2) |
Children, diabetes |
Dr A Del Rio |
Imperial College of Science, Technology and Medicine | |
|
TrialNet LIFT Study |
Long Term investigative Follow-up in TrialNet (LIFT) |
Children, diabetes |
Dr Ramtoola |
University of Bristol | |
|
Trialnet (pathway to prevention study) |
Natural history study of the development of type I diabetes, phase 1, 2 and 3 |
Children, diabetes |
Dr C Gardner |
University of Bristol | |
|
BabyOSCAR |
Outcome after Selective early treatment for Closure of patent ductus ARteriosus in pre-term babies |
Neonatal |
Dr N Soni |
University of Oxford | |
| Better care pathways in pregnancies after stillbirth | Reproduction | Cathie Melvin | The University of Manchester | UK Clinical Trials Gateway | |
| Big baby trial | Induction of labour for predicted macrosomia ‘The Big Baby Trial’ | Reproduction | Dr S Davies | University Hospitals Coventry and Warwickshire NHS Trust | UK Clinical Trials Gateway |
|
C-STICH |
The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH) |
Reproduction |
Mrs E Martindale |
Birmingham Women's NHS Foundation Trust | |
|
GAPP2 |
A multi-centre randomised controlled trial of the efficacy and mechanism of action of gabapentin for the management of chronic pelvic pain in women |
Reproduction |
Mrs K Bhatia |
University of Edinburgh | |
|
GEM3 |
A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy |
Reproduction |
Dr F Clarke |
NHS Lothian | |
|
LATITUDE |
An observational study of patient choice and the use of the urethral bulking agent Bulkamid, as a first line treatment for stress urinary incontinence and the effect on a subsequent mid urethral sling |
Reproduction |
Mr Simon Hill |
Central Manchester University Hospitals NHS Foundation Trust |
|
| MifeMiso | A randomised, placebo-controlled trial of mifepristone and misoprostol versus misoprostol alone in the medical management of missed miscarriage | Reproduction | Mrs K Bhatia | University of Birmingham | Birmingham Clinical Trials Unit website |
|
MiQuit3 |
RCT and meta analysis testing effectiveness and cost-effectiveness of a tailored text message programme (MiQuit) for smoking cessation in pregnancy |
Reproduction |
Cathie Melvin |
University of Nottingham |
|
|
PIP |
Pipelle for pregnancy (PIP) studies |
Reproduction |
Mrs S Nethra |
Auckland District Health Board (New Zealand) |
|
|
PREP |
Helping Pregnant smokers to quit: A multi-centre RCT of electronic cigarettes vs. nicotine patches (usual care) |
Reproduction |
Mr M Maher |
Queen Mary University of London |
|
|
SERENITY |
A phase 2a, randomized, double-blind, placebo-controlled, |
Reproduction |
Mr S Hill |
Astellas Pharma Europe B.V. | |
|
STOPPIT 2 |
An open randomised trial of the Arabin pessary to prevent preterm birth in twin pregnancy, with health economics and acceptability |
Reproduction |
Dr J Nugent |
University of Edinburgh |
Last updated 4th December 2018
Finding research studies on the internet
Clinical research studies happening locally and nationally can be found by searching the following databases:
- UK Clinical Trials Gateway
- Join dementia research
- Research for the future (for patients with diabetes, heart, lung and kidney disease)
