Current Studies :: East Lancashire Hospitals NHS Trust

Anaesthetics and pain

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Local researcher	Sponsor	Further information
ASCRIBED	The impact of Acute Systematic inflammation upon cerebrospinal fluid and blood Biomarkers of brain inflammation and injury in Dementia: a study in acute hip fracture patients	Dr A Shannon	University of East Anglia
Improving Tracheostomy Care	Improving Tracheostomy Care - National Quality Improvement Programme	Dr M Atkinson	University Hospital of South Manchester NHS Foundation Trust
PQIP	Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme	Dr M Pollard	University College London	PQIP website

Last amended 13th June 2018

Cancer, including cancers of the blood

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of our cancer studies, please contact the cancer research team on 01254 733299.

Short title	Description	Local researcher	Sponsor	Find out more
B-AHEAD3	Breast Activity and Healthy Eating After Diagnosis 3	Dr M Hogg		Cancer Research UK website
Breast Tomosynthesis	Accuracy of Fuji Amulet DBT views versus standard mammographic views for the diagnosis of soft tissue breast lesions (excluding microcalcification)	Dr S Ahmad
Bridging the Age Gap in Breast Cancer	Bridging the Age Gap in Breast Cancer: Improving Outcomes for Older Women	Miss Iddon	Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust	Cancer Research UK website
CIPHER	UK cohort study to investigate the prevention of parastomal hernia	Mr L Jones		UK Clinical Trials Gateway
CTC in pancreatic cancer (AST1) *study not recruiting patients at the moment	Feasibility study of detection of circulating tumour cells (CTC) and circulating mRNA in patients with pancreatic cancer as a means of earlier diagnosis	Mr D Chang		Cancer Research UK website
DETECT II	A multi-centre observational study design to determine the sensitivity of the UroMark assay, a urine test, to detect new and recurrent low, intermediate and high-grade bladder cancer	Dr Srirangam	University College London	UK Clinical Trials Gateway website
ESPAC-4	EUROPEAN STUDY GROUP FOR PANCREATIC CANCER - TRIAL 4. Combination versus single agent chemotherapy in resectable pancreatic ductal and peri-ampullary cancers	Mr D Chang	University of Liverpool	Cancer Research UK website
HORIZONS	HORIZONS: Understanding the impact of cancer diagnosis and treatment on everyday life (breast, gynaecological cancer and non Hodgkin lymphoma)	K Jewers	University Hospital Southampton NHS Foundation Trust	Horizons study website
ICON8B	A phase III randomised trial investigating the combination of dose fractionated chemotherapy and bevacizumab compared to either strategy alone for the first-line treatment of women with newly diagnosed high risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer	Dr Hogg		ICON8 trials programme website
IPATential 150 prostate study	A phase III, randomised, double-blind, placebo controlled multi-centre trial testing Ipatasertib plus Abiraterone plus Prednisone/Prednisolone relative to placebo plus abiraterone plus prednisone/prednisolone in adult male patients with asymptomatic or mildly symptomatic, previously untreated, metastatic castrate-resistant prostate cancer	Dr O Parikh	Hoffman - La Roche Ltd
Measures	The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative Neoplasms	Dr Adiyodi	Guy's and St Thomas' NHS Foundation Trust
NSCCG	National Study of Colorectal Cancer Genetics	Dr M Wise		Cancer Research UK website
Prima	A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Niraparib Maintenance Treatment in Patients with Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy	Dr Badea	Tesaro Inc	Target Ovarian Cancer website
RAIDER	A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder	Dr O Parikh	Institute of Cancer Research	Cancer Research UK website
Rapper	Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy	Dr Charnley	University of Manchester	Rapper study website
SEARCH	A population based study of genetic predispositions and gene-environment interactions in cancer (ovarian and endometrial)	Dr M Hogg		Cancer Research UK website
Stampede	Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy	Dr O Parikh	Medical Research Council	Cancer Research UK website
TOPARP	TOPARP: Phase II Trial of Olaparib in Patients with Advanced Castration Resistant Prostate Cancer	Dr O Parikh	Royal Marsden NHS Foundation Trust	Cancer Research UK website
True NTH UK (post surgery follow-up)	Development and evaluation of a patient-reported instrument to monitor oncological and functional outcomes after radical prostatectomy (prostate)	Mr S Srirangham	University College London	UK Clinical Trials Gateway
UKGPC study	UK Genetic Prostate Cancer Study	Dr O Parikh		The Institute of Cancer Research website Cancer Research UK website

Last amended13th June 2018

Critical care

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Local researcher	Sponsor	Further information
ASPIRE ICU	Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa infection in Europe	Dr S Long	Cardiff and Vale UHB
PQIP	Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme	Dr M Pollard	University College London	PQIP website
PRISM	Prevention of Respiratory Insufficiency after Surgical Management Trial	Dr S Chukkambotla	Queen Mary University of London	PRISM trial website
The “65” Trial	Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension	Dr J Roberts	Intensive Care National Audit and Research Centre (ICNARC)	UK Clinical Trials Gateway
The REST study	Protective ventilation with veno-venous lung assist in respiratory failure	Dr S Chukkambotla	Belfast Health & Social Care Trust

Last amended13th June 2018

Diabetes, stroke, heart and blood vessel disease

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Patient group	Local Researcher	Sponsor	Find out more
ADDRESS-2	An incident and high risk type 1 diabetes research cohort: After Diagnosis Diabetes REsearch Support System-2	Diabetes	Dr A Del Rio	Imperial College of Science, Technology and Medicine	ADDRESS-2 study website
MYDIABETES	A cross-sectional study to characterise young onset diabetes in two UK ethnic groups	Diabetes	Dr S Ramtoola	Imperial College of Science, Technology and Medicine
StartRight	Getting the right classification and treatment from diagnosis of diabetes	Diabetes	Dr S Ramtoola	Royal Devon and Exeter NHS Foundation Trust
ATAM - Developing and validating a therapeutic alliance measure	Aphasia Therapeutic Alliance Measure (ATAM): Development and preliminary psychometric evaluation	Stroke	Catherine Curley	University of Manchester
BRAINS	British repository of DNA in stroke: towards the identification of new drug targets	Stroke	Dr N Goorah	Imperial College Healthcare NHS Trust	The BRAINS study website
RESTART	REstart or STop Antithrombotics Randomised Trial	Stroke	Dr N Goorah		The RESTART trial website
AFGEN UK	EURObservational Research Programme: Long-term Registry on Patients with Atrial Fibrillation (AFGEN)	Heart	Dr S Garg	University of Birmingham
3708 CARD e-ULTIMASTER Registry	Prospective,single-arm, multi-centre, observational registry to further validate safety and efficacy of the ultimaster DES in real-world patients.	Heart	Dr J McDonald	Terumo UK Ltd
LLIFT	Pilot study to test the clinical efficacy of FlowOx™ home treatment compared to standard care in patients with critical limb ischemia and lower limb ulcers	Heart	Mr Simon Hardy
MILES-UK	MILES - UK: Post Marketing, Multicenter, Single Arm, Observational Clinical Registry to Evaluate Safety and Efficacy of BioMime Sirolimus Eluting Stent System In All Comers Real World Population With Coronary Artery Stenosis in United Kingdom	Heart	Dr Balachandran	Meril Life Sciences Pvt Ltd
Ripcord 2	A randomised controlled trial to compare routine pressure wire assessment with conventional angiography in the management of patients with coronary artery disease	Heart	Dr Garg	University Hospital Southampton NHS Foundation Trust	UK Clinical Trials Gateway
UK GRIS	Effectiveness of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome	Heart	Dr S Garg	University of Leeds	UK Clinical Trials Gateway website

Last amended 13th June 2018

Ear, nose and throat, infectious diseases, eyes and lungs

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Patient group	Local researcher	Sponsor	Find out more
Characterisation of subretinal hyper-reflective material in nAMD	The characterisation of subretinal hyper-reflective material using Heidelberg Optical Coherence Tomography and Heidelberg Multicolour imaging in neovascular age-related macular degeneration	Eyes	Dr Z Al-Moasseb
Stereotactic radiotherapy for wet AMD (STAR)	StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): A randomised, double-masked, sham-controlled, clinical trial comparing low-voltage X-ray irradiation with as needed ranibizumab, to as needed ranibizumab monotherapy	Eyes	Mrs S Abugreen	Kings College London
VICI	Clinical efficacy and mechanistic evaluation of Eplerenone for central serous chorio-retinopathy - the VICI randomised trial	Eyes	Mrs S Abugreen		UK Clinical Trials Gateway
NATTINA	The National Trial of tonsillectomy in Adults: a clinical and cost effectiveness study	Throat	Mr Surya Narayan	Newcastle Upon Tyne Hospitals NHS Foundation Trust
EMBARC: European Bronchiectasis Registry	The EMBARC European Bronchiectasis Registry	Lung	Dr I Crossingham	NHS Tayside

Last amended 13th June 2018

Skin, muscle, bone and connective tissue disorders

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Patient group	Local researcher	Sponsor	Find out more
AIR: Ankle Injury Rehabilitation	Ankle Injury Rehabilitation - Comparing plaster cast to functional brace in the rehabilitation of ankle fractures	Musculoskeletal	Mr A Zubairy		Warwick Clinical Trials Unit website
BILAG-2004 VALIDATION	Validation of BILAG2004 index for assessment of disease activity in systemic lupus erythematosus	Musculoskeletal	Dr L Teh
Dupuytren’s Interventions Surgery vs. Collagenase (DISC)	A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients	Musculoskeletal	Dr F Younis		UK Clinical Trials Gateway
GRASP	GRASP: Getting it Right: Addressing Shoulder Pain. Clinical and cost effectiveness of progressive exercise compared to best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: a 2x2 factorial randomised controlled trial	Musculoskeletal	Dr A Hallett, Helen Thompson	University of Oxford	GRASP study website
PREVENT-RA	PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis	Musculoskeletal	Dr L Teh	University of Manchester	PREVeNT RA website
RAMS	Rheumatoid Arthritis Medication Study (RAMS): Predicting response to DMARDs in rheumatoid arthritis	Musculoskeletal	Dr L Teh	University of Manchester
TOXICITY FROM BIOLOGIC THERAPY (BSRBR)	Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis	Musculoskeletal	Dr L Teh		University of Manchester BSRBR-RA study website
USEFUL	UltraSound Evaluation For mUsculoskeletal Lupus	Musculoskeletal	Dr L Teh	University of Leeds
	Hammer toecorrection with excision arthroplasty	Musculoskeletal	Ms V Sinclair
OARS	The Outcomes in Ankle Replacement Study (OARS) A study of patient-reported outcome following total ankle replacement based on data from the National Joint Registry (NJR) for England and Wales.	Musculoskeletal	Mr A Zubairy	University of East Anglia
BADBIR	British Association of Dermatologists Biologic Interventions Register	Skin	Dr B Daly	University of Manchester	BADBIR study website
B-STOP	A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis	Skin	Dr Owen	Guy's and St Thomas' NHS Foundation Trust

Last amended 13th June 2018

Surgery

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Local researcher	Sponsor	Find out more
DRAFFT 2	DRAFFT 2: Distal Radius Acute Fracture Fixation Trial - A Randomised Controlled Trial of Manipulation and surgical fixation with K-wires versus Manipulation and Casting in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius	Mr M Srinivasan	University of Oxford	University of Oxford website
HIP study	Hartmann’s procedure versus Intersphincteric APE	Mr A Sheikh	Countess of Chester Hospital NHS Foundation Trust
PPAC2 - Packing of Perianal Abscess Cavities 2	The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial	Miss J Smith		North West Research Collaborative website
PUrE	The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT Percutaneous nephrolithotomy (PNL), flexible Ureterorenoscopy (FURS) and Extracorporeal lithotripsy (ESWL) for lower pole kidney stones	Mr S Srirangam	University of Aberdeen	PUrE study website

Last amended 13th June 2018

Urology

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title	Description	Local researcher	Sponsor	Find out more
AUSD	A prospective assessment of the economic and quality of life impact of acute urinary stone disease in a district general hospital catchment population	Dr Srirangam

Last amended 13th June 2018

Women, newborn and children’s research

You may need to talk to your doctor or midwife about taking part in the studies listed here.

If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact the women's health research team:

Burnley General Hospital: 01282 803081

Royal Blackburn Hospital: 01254 732650

Short title	Description	Patient group	Local Researcher	Sponsor	Find out more
BIOJUME	Biology of Juvenile Myoclonic Epilepsy	Children	Dr R Belderbos	Kings College London	Childhood Epilepsy website
EU Patch	EU Patch: The role of glasses wearing in amblyopia treatment	Children	Mrs M Mohan	University of Leicester	UK Clinical Trials Gateway
Prednos 2	Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study.	Children	Dr J Iqbal	University of Birmingham	Prednos 2 study website
RaDaR	National Studies of Rare Kidney Diseases	Children	Dr J Iqbal	Medical Research Council	Rare Renal website
UK ITP registry	The UK Paediatric ITP Registry	Children,	Dr V Holme	Royal Manchester Children's Hospital	UK Paediatric ITP Working Party website
ADDRESS-2	An incident and high risk type 1 diabetesresearch cohort: After Diagnosis Diabetes REsearch Support System-2 (ADDRESS-2)	Children, diabetes	Dr A Del Rio	Imperial College of Science, Technology and Medicine	ADDRESS-2 study website
TrialNet LIFT Study	Long Term investigative Follow-up in TrialNet (LIFT)	Children, diabetes	Dr Ramtoola		Trialnet study website
Trialnet (pathway to prevention study)	Natural history study of the development of type I diabetes, phase 1, 2 and 3	Children, diabetes	Dr C Gardner	University of Bristol	Trialnet study website
BabyOSCAR	Outcome after Selective early treatment for Closure of patent ductus ARteriosus in pre-term babies	Neonatal	Dr N Soni	University of Oxford	National Perinatal Epidemiology Unit website
OPTI-Prem	Optimising neonatal service provision for preterm babies born between 27 and 31 weeks of gestation in England, using national data, qualitative research and economic analysis.	Neonatal	Royal Wolverhampton NHS Trust		OPTI-Prem webpages
ANODE	prophylactic ANtibiotics for the prevention of infection following Operative DElivery	Reproduction	Mrs M Golash	University of Oxford	National Perinatal Epidemiology Unit website
	Better care pathways in pregnancies after stillbirth	Reproduction	Cathie Melvin
C-STICH	The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH)	Reproduction	Mrs E Martindale	Birmingham Women's NHS Foundation Trust	Birmingham Clinical Trials Unit Website
GAPP2	A multi-centre randomised controlled trial of the efficacy and mechanism of action of gabapentin for the management of chronic pelvic painin women	Reproduction	Mrs K Bhatia	University of Edinburgh	Birmingham Clinical Trials Unit website
GEM3	A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy	Reproduction	Dr F Clarke	NHS Lothian	Birmingham Clinical Trials Unit
LATITUDE	An observational study of patient choice and the use of the urethral bulking agent Bulkamid, as a first line treatment for stress urinary incontinence and the effect on a subsequent mid urethral sling	Reproduction	Mr Simon Hill	Central Manchester University Hospitals NHS Foundation Trust
MifeMiso	A randomised, placebo-controlled trial of mifepristone and misoprostol versus misoprostol alone in the medical management of missed miscarriage	Reproduction	Mrs K Bhatia		Birmingham Clinical Trials Unit website
MiQuit3	RCT and meta analysis testing effectiveness and cost-effectiveness of a tailored text message programme (MiQuit) for smoking cessation in pregnancy	Reproduction	Cathie Melvin	University of Nottingham
PIP	Pipelle for pregnancy (PIP) studies	Reproduction	Mrs S Nethra	Auckland District Health Board (New Zealand)
PITCHES	Phase III trial in Intrahepatic Cholestasis of Pregnancy (ICP) to Evaluate ursodeoxycholic acid (UDCA) in improving perinatal outcomes	Reproduction	Mrs C Schram	Kings College London	PITCHES trial website
PREP	Helping Pregnant smokers to quit: A multi-centre RCT of electronic cigarettes vs. nicotine patches (usual care)	Reproduction	Mr M Maher	Queen Mary University of London
SERENITY	A phase 2a, randomized, double-blind, placebo-controlled, parallel-group, proof of concept study to investigate efficacy, safety, pharmacodynamics and pharmacokinetics of ASP6294 in the treatment of female subjects with bladder pain syndrome/interstitial cystitis	Reproduction	Mr S Hill		UK Clinical Trials Gateway
STOPPIT 2	An open randomised trial of the Arabin pessary to prevent preterm birth in twin pregnancy, with health economics and acceptability	Reproduction	Dr J Nugent	University of Edinburgh	STOPPIT 2 trial website