The clinical research studies currently available to patients at East Lancashire Hospitals NHS Trust are listed below:

Anaesthetics and pain

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Further information

ASCRIBED

The impact of Acute Systematic inflammation upon cerebrospinal fluid and blood Biomarkers of brain inflammation and injury in Dementia: a study in acute hip fracture patients

Dr A Shannon

University of East Anglia

 

Improving Tracheostomy Care

Improving Tracheostomy Care - National Quality Improvement Programme

Dr M Atkinson

University Hospital of South Manchester NHS Foundation Trust

 

PQIP

Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme

Dr M Pollard

University College London

PQIP website

 Last checked 7th September 2018

Cancer, including cancers of the blood

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of our cancer studies, please contact the cancer research team on 01254 733299.

Short title

Description

Local researcher

Sponsor

Find out more

ACE A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) Dr Parikh University Hospitals Bristol NHS Trust  

Breast Tomosynthesis

Accuracy of Fuji Amulet DBT views versus standard mammographic views for the diagnosis of soft tissue breast lesions (excluding microcalcification)

Dr S Ahmad

East Lancashire Hospitals NHS Trust

 

CIPHER UK cohort study to investigate the prevention of parastomal hernia Mr L Jones Royal Devon & Exeter NHS Foundation Trust UK Clinical Trials Gateway

HORIZONS

HORIZONS: Understanding the impact of cancer diagnosis and treatment on everyday life (breast, gynaecological cancer and non Hodgkin lymphoma)

K Jewers

University Hospital Southampton NHS Foundation Trust

Horizons study website

 

IPATential 150 prostate study

A phase III, randomised, double-blind, placebo controlled multi-centre trial testing Ipatasertib plus Abiraterone plus Prednisone/Prednisolone 
relative to placebo plus abiraterone plus prednisone/prednisolone in adult male patients with asymptomatic or mildly symptomatic, previously untreated, metastatic castrate-resistant prostate cancer 

Dr O Parikh

Hoffman - La Roche Ltd

 

Measures

The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative Neoplasms

Dr Adiyodi

Guy's and St Thomas' NHS Foundation Trust

 

NSCCG

National Study of Colorectal Cancer Genetics

Dr M Wise

Institute of Cancer Research

Cancer Research UK website

qFit A new test for ruling out colorectal cancer - The qFIT Pilot Dr J Collum University College London University College Hospital website

RAIDER

A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder

Dr O Parikh

Institute of Cancer Research

Cancer Research UK website

Rapper

Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy

Dr Charnley

University of Manchester NHS choices

SEARCH

A population based study of genetic predispositions and gene-environment interactions in cancer (ovarian and endometrial)

Dr M Hogg

Cancer Research UK

Cancer Research UK website

Stampede

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy

Dr O Parikh

Medical Research Council

Cancer Research UK website

True NTH UK

(post surgery follow-up)

Development and evaluation of a patient-reported instrument to monitor oncological and functional outcomes after radical prostatectomy (prostate)

Mr S Srirangham

University College London

UK Clinical Trials Gateway

UKGPC study

UK Genetic Prostate Cancer Study

Dr O Parikh

The Institute of Cancer Research

The Institute of Cancer Research website

Cancer Research UK website

Last updated 5th December 2018

Critical care

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title 

Description 

Local researcher 

Sponsor

Further information 

ASPIRE ICU

Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa infection in Europe

Dr S Long

Cardiff and Vale UHB

 

PQIP

Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme

Dr M Pollard

University College London

PQIP website

PRISM

Prevention of Respiratory Insufficiency after Surgical Management Trial

Dr S Chukkambotla

Queen Mary University of London

PRISM trial website

The “65” Trial

Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension

Dr J Roberts

Intensive Care National Audit and Research Centre (ICNARC)

UK Clinical Trials Gateway

The REST study

Protective ventilation with veno-venous lung assist in respiratory failure

Dr S Chukkambotla

Belfast Health & Social Care Trust

 

Last checked 7th September 2018

Diabetes, stroke, heart and blood vessel disease

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local Researcher

Sponsor

Find out more

ADDRESS-2

An incident and high risk type 1 diabetes research cohort: After Diagnosis Diabetes REsearch Support System-2

Diabetes

Dr A Del Rio

Imperial College of Science, Technology and Medicine

ADDRESS-2 study website

MASTER DAPT MAnagement of high bleeding risk patients post bioresorbable polymer coated STEnt implantation with an abbReviated versus prolonged DAPT regimen Diabetes Dr J McDonald European Cardiovascular Research Institute (ECRI) ECRI study webpage

MYDIABETES

A cross-sectional
study to characterise young onset
diabetes in two UK ethnic groups

Diabetes

Dr S Ramtoola

Imperial College of Science, Technology and Medicine

 

StartRight

Getting the right classification and treatment from diagnosis of diabetes

Diabetes

Dr S Ramtoola

Royal Devon and Exeter NHS Foundation Trust

 

ATAM - Developing and validating a therapeutic alliance measure

Aphasia Therapeutic Alliance Measure (ATAM): Development and preliminary psychometric evaluation

Stroke

Catherine Curley

University of Manchester

 

BRAINS

British repository of DNA in stroke: towards the identification of new drug targets

Stroke

Dr N Goorah 

Imperial College Healthcare NHS Trust

The BRAINS study website

CONVINCE COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke Stroke Dr A Singh University College Dublin  

RESTART

REstart or STop Antithrombotics Randomised Trial

Stroke

Dr N Goorah 

University of Edinburgh & NHS Lothian

The RESTART trial website

LLIFT

Pilot study to test the clinical efficacy of FlowOx™ home treatment compared to standard care in patients with critical limb ischemia and lower limb ulcers

Heart

Mr Simon Hardy

University of Salford

 

MILES-UK

MILES - UK: Post Marketing, Multicenter, Single Arm, Observational Clinical Registry to Evaluate Safety and Efficacy of BioMime Sirolimus Eluting Stent System In All Comers Real World Population With Coronary Artery Stenosis in United Kingdom

Heart

Dr Balachandran

Meril Life Sciences Pvt Ltd

 

UK GRIS

Effectiveness of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome 

Heart

Dr S Garg

University of Leeds

UK Clinical Trials Gateway website

Last updated 26th September 2018

Ear, nose and throat, infectious diseases, eyes and lungs

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

Characterisation of subretinal hyper-reflective material in nAMD

The characterisation of subretinal hyper-reflective material using Heidelberg Optical Coherence Tomography and Heidelberg Multicolour imaging in neovascular age-related macular degeneration

Eyes

Dr Z Al-Moasseb

East Lancashire Hospitals NHS Trust

 

Stereotactic radiotherapy for wet AMD (STAR)

StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): A randomised, double-masked, sham-controlled, clinical trial comparing low-voltage X-ray irradiation with as needed ranibizumab, to as needed ranibizumab monotherapy

Eyes

Mrs S Abugreen

Kings College London

 

VICI

Clinical efficacy and mechanistic evaluation of Eplerenone for central serous chorio-retinopathy - the VICI randomised trial

Eyes 

Mrs S Abugreen

University Hospital Southampton NHS Foundation Trust 

UK Clinical Trials Gateway 

NATTINA

The National Trial of tonsillectomy in Adults: a clinical and cost effectiveness study

Throat

Mr Surya Narayan 

Newcastle Upon Tyne Hospitals NHS Foundation Trust

 

EMBARC: European Bronchiectasis Registry

The EMBARC European Bronchiectasis Registry

Lung

Dr I Crossingham

NHS Tayside

 

Last checked 7th September 2018

Skin, muscle, bone and connective tissue disorders

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

AIR: Ankle Injury Rehabilitation

Ankle Injury Rehabilitation - Comparing plaster cast to functional brace in the rehabilitation of ankle fractures

Musculoskeletal

Mr A Zubairy 

University of Warwick

Warwick Clinical Trials Unit website

BILAG-2004 VALIDATION

Validation of BILAG2004 index for assessment of disease activity in systemic lupus erythematosus

Musculoskeletal

Dr L Teh

 

 

Dupuytren’s Interventions Surgery vs. Collagenase (DISC)

A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients

Musculoskeletal

Dr F Younis

University Hospitals of Leicester NHS Trust

UK Clinical Trials Gateway

GRASP

GRASP: Getting it Right: Addressing Shoulder Pain. Clinical and cost effectiveness of progressive exercise compared to best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: a 2x2 factorial randomised controlled trial

Musculoskeletal

Dr A Hallett, Helen Thompson

University of Oxford

GRASP study website

PREVENT-RA

PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis

Musculoskeletal

Dr L Teh

University of Manchester

PREVeNT RA website

TOXICITY FROM BIOLOGIC THERAPY (BSRBR)

Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis

Musculoskeletal

Dr L Teh

University of Leeds

University of Manchester BSRBR-RA study website

USEFUL

UltraSound Evaluation For mUsculoskeletal Lupus

Musculoskeletal

Dr L Teh

University of Leeds

 

 

Hammer toecorrection with excision arthroplasty

Musculoskeletal

Ms V Sinclair

 

 

OARS

The Outcomes in Ankle Replacement Study (OARS) A study of patient-reported outcome following total ankle replacement based on data from the National Joint Registry (NJR) for England and Wales.

Musculoskeletal

Mr A Zubairy

University of East Anglia

 

BADBIR

British Association of  Dermatologists Biologic Interventions Register

Skin

Dr B Daly

University of Manchester

BADBIR study website

B-STOP

A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis

Skin

Dr Owen

Guy's and St Thomas' NHS Foundation Trust

 

Last updated 7th September 2018

Surgery

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Find out more

DRAFFT 2

DRAFFT 2: Distal Radius Acute Fracture Fixation Trial - A Randomised Controlled Trial of Manipulation and surgical fixation with K-wires versus Manipulation and Casting in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius

Mr M Srinivasan

University of Oxford

University of Oxford website

HIP study

Hartmann’s procedure versus Intersphincteric APE

Mr A Sheikh

Countess of Chester Hospital NHS Foundation Trust

 

PPAC2 -  Packing of Perianal Abscess Cavities 2

The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial

Miss J Smith

Manchester University NHS Foundation Trust

North West Research Collaborative website

PUrE

The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT Percutaneous nephrolithotomy (PNL), flexible Ureterorenoscopy (FURS) and Extracorporeal lithotripsy (ESWL) for lower pole kidney stones

Mr S Srirangam

University of Aberdeen

PUrE study website

Last checked 7th September 2018

Urology

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Find out more

AUSD

A prospective assessment of the economic and quality of life impact of acute urinary stone disease in a district general hospital catchment population

Dr Srirangam

East Lancashire Hospitals NHS Trust  

Last checked 7th September 2018

Women, newborn and children’s research

You may need to talk to your doctor or midwife about taking part in the studies listed here.

If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact the women's health research team:

Burnley General Hospital: 01282 803081

Royal Blackburn Hospital: 01254 732650

Short title

Description

Patient group

Local Researcher

Sponsor

Find out more

BIOJUME

Biology of Juvenile Myoclonic Epilepsy 

Children

Dr R Belderbos

Kings College London

Childhood Epilepsy website

CF Start

The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial

Children Dr D Corbett Alder Hey Childrens NHS FT CF START website

EU Patch

EU Patch: The role of glasses wearing in amblyopia treatment

Children

Mrs M Mohan

University of Leicester

UK Clinical Trials Gateway

Prednos 2

Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study.

Children

Dr J Iqbal

University of Birmingham

Prednos 2 study website

RaDaR

National Studies of Rare Kidney Diseases

Children

Dr J Iqbal

Medical Research Council

Rare Renal website

REGAIN Rolandic Epilepsy Genomewide Association International Study
(REGAIN)
Children Dr R Belderbos King’s College London and King’s College Hospital NHS Trust Childhood Epilepsy.org website

UK ITP registry

The UK Paediatric ITP Registry

Children,

Dr V Holme

Royal Manchester Children's Hospital

UK Paediatric ITP Working Party website

ADDRESS-2

An incident and high risk type 1 diabetes research cohort: After Diagnosis Diabetes REsearch Support System-2 (ADDRESS-2)

Children, diabetes

Dr A Del Rio

Imperial College of Science, Technology and Medicine

ADDRESS-2 study website

TrialNet LIFT Study

Long Term investigative Follow-up in TrialNet (LIFT)

Children, diabetes

Dr Ramtoola

University of Bristol

Trialnet study website

Trialnet (pathway to prevention study)

Natural history study of the development of type I diabetes, phase 1, 2 and 3

Children, diabetes

Dr C Gardner

University of Bristol

Trialnet study website

BabyOSCAR

Outcome after Selective early treatment for Closure of patent ductus ARteriosus in pre-term babies

Neonatal

Dr N Soni

University of Oxford

National Perinatal Epidemiology Unit website

  Better care pathways in pregnancies after stillbirth Reproduction Cathie Melvin The University of Manchester UK Clinical Trials Gateway
Big baby trial Induction of labour for predicted macrosomia ‘The Big Baby Trial’ Reproduction Dr S Davies University Hospitals Coventry and Warwickshire NHS Trust UK Clinical Trials Gateway

C-STICH

The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH)

Reproduction

Mrs E Martindale

Birmingham Women's NHS Foundation Trust

Birmingham Clinical Trials Unit Website

GAPP2

A multi-centre randomised controlled trial of the efficacy and mechanism of action of gabapentin for the management of chronic pelvic pain in women

Reproduction

Mrs K Bhatia

University of Edinburgh

Birmingham Clinical Trials Unit website

GEM3

A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy

Reproduction

Dr F Clarke

NHS Lothian

Birmingham Clinical Trials Unit

LATITUDE

An observational study of patient choice and the use of the urethral bulking agent Bulkamid, as a first line treatment for stress urinary incontinence and the effect on a subsequent mid urethral sling

Reproduction

Mr Simon Hill

Central Manchester University Hospitals NHS Foundation Trust

 

MifeMiso A randomised, placebo-controlled trial of mifepristone and misoprostol versus misoprostol alone in the medical management of missed miscarriage Reproduction Mrs K Bhatia University of Birmingham Birmingham Clinical Trials Unit website

MiQuit3 

RCT and meta analysis testing effectiveness and cost-effectiveness of a tailored text message programme (MiQuit) for smoking cessation in pregnancy

Reproduction

Cathie Melvin

University of Nottingham

 

PIP

Pipelle for pregnancy (PIP) studies

Reproduction

Mrs S Nethra

Auckland District Health Board (New Zealand)

 

PREP

Helping Pregnant smokers to quit: A multi-centre RCT of electronic cigarettes vs. nicotine patches (usual care)

Reproduction

Mr M Maher

Queen Mary University of London

 

SERENITY

A phase 2a, randomized, double-blind, placebo-controlled,
parallel-group, proof of concept study to investigate efficacy,
safety, pharmacodynamics and pharmacokinetics of ASP6294 in
the treatment of female subjects with bladder pain
syndrome/interstitial cystitis

Reproduction

Mr S Hill

Astellas Pharma Europe B.V.

UK Clinical Trials Gateway

STOPPIT 2

An open randomised trial of the Arabin pessary to prevent preterm birth in twin pregnancy, with health economics and acceptability

Reproduction

Dr J Nugent

University of Edinburgh

STOPPIT 2 trial website

Last updated 4th December 2018

Finding research studies on the internet

Clinical research studies happening locally and nationally can be found by searching the following databases: