We provide high quality healthcare services primarily to the residents of East Lancashire and Blackburn with Darwen, which have a combined population in the region of 530,000.
The clinical research studies currently available to patients at East Lancashire Hospitals NHS Trust are listed below:
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
Short title
Description
Local researcher
Further information
ASCRIBED
The impact of Acute Systematic inflammation upon cerebrospinal fluid and blood Biomarkers of brain inflammation and injury in Dementia: a study in acute hip fracture patients
Dr A Shannon
PQIP
Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme
Dr M Pollard
PQIP website
Last updated 18th December 2018
For information about any of our cancer studies, please contact the cancer research team on 01254 733299.
Find out more
HORIZONS
HORIZONS: Understanding the impact of cancer diagnosis and treatment on everyday life (breast, gynaecological cancer and non Hodgkin lymphoma)
K Jewers
Horizons study website
IPATential 150 prostate study
A phase III, randomised, double-blind, placebo controlled multi-centre trial testing Ipatasertib plus Abiraterone plus Prednisone/Prednisolone relative to placebo plus abiraterone plus prednisone/prednisolone in adult male patients with asymptomatic or mildly symptomatic, previously untreated, metastatic castrate-resistant prostate cancer
Dr O Parikh
Measures
The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative Neoplasms
Dr Adiyodi
NSCCG
National Study of Colorectal Cancer Genetics
Dr M Wise
Cancer Research UK website
RAIDER
A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder
Rapper
Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy
Dr Charnley
SEARCH
A population based study of genetic predispositions and gene-environment interactions in cancer (ovarian and endometrial)
Dr M Hogg
Stampede
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy
True NTH UK
(post surgery follow-up)
Development and evaluation of a patient-reported instrument to monitor oncological and functional outcomes after radical prostatectomy (prostate)
Mr S Srirangham
UK Clinical Trials Gateway
UKGPC study
UK Genetic Prostate Cancer Study
The Institute of Cancer Research website
The “65” Trial
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension
Dr J Roberts
The REST study
Protective ventilation with veno-venous lung assist in respiratory failure
Dr S Chukkambotla
Last updated 11th February 2019
Patient group
Local Researcher
MYDIABETES
A cross-sectional study to characterise young onset diabetes in two UK ethnic groups
Diabetes
Dr S Ramtoola
My DIABETES study webpage
StartRight
Getting the right classification and treatment from diagnosis of diabetes
ATAM - Developing and validating a therapeutic alliance measure
Aphasia Therapeutic Alliance Measure (ATAM): Development and preliminary psychometric evaluation
Stroke
Catherine Curley
BRAINS
British repository of DNA in stroke: towards the identification of new drug targets
Dr N Goorah
The BRAINS study website
LLIFT
Pilot study to test the clinical efficacy of FlowOx™ home treatment compared to standard care in patients with critical limb ischemia and lower limb ulcers
Blood vessels
Mr Simon Hardy
UK GRIS
Effectiveness of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome
Heart
Prof S Garg
UK Clinical Trials Gateway website
Characterisation of subretinal hyper-reflective material in nAMD
The characterisation of subretinal hyper-reflective material using Heidelberg Optical Coherence Tomography and Heidelberg Multicolour imaging in neovascular age-related macular degeneration
Eyes
Dr Z Al-Moasseb
Stereotactic radiotherapy for wet AMD (STAR)
StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): A randomised, double-masked, sham-controlled, clinical trial comparing low-voltage X-ray irradiation with as needed ranibizumab, to as needed ranibizumab monotherapy
Mrs S Abugreen
EMBARC: European Bronchiectasis Registry
The EMBARC European Bronchiectasis Registry
Lung
Dr I Crossingham
Last checked 18th December 2018
BILAG-2004 VALIDATION
Validation of BILAG2004 index for assessment of disease activity in systemic lupus erythematosus
Musculoskeletal
Prof L Teh
Dupuytren’s Interventions Surgery vs. Collagenase (DISC)
A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients
Dr F Younis
GRASP
GRASP: Getting it Right: Addressing Shoulder Pain. Clinical and cost effectiveness of progressive exercise compared to best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: a 2x2 factorial randomised controlled trial
Dr A Hallett, Helen Thompson
GRASP study website
PREVENT-RA
PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis
PREVeNT RA website
TOXICITY FROM BIOLOGIC THERAPY (BSRBR)
Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis
University of Manchester BSRBR-RA study website
USEFUL
UltraSound Evaluation For mUsculoskeletal Lupus
BADBIR
British Association of Dermatologists Biologic Interventions Register
Skin
Dr Owen
BADBIR study website
B-STOP
A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis
DRAFFT 2
DRAFFT 2: Distal Radius Acute Fracture Fixation Trial - A Randomised Controlled Trial of Manipulation and surgical fixation with K-wires versus Manipulation and Casting in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius
Mr M Srinivasan
University of Oxford website
HIP study
Hartmann’s procedure versus Intersphincteric APE
Mr A Sheikh
PPAC2 - Packing of Perianal Abscess Cavities 2
The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial
Miss J Smith
North West Research Collaborative website
PUrE
The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT Percutaneous nephrolithotomy (PNL), flexible Ureterorenoscopy (FURS) and Extracorporeal lithotripsy (ESWL) for lower pole kidney stones
Mr S Srirangam
PUrE study website
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
You may need to talk to your doctor or midwife about taking part in the studies listed here.
If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact the women's health research team:
Burnley General Hospital: 01282 803081
Royal Blackburn Hospital: 01254 732650
BIOJUME
Biology of Juvenile Myoclonic Epilepsy
Children
Dr R Belderbos
Childhood Epilepsy website
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial
EU Patch
EU Patch: The role of glasses wearing in amblyopia treatment
Mrs M Mohan
Prednos 2
Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study.
Dr J Iqbal
Prednos 2 study website
RaDaR
National Studies of Rare Kidney Diseases
Rare Renal website
UK ITP registry
The UK Paediatric ITP Registry
Children,
Dr V Holme
UK Paediatric ITP Working Party website
TrialNet LIFT Study
Long Term investigative Follow-up in TrialNet (LIFT)
Children, diabetes
Dr Ramtoola
Trialnet study website
Trialnet (pathway to prevention study)
Natural history study of the development of type I diabetes, phase 1, 2 and 3
Dr C Gardner
BabyOSCAR
Outcome after Selective early treatment for Closure of patent ductus ARteriosus in pre-term babies
Neonatal
Dr N Soni
National Perinatal Epidemiology Unit website
C-STICH
The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH)
Reproduction
Mrs E Martindale
Birmingham Clinical Trials Unit Website
GAPP2
A multi-centre randomised controlled trial of the efficacy and mechanism of action of gabapentin for the management of chronic pelvic pain in women
Mrs K Bhatia
Birmingham Clinical Trials Unit website
GEM3
A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy
Dr F Clarke
Birmingham Clinical Trials Unit
PIP
Pipelle for pregnancy (PIP) studies
Mrs S Nethra
PREP
Helping Pregnant smokers to quit: A multi-centre RCT of electronic cigarettes vs. nicotine patches (usual care)
Mr M Maher
STOPPIT 2
An open randomised trial of the Arabin pessary to prevent preterm birth in twin pregnancy, with health economics and acceptability
Dr J Nugent
STOPPIT 2 trial website
Clinical research studies happening locally and nationally can be found by searching the following databases: