Information for patients taking part in research

We're so grateful to all the East Lancashire patients who’ve volunteered to take part in health research. You join over 35,000 participants since 2008, from our hospitals, who contribute to a better understanding of disease and finding new treatments.

Safety is our priority

The safety of patients and hospital staff is our top priority and we are following the Trust guidance for infection control and hospital appointments. This includes minimising footfall on the hospital site, maintaining social distancing and using decontamination procedures.

If you’re taking part in a research study

If you were taking part in a research study at the hospital before the COVID-19 outbreak, the study team will have contacted you to discuss any changes to your follow up appointments, or to your medication and how to collect this from the hospital. As we restart any research that was temporarily paused, the study team will continue to inform you of any changes that may affect you.

If you have any questions or concerns, please don’t hesitate to get in touch with your study team. Their contact details are as follows:

For women’s health research: 01282 803081
For children's research: 01254 732643
For cancer research: 01254 733299
 

To find out more about our research 

If you’d like to find out more about research at East Lancashire Hospitals, please visit the research pages of this website or you can also follow us on twitter @ELHTresearch. The Be Part of Research website also provides more information on research and lists the studies taking place in East Lancashire and nationally throughout the NHS.

You can find out more about our response to the COVID-19 pandemic here.

For further information about these studies please contact the Research Support Office by calling 01254 732756.

Short title

Description

Status

Local Researcher

Sponsor

Find out more

ISARIC ISARIC/WHO Coronavirus Clinical Characterisation Protocol for Severe Emerging Infections Open Dr S Chukkambotla Oxford University Hospitals NHS Trust Study website
REMAP-CAP Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) Open Dr Nick Truman University Medical Center Utrecht Study website
GENOMICC Genetics of Susceptibility and Mortality in
Critical Care
Study
Open Dr M Smith University of Edinburgh and NHS Lothian Health Board Study website

Last updated 17th March 2024.

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Further information

PQIP

Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme

Dr M Pollard

University College London

PQIP website

VITDALIZE Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency
The UK arm of an International Multi-Centre, Placebo-Controlled, Phase III Double-Blind trial
Dr Anton Krige  University of Birmingham University of Birmingham
MOSAICC  Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administered for critically ill patients with acute kidney injury and metabolic acidosis Dr Matthew  Smith University Hospitals of  Derby and Burton NHS Foundation Triust  
IREHAB Remote Rehab after ICU Dr Nick Truman Ulster University https://warwick.ac.uk/fac/sci/med/research/ctu/trials/irehab/

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th March 2024.

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

IBD BioResource

The UK inflammatory bowel disease bioresource: Progressing from genetics to function and clinical translation in Crohn's Disease & Ulcerative Colitis

Crohn's disease

Dr J Collum

Cambridge University Hospital NHS Foundation Trust

IBD BioResource webpage

NAFLD Bioresource The NAFLD BioResource, part of the NIHR BioResource – A Research Study to Characterise Novel Clinical and Genetic Phenotypes, and Understand the Natural History of Non-Alcoholic Fatty Liver Disease (NAFLD) Hepatology Dr Ioannis Gkikas University Hospitals Birmingham NHS Foundation Trust NIHR Bioresource

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th March 2024

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of our cancer studies, please contact the cancer research team on 01254 733299.

Short title

Description

Local researcher

Sponsor

Find out more

PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant
treatment in patients undergoing transoral surgery for Human
papillomavirus (HPV)-positive oropharyngeal cancer
Mr K Panayiotis Velindre University NHS Trust & Cardiff University Cancer Research UK website
PROTECTOR Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal Mr M Willett  Queen Mary University of London PROTECTOR study webpage

UKGPC study

UK Genetic Prostate Cancer Study

Dr O Parikh

The Institute of Cancer Research

The Institute of Cancer Research website

Cancer Research UK website

POETIC-A PreOperative Endocrine Therapy for Individualised Care with Abemaciclib Miss C Yip The Institute of Cancer Research The Institute of Cancer Research website
ICI Genetics Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity Dr Robin Portner University of Birmingham ici-genetics@contacts.bham.ac.uk
ATNEC ATNEC–Axillary management in T1‐3N1M0 breast cancer patients with FNA or core biopsy proven nodal metastases at presentation who convert to node negative after NEoadjuvant Chemotherapy Mr Inder Kumar University Hospitals of Derby and Burton NHS FT  ATNEC
TRACC Tracking mutations in cell free tumour DNA to predict Relapse in Early Colorectal Cancer Dr K Prasad The Royal Marsden NHS Foundation Trust The Royal Marsden NHS Foundation Trust
PETNECK 2 PETNECK 2: PET-CT guided, symptom-based, patient-initiated surveillance versus clinical follow-up in head and neck cancer Leandros Vassiliou
 
University of Birmingham University of Birmingham

VERITAC 2

ARV471 MetBC w 1Prior Line - Multicenter, Randomized, Open-label Phase 3 Trial of ARV-471± GnRH analogue vs Investigator’s Treatment Choice ± GnRH analogue in Patients with Estrogen Receptor Positive, HER2Negative Advanced Breast Cancer Whose Disease Progressed After One Prior Endocrine based Treatment for Advanced disease Dr Martin Hogg Pfizer Inc VERITAC 2

 

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th March 2024

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

 

Short Title

 

Description Patient Group Local Researcher Sponsor Find out more

C-POS Questionnaire

Children's Palliative care Outcome Scale validation Children Dr Vanessa Holme Kings College London https://www.kcl.ac.uk/research/c-pos

ELSA

 

The ELSA Study: EarLy Surveillance for Autoimmune diabetes Children Dr Chris Gardner University of Birmingham https://www.elsadiabetes.nhs.uk/

ENHANCE Study WS3B

 

End of Life Care for Infants, Children and Young People: a mixed methods evaluation of current practice in England and Wales. (Workstream 3 PART B: Prospective evaluation of care at the end of life in babies and children in NICU and PICU) Children Dr Adarsh Bhulani University of York ENHANCE Wsp3

Glycopyrronium Bromide

 

A study to assess utilisation and safety of Glycopyrronium Bromide 1mg/5ml Oral Solution as licensed for symptomatic treatment of severe sialorrhoea in children and adolescents aged 3 years and older with chronic neurological disorders in the UK Children Dr Vanessa Holme DSRU Education and Research Limited Glycopyrronium Bromide

iGBS3

 

Development of a serocorrelate of protection against invasive Group B Streptococcus disease (iGBS) Children Dr A Konstantinidis St Georges iGBS3

Spiromac

 

SPIROmetry to Manage Asthma in Children (SPIROMAC) Children Dr Dennis Corbett University of Aberdeen Spiromac
Dolfin DOLFIN - Developmental Outcomes of Long Term Feed Supplementation in Neonates Children Dr R Seethamraju Newcastle Upon Tyne NHS Trust https://www.npeu.ox.ac.uk/dolfin

 

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th March 2024

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local Researcher

Sponsor

Find out more

iCorMicA International study of Coronary Microvascular Angina (iCorMicA): a randomised, controlled, multicentre trial and registry Cardiovascular Dr Kanarath Balachandran NHS Greater Glasgow and Clyde Healthboard Clinical Trials.gov website
AFAR Atrial Fibrillation  After Resection  Cardiovascular Mr Nick Heywood Sheffield Teaching Hospital AFAR
DNA Lacunar  Genetic risk factors for cerebral small vessal disease Stroke Dr Anand Nair Cambridge University Hospitals University of Cambridge
REDUCE Reducing the impact of diabetic foot ulcers (REDUCE): A effectiveness and cost-effectiveness Randomised Controlled Trial Diabetes G Lomax University Hospitals of Derby & Burton NHS Foundation Trust Clinical Trials.gov website
Huawei Stroke Study (HSS) Evaluation of Huawei Smartwear for Detection of Atrial Fibrillation in a Post-Stroke Population: The Huawei Stroke Study Stroke Mark Delabajan
 
University of Liverpool HSS
RADAR Rapid Assay Diagnostic for Acute Stroke Recognition  Stroke Dr Catherine Curley

Northumbria Healthcare NHS Foundation Trust

https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/radar-trial/
RADIAL Pan-European proof-of-concept study comparing Decentralised Clinical Trial (DCT) and hybrid approaches to conventional clinical trial approaches in patients with Type 2 diabetes mellitus treated with Toujeo® Diabetes Dr Shenaz Ramtoola University Medical Centre Utrecht The Radial Trial
COMMITS Confirming the Mechanism of Motivational Interviewing Therapy after Stroke: a multi-centre randomised controlled trial Stroke Mr Stephen Duberley UCLAN Commits
SAYS (Speech after Stroke recovery) Speech after stroke recovery study: exploring speech recovery over time Stroke Siobhan Neild University of Manchester The Says Study
E-YUKON  Safety and clinical performance of the Yukon Choice PC, Yukon Chrome PC & Yukon Choice Flex Sirolimus Eluting Bioabsorbable Polymer Stents Systems in Routine Clinical Practice: e-Yukon Global Registry Cardiovascular Dr K Balachandran Kings College Hospitals NHS Trust  
ALPHA Long A Prospective Multicenter Single Arm Trial to Assess the Safety and Effectiveness of additional sizes of the BioMatrix AlphaTM (Cobalt Chromium Biolimus A9TM drug-eluting stent) – ALPHA LONG study Cardiovascular Professor Scot Garg Biosensors Europe S.A  
ULTRA Long A Prospective Multi-center Single Arm Trial to Assess the Safety and Effectiveness of Longer Length BioFreedomTM Ultra CoCr Biolimus A9TM Coated Coronary Stents (ULTRA LONG) Cardiovascular Professor Scot Garg Biosensors Europe S.A  

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th March 2024

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

SAVER Sodium Valproate for Epigenetic Reprogramming in the Management of High Risk Oral Epithelial Dysplasia Oral and Dental Health Mr K Panayiotis University of Liverpool https://livrepository.liverpool.ac.uk/3130119/
ASPECT Aspirin after hospitalisation with Pneumonia to prevent cardiovascular Events randomised Controlled Trial Respiratory Dr K Geerthan North Bristol NHS Trust  
TB Dili Reintroduction of anti-tuberculosis therapy following drug-induced liver injury Respiratory Dr Stephen Wilson Nottingham University Hospitals NHS Trust https://www.nctu.ac.uk/studies/current-studies/tb-dili.aspx
STARFISH A randomised controlled trial of STeroid Administration Routes For Idiopathic Sudden sensorineural Hearing loss ENT Dr Surya Narayan University of Birmingham The Starfish Study
TIPAL The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): a randomised placebo-controlled multi-centre clinical trial Respiratory Dr Nadeem Anwar Norfolk and Norwich University Hospitals NHS Foundation Trust The TIPAL Study
IMPROVE Improving life quality in chronic obstructive pulmonary disease (COPD) by increasing uptake and completion of pulmonary rehabilitation with lay health workers: a cluster randomised controlled trial Respiratory Diane Gaiger Kings College London https://improvetrial.co.uk/

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th March 2024

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

         

 

BADBIR

British Association of  Dermatologists Biologic Interventions Register

Skin

Dr Owen

University of Manchester

BADBIR study website

B-STOP

A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis

Skin

Dr Owen

Guy's and St Thomas' NHS Foundation Trust

 

BILAG BILAG Biologic Prospective Cohort Musculoskeletal Prof L S Teh University of Manchester  
Toxicity from biological therapy (BSRBR) Prospective observational study of the long term hazards of biologic therapy in rheumatoid arthritis. Musculoskeletal ProfL S Teh Universuty of Manchester https://www.bsrbr.org/
IMID Bioresource IMID (Immune-Mediated Inflammatory Diseases)BioResource - part of NIHR BioResource Muskoskeletal Prof L S Teh University of Manchester  

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th March 2024

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Find out more

Panraman New biomarker identification of pancreatic cancer to improve diagnosis Mr D Subar Lancaster University  
The Sunflower Study A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones Mr D Subar Leeds Teaching Hospitals NHS Trust CTEU Bristol website
UK-ROX Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. Dr N Truman Intensive Care National Audit & Research Centre ICNARC website
EVIS Early Vasopressors in Sepsis  Dr Nick Truman NHS Greater Glasgow and Clyde Healthboard https://sepsisresearch.org.uk/evis/
WHITE 11 The World Hip Trauma Evaluation Mr Andrew Sloan University of Oford  https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/the-white-study

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th March 2024

You may need to talk to your doctor or midwife about taking part in the studies listed here.

If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact the women's health research team:

Burnley General Hospital: 01282 803081

Royal Blackburn Hospital: Women's health: 01254 732650; Children's research: 01254 732643.

Short Title

Description

Patient Group

Local Researcher

Sponsor

Find out more

ESPRIT2

 

A multi-centre randomised controlled trial to determine the effectiveness of laparoscopic removal of isolatedsuperficial peritoneal endometriosis for the management of chronic pelvic pain in women: ESPriT2 Reproduction Dr Robyn Wittersheim University of Edinburgh https://www.ed.ac.uk/centre-reproductive-health/esprit2

FERN

 

FERN: Intervention or Expectant Management for Early Onset Selective Fetal Growth Restriction in Monochorionic Twin Pregnancy Reproduction Mr Martin Maher University of Liverpool https://www.liverpool.ac.uk/life-course-and-medical-sciences/research/groups/fern-study/

Giant Panda

 

Pregnancy ANtihypertensive Drugs: which Agent is best? Reproduction Dr Sarah Davies University of Birmingham Giant Panda

POISE

 

Hormone therapy for premature ovarian insufficiency: randomised trial and long-term evaluation Reproduction Dr S Nethra University of Nottingham https://poise.ac.uk/home.aspx

REGAL

 

Recurrence of Endometriosis: A randomised controlled trial of clinical and cost-effectiveness of Gonadotrophin Releasing Hormone Analogues with add-back hormone replacement therapy versus repeat Laparoscopic surgery(REGAL trial) Reproduction Dr M Abdel-Aty University of Aberdeen Regal

Stoppit M

 

Infant hypothalamic-pituitary-adrenal axis responses following antenatal corticosteroids and perinatal outcomes: a mechanism of action of health intervention study (STOPPIT-M) Reproduction Dr Justine Nugent University of Edinburgh https://edinburgh-pregnancy-research.ed.ac.uk/current-studies/stoppit3
STOPPIT 3 A randomised placebo-controlled trial of Antenatal Corticosteroids for planned birth in twins Reproduction Dr Justine Nugent University of Edinburgh STOPPIT 3

Tommys National Rainbow Clinic

 

The Tommy's National Rainbow Clinic Study Reproduction Mr Martin Maher Manchester Foundation Trust TOMMYS

Early vs Late Glucose Monitoring

 

An observational nested multicenter cohort study of early versus late monitoring among pregnant women with a history of gestational diabetes Reproduction Sarah Carter Chelsea and Westminster NHS Trust EarlyvsLate

OBS UK

 

Clinical and cost-effectiveness of a maternity quality improvement programme to reduce excess bleeding and need for transfusion after childbirth: the Obstetric Bleeding Study UK (OBS UK) Stepped Wedge Cluster Randomised Trial Reproduction Dr Sarah Loveridge University of Cardiff OBS UK

SNAP 3

 

Open-label randomised controlled trial of enhanced support and nicotine replacement therapy (NRT) offered for preloading, lapse recovery and smoking reduction: impact on smoking in pregnancy Reproduction Mrs Bev Hammond University of Nottingham SNAP 3

 

* Study not open to new participants at ELHT (Temporary pause)

Last updated 17th January 2024

Clinical research studies happening locally and nationally can be found by searching the following databases: