Information for patients taking part in research
We're so grateful to all the East Lancashire patients who’ve volunteered to take part in health research. You join over 20,000 participants from our hospitals, who contribute to a better understanding of disease and finding new treatments.
Safety is our priority
The safety of patients and hospital staff is our top priority and we are following the Trust guidance for infection control and hospital appointments. This includes minimising footfall on the hospital site, maintaining social distancing and using decontamination procedures.
If you’re taking part in a research study
If you were taking part in a research study at the hospital before the COVID-19 outbreak, the study team will have contacted you to discuss any changes to your follow up appointments, or to your medication and how to collect this from the hospital. As we restart any research that was temporarily paused, the study team will continue to inform you of any changes that may affect you.
If you have any questions or concerns, please don’t hesitate to get in touch with your study team. Their contact details are as follows:
For women’s health research: 01282 803081
For children's research: 01254 732643
For cancer research: 01254 733299
For all other research: 01254 732756
To find out more about our research
If you’d like to find out more about research at East Lancashire Hospitals, please visit the research pages of this website or you can also follow us on twitter @ELHTresearch. The Be Part of Research website also provides more information on research and lists the studies taking place in East Lancashire and nationally throughout the NHS.
You can find out more about our response to the COVID-19 pandemic here.
COVID-19
For further information about these studies please contact the Research Support Office by calling 01254 732756.
|
Short title |
Description |
Status |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
| ISARIC | ISARIC/WHO Coronavirus Clinical Characterisation Protocol for Severe Emerging Infections | Open | Dr S Chukkambotla | Oxford University Hospitals NHS Trust | Study website |
| RECOVERY | Randomised Evaluation of COVID-19 Therapy | Open | Dr Nick Truman | University of Oxford | Study website |
| REMAP-CAP | Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) | Open | Dr Nick Truman | University Medical Center Utrecht | Study website |
| GENOMICC | Genetics of Susceptibility and Mortality in Critical Care Study |
Open | Dr M Smith | University of Edinburgh and NHS Lothian Health Board | Study website |
| SINEPOST study | SARS-CoV-2 Infection in NEonates or in Pregnancy: Outcomes at EighTeen months | Open | Mrs B Hammond | University of Bristol | Study website |
* Study not open to new participants at ELHT (Temporary pause due to COVID 19)
Last updated 20th January 2022
Anaesthetics, pain and critical care
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
| ALLEGRO | A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery | Prof A Krige | University of Edinburgh and NHS Lothian | ALLEGRO study website |
|
PQIP |
Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme |
Dr M Pollard |
University College London | |
| VITDALIZE | Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency The UK arm of an International Multi-Centre, Placebo-Controlled, Phase III Double-Blind trial |
Dr Anton Krige | University of Birmingham | University of Birmingham |
| MOSAICC | Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administered for critically ill patients with acute kidney injury and metabolic acidosis | Dr Matthew Smith | University Hospitals of Derby and Burton NHS Foundation Triust |
* Study not open to new participants at ELHT (Temporary pause)
Last updated 29th March 2022
Digestive tract and liver
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
IBD BioResource |
The UK inflammatory bowel disease bioresource: Progressing from genetics to function and clinical translation in Crohn's Disease & Ulcerative Colitis |
Crohn's disease |
Dr J Collum |
Cambridge University Hospital NHS Foundation Trust | |
| Phase 2 dose-finding UC study* | A 54-Week Treatment, Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo and Active-Controlled, Parallel-Group Phase 2 Study to Assess the Efficacy and Safety of Brazikumab in Participants with Moderately to Severely Active Ulcerative Colitis | Ulcerative Colitis | Dr J Collum | Allergan Limited |
* Study not open to new participants at ELHT (Temporary pause)
Last updated 01st September 2022
Cancer, including cancers of the blood
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of our cancer studies, please contact the cancer research team on 01254 733299.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|
|---|---|---|---|---|---|
| ACE | A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) | Dr Parikh | University Hospitals Bristol NHS Trust | ||
| CLOCS* |
Cancer Loyalty Card Study This study is recruiting women with ovarian cancer and healthy female volunteers. For further details please visit the CLOCS study website |
Dr Badea | Imperial College London | CLOCS study webpage | |
| PATHOS | A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer |
Mr K Panayiotis | Velindre University NHS Trust & Cardiff University | Cancer Research UK website | |
| PROTECTOR | Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal | Mr M Willett | Queen Mary University of London | PROTECTOR study webpage | |
|
Rapper* |
Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy |
Dr Charnley |
University of Manchester | NHS choices | |
|
Stampede* |
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy |
Dr O Parikh |
MRC Clinical Trials Unit at University College London | ||
|
UKGPC study |
UK Genetic Prostate Cancer Study |
Dr O Parikh |
The Institute of Cancer Research | ||
| POETIC-A | PreOperative Endocrine Therapy for Individualised Care with Abemaciclib | Miss C Yip | The Institute of Cancer Research | The Institute of Cancer Research website | |
| ICI Genetics | Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity | Dr Hassan Shikhrakab | University of Birmingham | If you wish to take part in the study or know more about what it involves, please contact our research team using our email address ici-genetics@contacts.bham.ac.uk | |
| EUCHARIS |
|
Dr Martin Hogg | Pfizer | Eucharis Trial | |
| TINIVO 2 | A Phase 3, Randomized, Controlled, Multicenter, Open-label Study to Compare Tivozanib in Combination with Nivolumab to Tivozanib Monotherapy in Subjects with Renal Cell Carcinoma Who Have Progressed Following One or Two Lines of Therapy Where One Line has an Immune Checkpoint Inhibitor | Dr Omi Parikh | Aveo Pharmaceuticals | Aveo Pharmaceuticals_TINIVO 2 | |
| Contact-02 | A Phase 3, Randomized, Open-Label, Controlled Study of Cabozantinib (XL184) in Combination with Atezolizumab vs Second Novel Hormonal Therapy (NHT) in Subjects with High-Risk, Metastatic Castration-Resistant Prostate Cancer | Dr Omi Parikh | Exelixis Inc | Exelixis website | |
| PanCanCGM | Continuous glucose monitoring in patients with pancreatic cancer | Mr D Subar | Lancaster University |
* Study not open to new participants at ELHT (Temporary pause)
Last updated 18th August 2022
Child and adolescent mental health
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
| Glycopy Bromide | A study to assess utilisation and safety of Glycopyrronium Bromide 1mg/5ml Oral Solution as licensed for symptomatic treatment of severe sialorrhoea in children and adolescents aged 3 years and older with chronic neurological disorders in the UK | Dr Vanessa Holme | DSRU Education and Research Limited | |
| CRAFFT | Children’s Radius - Acute Fracture Fixation Trial: A multi-centre prospective randomised non-inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children | Dr Fizan Younis | University of Oxford | https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/crafft |
|
* Study not open to new participants at ELHT (Temporary pause) Last updated: 11th January 2022 |
||||
Diabetes, stroke, heart and blood vessel disease
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
| Address-2 | An incident and high risk type 1 diabetes research cohort – After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2) |
Diabetes | Dr Del Rio | Imperial College London | ADDRESS-2 study website |
|
BRAINS |
British repository of DNA in stroke: towards the identification of new drug targets |
Stroke |
Dr N Goorah |
Imperial College Healthcare NHS Trust | |
| CONVINCE | COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke | Stroke | Dr A Singh | University College Dublin | https://www.uclan.ac.uk/research/activity/convince |
| Orion-4 | A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease |
Heart and blood vessel | Dr Ramtoola | University of Oxford | https://www.ctsu.ox.ac.uk/research/orion-4 |
| RECREATE | A multicentre cluster randomised controlled trial evaluating the clinical and cost-effectiveness of an intervention to reduce sedentary behaviour in stroke survivors incorporating an internal pilot phase and embedded process evaluation | Stroke | Samantha Hancock | Bradford Teaching Hospitals NHS Foundation Trust | Bradford Teaching Hosptals NHS Foundation Trust website |
| L-HARP | Liverpool Heart and Brain Project | Stroke | Sheeba Philip | University of Liverpool | https://www.lhch.nhs.uk/research/clinical-trials-unit/contributing-to-clinical-research/ |
|
EVAREST |
The use of Blood Biomarkers, including extracellular vesicles to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram | Cardiovascular | Sanjay Banypersad | University of Oxford | https://www.rdm.ox.ac.uk/about/our-clinical-facilities-and-mrc-units/cardiovascular-clinical-research-facility/evarest-1/about-evarest |
| iCorMicA | International study of Coronary Microvascular Angina (iCorMicA): a randomised, controlled, multicentre trial and registry | Cardiovascular | Dr Balachandran | NHS Greater Glasgow and Clyde Healthboard | Clinical Trials.gov website |
| OPTIMAS | OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial. | Stroke | Dr Singh | University College London | https://optimas.org.uk/ |
| AFAR | Atrial Fibrillation After Resection | Cardiovascular | Mr Heywood | Sheffield Teaching Hospital | AFAR |
| DNA Lacunar | Genetic risk factors for cerebral small vessal disease | Stroke | Dr Anand Nair | Cambridge University Hospitals | University of Cambridge |
* Study not open to new participants at ELHT (Temporary pause)
Last updated 27th September 2022
Ear, nose and throat, infectious diseases, eyes and lungs
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|
|---|---|---|---|---|---|---|
| BICS* | A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease | Lung | Dr I Crossingham | University of Aberdeen/NHS Grampian | BICS study website | |
| SAVER | Sodium Valproate for Epigenetic Reprogramming in the Management of High Risk Oral Epithelial Dysplasia | Oral and Dental Health | Mr K Panayiotis | University of Liverpool | https://livrepository.liverpool.ac.uk/3130119/ | |
| BESRA |
|
Opthalmology | Miss Salwa Abugreen | Novartis | https://www.novartis.com/clinicaltrials | |
| PHIND | Clinical evaluation of a POC assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome | Respiratory | Dr Waqar-Uddin | Queen's University Belfast | ||
| UNICORNS | UNICORNS: Uveitis in childhood | Opthalmology | Mrs M Mohan | UCL Great Ormond Street Intitute of Child Health (ICH) |
* Study not open to new participants at ELHT (Temporary pause)
Last updated 05th September 2022
Skin, muscle, bone and connective tissue disorders
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
|
|||||
|
BADBIR |
British Association of Dermatologists Biologic Interventions Register |
Skin |
Dr Owen |
University of Manchester | |
|
B-STOP |
A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis |
Skin |
Dr Owen |
Guy's and St Thomas' NHS Foundation Trust |
|
| PREVENT RA | PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis | Muskoskeletal | Prof L S Teh | University of Manchester | Prevent RA |
| BILAG | BILAG Biologic Prospective Cohort | Musculoskeletal | Prof L S Teh | University of Manchester | |
| Toxicity from biological therapy (BSRBR) | Prospective observational study of the long term hazards of biologic therapy in rheumatoid arthritis. | Musculoskeletal | Prof Symmons | Universuty of Manchester | https://www.bsrbr.org/ |
| IMID Bioresource | IMID (Immune-Mediated Inflammatory Diseases)BioResource - part of NIHR BioResource | Muskoskeletal | Prof L S Teh | University of Manchester |
* Study not open to new participants at ELHT (Temporary pause)
Last updated 26th July 2022
Surgery, injuries and emergencies
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
| Panraman | New biomarker identification of pancreatic cancer to improve diagnosis | Mr D Subar | Lancaster University | |
| The Sunflower Study | A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones | Mr D Subar | Leeds Teaching Hospitals NHS Trust | CTEU Bristol website |
| Recurrence after Whipple's (RAW) | An international multi-centre retrospective cohort study investigating factors affecting cancer recurrence following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, ampullary adenocarcinoma and distal bile duct cholangiocarcinoma | Miss A Kausar | University of Southampton NHS Trust | National Institute for Health Research |
| UK-ROX | Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. | Dr N Truman | Intensive Care National Audit & Research Centre | ICNARC website |
| SPECS | A mechanistic trial comparing standard care versus prehabilitation in patients undergoing elective HPB and colorectal cancer surgery: a feasibility study | Dr Joel Lambert | East Lancashire Hospitals NHS Trust |
* Study not open to new participants at ELHT (Temporary pause)
Last updated 13th May 2022
Women, newborn and children’s research
You may need to talk to your doctor or midwife about taking part in the studies listed here.
If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact the women's health research team:
Burnley General Hospital: 01282 803081
Royal Blackburn Hospital: Women's health: 01254 732650; Children's research: 01254 732643.
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
||
|---|---|---|---|---|---|---|---|
|
BIOJUME |
Biology of Juvenile Myoclonic Epilepsy |
Children |
Dr R Belderbos |
Kings College London | |||
| CF Start |
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial |
Children | Dr D Corbett | Alder Hey Childrens NHS FT | CF START website | ||
| REGAIN | Rolandic Epilepsy Genomewide Association International Study (REGAIN) |
Children | Dr R Belderbos | King’s College London and King’s College Hospital NHS Trust | Childhood Epilepsy.org website | ||
|
UK ITP registry |
The UK Paediatric ITP Registry |
Children, |
Dr V Holme |
Royal Manchester Children's Hospital | |||
| Address-2 | An incident and high risk type 1 diabetes research cohort – After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2) |
Children, diabetes | Dr Del Rio | Imperial College London | ADDRESS-2 website | ||
| Big baby trial | Induction of labour for predicted macrosomia ‘The Big Baby Trial’ | Reproduction | Dr S Davies | University Hospitals Coventry and Warwickshire NHS Trust | UK Clinical Trials Gateway | ||
| CRAFT | Cerclage after full dilatation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies | Reproduction | F Clarke | King's College London | |||
| LOCI | Letrozole Or Clomifene for Ovulation Induction | Reproduction | Ms Nethra | University of Birmingham | |||
| The Parrot-2 Trial | Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia | Reproduction | Mr Maher | King's College London | Parrot-2 website | ||
| Tommys Rainbow | The Tommy's National Rainbow Clinic Study | Children | Mr Maher | The University of Manchester | https://www.tommys.org/ | ||
|
ESPRIT 2
|
A multi-centre randomised controlled trial to determine the effectiveness of laparoscopic removal of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women: ESPriT2 |
Reproduction | Dr Wittersheim | The University of Edinburgh | https://www.ed.ac.uk/centre-reproductive-health/exppect-endometriosis/research/esprit | ||
| Giant Panda | Pregnancy ANtihypertensive Drugs: which Agent is best? | Reproduction | Dr Davies | University of Birmingham | https://www.birmingham.ac.uk/research/bctu/trials/womens/giantpanda/index.aspx | ||
| FACT4CHILD | Folic Acid Clinical Trial: Follow up of children |
Children |
Heather Collier | Ottawa Hospital, Canada | https://clinicaltrials.gov/ct2/show/NCT03269110 | ||
| PURSUIT | Proper Understanding of Recurrent Stress Urinary Incontinence Treatment in Women: A Randomised Controlled Trial of Endoscopic and Surgical Treatment | Womens | Mr S Hill | North Bristol NHS Trust | Pursuit North Bristol NHS Trust | ||
| REGAL Study | Recurrence of Endometriosis: A randomised controlled trial of clinical and cost-effectiveness of Gonadotrophin Releasing Hormone Analogues with add-back hormone replacement therapy versus repeat Laparoscopic surgery(REGAL trial) | Reproduction | Mr Aty | University of Aberdeen | University of Aberdeen | ||
| GBS3 |
|
Reproduction | Dr Justine Nugent | University of Nottingham | https://www.gbs3trial.ac.uk/home.aspx | ||
| iGBS3 | Development of a serocorrelate of protection against invasive Group B Streptococcus disease (iGBS) | Children | Dr Konstantindis | St Georges University of London | https://www.gbsatstgeorges.co.uk/igbs3 | ||
| OHANA | A Placebo-controlled RCT Volixibat intrahepatic cholestasis pregnancy | Reproduction | Mr Yen Eit Liew | Mirum Pharmaceuticals | |||
| COPE | The Carboprost or Oxytocin Postpartum haemorrhage Effectiveness Study | Reproduction | Mr Yen Eit Liew | University of Liverpool | https://copestudy.uk/ | ||
| ABA-Feed | The effectiveness and cost-effectiveness of Assets-based feeding help Before and After birth. | Reproduction | Bev Hammond | University of Birmingham |
|
||
| HARMONIE | A Phase IIIb randomized open label study of nirsevimab (versus no intervention) in preventing hospitalizations due to respiratory syncytial virus in infants | Children | Dr Konstantindis
|
Sanofi | Harmonie Trial Information | ||
| FERN | Intervention or expectant management of early onset selective fetal growth restriction in Monochorionic Twim Pregnancy | Reproduction | Mr Martin Maher | University of Liverpool | The Fern Study UoL |
* Study not open to new participants at ELHT (Temporary pause)
Last updated 27th September 2022
Finding research studies on the internet
Clinical research studies happening locally and nationally can be found by searching the following databases:
- Be part of research
- Join dementia research
- Research for the future (for patients with diabetes, heart, lung and kidney disease)
