Information for patients taking part in research
We're so grateful to all the East Lancashire patients who’ve volunteered to take part in health research. You join over 20,000 participants from our hospitals, who contribute to a better understanding of disease and finding new treatments.
Safety is our priority
The safety of patients and hospital staff is our top priority and we are following the Trust guidance for infection control and hospital appointments. This includes minimising footfall on the hospital site, maintaining social distancing and using decontamination procedures.
If you’re taking part in a research study
If you were taking part in a research study at the hospital before the COVID-19 outbreak, the study team will have contacted you to discuss any changes to your follow up appointments, or to your medication and how to collect this from the hospital. As we restart any research that was temporarily paused, the study team will continue to inform you of any changes that may affect you.
If you have any questions or concerns, please don’t hesitate to get in touch with your study team. Their contact details are as follows:
For women’s health research: 01282 803081
For children's research: 01254 732643
For cancer research: 01254 733299
For all other research: 01254 732756
To find out more about our research
If you’d like to find out more about research at East Lancashire Hospitals, please visit the research pages of this website or you can also follow us on twitter @ELHTresearch. The Be Part of Research website also provides more information on research and lists the studies taking place in East Lancashire and nationally throughout the NHS.
You can find out more about our response to the COVID-19 pandemic here.
COVID-19
For further information about these studies please contact the Research Support Office by calling 01254 732756.
|
Short title |
Description |
Status |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
| ISARIC | ISARIC/WHO Coronavirus Clinical Characterisation Protocol for Severe Emerging Infections | Open | Dr S Chukkambotla | Oxford University Hospitals NHS Trust | Study website |
| UKOSS | Pandemic Influenza in Pregnancy | Open | Ms S Loveridge | University of Oxford | Study website |
| RECOVERY | Randomised Evaluation of COVID-19 Therapy | Open | Dr S Chukkambotla | University of Oxford | Study website |
| REMAP-CAP | Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) | Open | Dr S Chukkambotla | University Medical Center Utrecht | Study website |
| GENOMICC | Genetics of Susceptibility and Mortality in Critical Care Study |
Open | Dr M Smith | University of Edinburgh and NHS Lothian Health Board | Study website |
| Pan-Covid | Pregnancy And Neonatal outcomes for women with Covid-19 | Open | Mrs B Hammond | Imperial College London | Study website |
| PIMCO | The psychological impact of surviving an intensive care admission due to coronavirus disease 2019 (COVID-19) on patients in the United Kingdom | Open | Dr N Truman | Liverpool University Hospitals | Study website |
| SINEPOST study | SARS-CoV-2 Infection in NEonates or in Pregnancy: Outcomes at EighTeen months | Open | Mrs B Hammond | University of Bristol | Study website |
Last updated 02 December 2021
Anaesthetics, pain and critical care
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
| ALLEGRO | A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery | Prof A Krige | University of Edinburgh and NHS Lothian | ALLEGRO study website |
| CASAP | Children's Acute Surgical Abdomen Programme | Dr I Clegg | University College London | |
| EFFORT | The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial | Dr S Clarke | Queen's University at Kingston | |
|
PQIP |
Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme |
Dr M Pollard |
University College London | |
| VITDALIZE | Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency The UK arm of an International Multi-Centre, Placebo-Controlled, Phase III Double-Blind trial |
Dr Anton Krige | University of Birmingham | University of Birmingham |
* Study suspended
Last updated 05th October 2021
Child and adolescent mental health
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
| Glycopy Bromide | A study to assess utilisation and safety of Glycopyrronium Bromide 1mg/5ml Oral Solution as licensed for symptomatic treatment of severe sialorrhoea in children and adolescents aged 3 years and older with chronic neurological disorders in the UK | Dr Vanessa Holme | DSRU Education and Research Limited | |
| CRAFFT | Children’s Radius - Acute Fracture Fixation Trial: A multi-centre prospective randomised non-inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children | Dr Fizan Younis | University of Oxford | https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/crafft |
Cancer, including cancers of the blood
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of our cancer studies, please contact the cancer research team on 01254 733299.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
| ACE | A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) | Dr Parikh | University Hospitals Bristol NHS Trust | |
| ACELARATE* | A Phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with Gemcitabine in patient with metastatic pancreatic carcinoma. |
Dr Ferreira | The Clatterbridge Cancer Centre NHS Foundation Trust | |
| BC-Predict | Impact & acceptability of 10 year risk at breast cancer screening v1 | Mr R Dobrashian | Manchester University NHS Foundation Trust | Cancer Research UK website |
| CLOCS |
Cancer Loyalty Card Study This study is recruiting women with ovarian cancer and healthy female volunteers. For further details please visit the CLOCS study website |
Dr Badea | Imperial College London | CLOCS study webpage |
| MAGNITUDE | Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Subjects with Metastatic Prostate Cancer | Dr O Parikh | Janssen | |
| MOSES | Evaluation of the role of tongue base MucOsectomy and Step sErial Sectioning in the management of the unknown primary squamous cell cancer in the head and neck | Miss N Ghazali | The Royal Marsden NHS Foundation Trust | Be Part of Research website |
| PATHOS | A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer |
Miss N Ghazali | Velindre University NHS Trust & Cardiff University | Cancer Research UK website |
| Prevalence | Biomarker Study to Determine Frequency of DNA-repair Defects in Men with Metastatic Prostate Cancer (Prevalence) | Dr O Parikh | Janssen | |
| PRIMETIME | Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers: Breast cancer | Dr M Hogg | Institute of Cancer Research | Cancer Research UK website |
| PROTECTOR | Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal | Mr M Willett | Queen Mary University of London | PROTECTOR study webpage |
| Q-ABC | Quality of life After Bladder Cancer (Q-ABC): A comparison of patient related outcomes following radical surgery and radiotherapy | Dr O Parikh | Brighton and Sussex University Hospitals NHS Trust | SHORE-C website |
|
Rapper* |
Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy |
Dr Charnley |
University of Manchester | NHS choices |
|
Stampede* |
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy |
Dr O Parikh |
MRC Clinical Trials Unit at University College London | |
|
UKGPC study |
UK Genetic Prostate Cancer Study |
Dr O Parikh |
The Institute of Cancer Research | |
| CPET & Whipples | Clinical effectiveness of CPET in predicting outcomes of Whipple | Miss A Sultana | East Lancashire Hospitals NHS Trust | |
| EFC15935 Ameera-5 | A randomized, multicenter, double-blind phase 3 study of SAR439859 plus palbociclib versus letrozole plus palbociclib for the treatment of patients with ER (+), HER2 (-) breast cancer who have not received any prior systemic anti-cancer treatment for advanced disease | Dr M Hogg | Sanofi-Aventis | Clinical trials website |
* Study suspended
Last updated 03rd December 2021
Diabetes, stroke, heart and blood vessel disease
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
| Address-2 | An incident and high risk type 1 diabetes research cohort – After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2) |
Diabetes | Dr Del Rio | Imperial College London | ADDRESS-2 study website |
| CODIFI2 | Randomised controlled trial of swab versus tissue sampling for infected diabetic foot ulcers, and comparison of culture versus molecular processing techniques | Diabetes | Ms J Lomax | University of Leeds | |
| DROPLET | Defining The Rate Of Progression Of Late Onset Type 1 Diabetes | Diabetes | Dr S Ramtoola | Royal Devon and Exeter NHS Foundation Trust | |
|
MYDIABETES |
MODY in young-onset diabetes in different ethnicities |
Diabetes |
Dr S Ramtoola |
Imperial College of Science, Technology and Medicine | |
|
BRAINS* |
British repository of DNA in stroke: towards the identification of new drug targets |
Stroke |
Dr N Goorah |
Imperial College Healthcare NHS Trust | |
| CONVINCE* | COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke | Stroke | Dr A Singh | University College Dublin | |
| Orion-4 | A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease |
Heart and blood vessel | Dr Ramtoola | University of Oxford | |
| Developing a model of post stroke body image perceptions | Stroke | Samantha Hancock | University of Central Lancashire | ||
| RECREATE | A multicentre cluster randomised controlled trial evaluating the clinical and cost-effectiveness of an intervention to reduce sedentary behaviour in stroke survivors incorporating an internal pilot phase and embedded process evaluation | Stroke | Samantha Hancock | Bradford Teaching Hospitals NHS Foundation Trust | Bradford Teaching Hosptals NHS Foundation Trust website |
| L-HARP | Liverpool Heart and Brain Project | Stroke | Sheeba Philip | University of Liverpool | https://www.lhch.nhs.uk/research/clinical-trials-unit/contributing-to-clinical-research/ |
* Study suspended
Last updated 19th November 2021
Digestive tract and liver
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
IBD BioResource |
The UK inflammatory bowel disease bioresource: Progressing from genetics to function and clinical translation in Crohn's Disease & Ulcerative Colitis |
Crohn's disease |
Dr J Collum |
Cambridge University Hospital NHS Foundation Trust | |
| STATIC* | STATIC – STopping Aminosalicylate Therapy in Inactive Crohn’s Disease (STATIC) Study: A Randomized, Open-label, Non-inferiority Trial | Crohn's disease | Dr J Collum | Robarts Clinical Trials Inc. | British Society of Gastroenterology website |
| Phase 2 dose-finding UC study* | A 54-Week Treatment, Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo and Active-Controlled, Parallel-Group Phase 2 Study to Assess the Efficacy and Safety of Brazikumab in Participants with Moderately to Severely Active Ulcerative Colitis | Ulcerative Colitis | Dr J Collum | Allergan Limited |
* Study suspended
Last updated 9th November 2020
Ear, nose and throat, infectious diseases, eyes and lungs
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|
|---|---|---|---|---|---|---|
| BICS* | A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease | Lung | Dr I Crossingham | University of Aberdeen/NHS Grampian | BICS study website | |
|
EMBARC: European Bronchiectasis Registry* |
The EMBARC European Bronchiectasis Registry |
Lung |
Dr I Crossingham |
NHS Tayside | ||
| POPT | Assessing Post-Operative bleeding, pain and return to work following Tonsillectomy | ENT | Mr Elliot Heward | Wrightington, Wigan and Leigh NHS Foundation Trust | ||
| GTScope | GTSCOPE - A study of disease progression in patients with Dry-AMD | Eye | Ms Salwa Abugreen | Gyroscope Therapeutics Ltd | ||
| SAVER | Sodium Valproate for Epigenetic Reprogramming in the Management of High Risk Oral Epithelial Dysplasia | Oral and Dental Health | Miss Naseem Ghazali | University of Liverpool | https://livrepository.liverpool.ac.uk/3130119/ | |
| BESRA |
|
Opthalmology | Miss Salwa Abugreen | Novartis | https://www.novartis.com/clinicaltrials |
* Study suspended
Last updated 02nd November 2021
Skin, muscle, bone and connective tissue disorders
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
|
|||||
| UKIVAS* | Development of a Pan UK Vasculitis Cohort to Analyse Variations in Disease Susceptibility and Outcomes | Musculoskeletal | Prof L Teh | University of Oxford | |
|
BADBIR |
British Association of Dermatologists Biologic Interventions Register |
Skin |
Dr Owen |
University of Manchester | |
|
B-STOP |
A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis |
Skin |
Dr Owen |
Guy's and St Thomas' NHS Foundation Trust |
|
Study suspended
Last updated 05 October 2021
Surgery, injuries and emergencies
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|
|---|---|---|---|---|---|
| ARTISAN* | Acute Rehabilitation following Traumatic anterior shoulder dISlocAtioN (ARTISAN) - A Multi Centre RCT | Mr S Hadi/Rachel Dean | University of Warwick and University Hospitals Coventry & Warwickshire NHS Trust | ARTISAN study webpage | |
| MURALS Study | Comparing the musculoskeletal demands of surgeons performing Robotic-assisted Laparoscopic surgery and standard laparoscopic surgery | Mr D Subar | Lancaster University | ||
| Panraman | New biomarker identification of pancreatic cancer to improve diagnosis | Mr D Subar | Lancaster University | ||
| The Sunflower Study | A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones | Mr D Subar | Leeds Teaching Hospitals NHS Trust | CTEU Bristol website | |
| SUNRISE | Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy Surgery |
Mr L Jones | University of Birmingham | Birmingham Clinical Trials Unit website | |
| The use of Locum Doctors in the NHS | The use of locum doctors in the NHS: understanding and improving the safety and quality of care | Suzanne Gawne | University of Manchester | University of Manchester | |
| Recurrance after Whipple's (RAW) | An international multi-centre retrospective cohort study investigating factors affecting cancer recurrence following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, ampullary adenocarcinoma and distal bile duct cholangiocarcinoma | Miss A Kausar | University of Southampton NHS Trust | National Institute for Health Research | |
| FAMOUS C19 | The impact of COVID-19 pandemic on the assessment, management and outcomes for patients with common upper Limb fractures in the UK: a multi-centre observational cohort study. [FAMOUS-C19 (Fracture Assessment, Management and Outcomes in Upper limb Study during Covid-19) | Mr S Hadi |
|
||
| UK-ROX | Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. | Dr N Truman | Intensive Care National Audit & Research Centre | ICNARC website | |
| SPECS | A mechanistic trial comparing standard care versus prehabilitation in patients undergoing elective HPB and colorectal cancer surgery: a feasibility study | Dr Joel Lambert | East Lancashire Hospitals NHS Trust |
* Study suspended
Last updated 05th October 2021
Women, newborn and children’s research
You may need to talk to your doctor or midwife about taking part in the studies listed here.
If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact the women's health research team:
Burnley General Hospital: 01282 803081
Royal Blackburn Hospital: Women's health: 01254 732650; Children's research: 01254 732643.
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
BIOJUME |
Biology of Juvenile Myoclonic Epilepsy |
Children |
Dr R Belderbos |
Kings College London | |
| CASAP | Children's Acute Surgical Abdomen Programme | Children | Dr I Clegg | University College London | |
| CF Start |
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial |
Children | Dr D Corbett | Alder Hey Childrens NHS FT | CF START website |
|
RaDaR* |
National Studies of Rare Kidney Diseases |
Children |
Dr J Iqbal |
Medical Research Council | |
| REGAIN | Rolandic Epilepsy Genomewide Association International Study (REGAIN) |
Children | Dr R Belderbos | King’s College London and King’s College Hospital NHS Trust | Childhood Epilepsy.org website |
| USTEKID | Ustekinumab in adolescents with recent-onset type 1 diabetes | Children | Dr Gardner | Cardiff University | |
|
UK ITP registry |
The UK Paediatric ITP Registry |
Children, |
Dr V Holme |
Royal Manchester Children's Hospital | |
| Address-2 | An incident and high risk type 1 diabetes research cohort – After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2) |
Children, diabetes | Dr Del Rio | Imperial College London | ADDRESS-2 website |
| Big baby trial | Induction of labour for predicted macrosomia ‘The Big Baby Trial’ | Reproduction | Dr S Davies | University Hospitals Coventry and Warwickshire NHS Trust | UK Clinical Trials Gateway |
| CERM | Chronic Endometritis and Recurrent Miscarriage - The CERM trial | Reproduction | F Clarke | University Hospitals Coventry and Warwickshire NHS Trust | Warwick Clinical Trials Unit website |
| CRAFT | Cerclage after full dilatation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies | Reproduction | F Clarke | King's College London | |
| C-Stich2 | Cervical Cerclage to Prevent Miscarriage and Preterm Birth - a Randomised Controlled Trial | Reproduction | Mr Yen Eit Liew | Birmingham Women's and Children's NHS Foundation Trust | Birmingham Clinical Trials Unit |
| FROSTTIE | A randomised controlled trial of FRenotomy and breastfeeding support Or breastfeeding Support without frenotomy to investigate continuation of breastfeeding for babies with Tongue-TIE | Reproduction | B Hammond | University of Oxford | FROSTTIE study webpage |
| LOCI | Letrozole Or Clomifene for Ovulation Induction | Reproduction | Ms Nethra | University of Birmingham | |
| Born into care | Born into care: towards inclusive guidlines when the state intervenes at birth | Neonatel | Catherine Walton | Lancaster University | |
| The Parrot-2 Trial | Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia | Reproduction | Mr Maher | King's College London | Parrot-2 website |
| Tommys Rainbow | The Tommy's National Rainbow Clinic Study | Children | Mr Maher | The University of Manchester | https://www.tommys.org/ |
|
ESPRIT 2
|
A multi-centre randomised controlled trial to determine the effectiveness of laparoscopic removal of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women: ESPriT2 |
Reproduction | Mr Aty | The University of Edinburgh | https://www.ed.ac.uk/centre-reproductive-health/exppect-endometriosis/research/esprit |
| AZTEC | A randomised, placebo controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants | Children | Dr Sur | Cardiff University | Cardiff Univeristy website |
| Giant Panda | Pregnancy ANtihypertensive Drugs: which Agent is best? | Reproduction | Dr Davies | University of Birmingham | https://www.birmingham.ac.uk/research/bctu/trials/womens/giantpanda/index.aspx |
| FACT4CHILD | Folic Acid Clinical Trial: Follow up of children |
Children |
Heather Collier | Ottawa Hospital, Canada | https://clinicaltrials.gov/ct2/show/NCT03269110 |
| C-POS | Children’s Palliative Outcome Scale (C-POS) – cognitive interview study to determine comprehensibility, comprehensiveness and feasibility. | Children | Dr Holmes | King's College London | King's College London |
* Study suspended
Last updated 1st December 2021
Finding research studies on the internet
Clinical research studies happening locally and nationally can be found by searching the following databases:
- Be part of research
- Join dementia research
- Research for the future (for patients with diabetes, heart, lung and kidney disease)
