COVID-19 research at ELHT
Health research is vital during the COVID-19 pandemic.
At East Lancashire Hospitals NHS Trust (ELHT) we are part of the national research effort to prevent, diagnose and treat COVID-19. The research is helping us to learn more about the illness, which people are most at risk, and what treatments benefit those affected. East Lancashire patients and our clinical and research staff are playing their part by supporting national, high-priority research studies within our hospitals.
For an up to date summary of the COVID-19 research studies available at ELHT, please check the list below:
Research into other conditions
We're so grateful to all the East Lancashire patients who’ve volunteered to take part in health research. You join over 20,000 participants from our hospitals, who contribute to a better understanding of disease and finding new treatments.
In accordance with guidelines from the Department of Health and Social Care and the National Institute for Health Research, we temporarily paused the entry of new patients into the research studies that were taking place before the COVID-19 outbreak. This was to keep patients safe and to ensure that members of the research team were available to support clinical services and COVID-19 research.
Restarting research
Our efforts to tackle the pandemic continue but to advance care and treatment for East Lancashire patients across a range of health conditions, we are now restarting the research which was taking place prior to the COVID-19 outbreak. We are working closely with research sponsors to achieve this, and where clinical services are available for us to deliver the research.
Safety is our priority
The safety of patients and hospital staff is our top priority and we are following the Trust guidance for infection control and hospital appointments. This includes minimising footfall on the hospital site, maintaining social distancing and using decontamination procedures.
If you’re taking part in a research study
If you were taking part in a research study at the hospital before the COVID-19 outbreak, the study team will have contacted you to discuss any changes to your follow up appointments, or to your medication and how to collect this from the hospital. As we restart any research that was temporarily paused, the study team will continue to inform you of any changes that may affect you.
If you have any questions or concerns, please don’t hesitate to get in touch with your study team. Their contact details are as follows:
For women’s health research: 01282 803081
For children's research: 01254 736649
For cancer research: 01254 733299
For all other research: 01254 733687
To find out more about our research
If you’d like to find out more about research at East Lancashire Hospitals, please visit the research pages of this website or you can also follow us on twitter @ELHTresearch. The Be Part of Research website also provides more information on research and lists the studies taking place in East Lancashire and nationally throughout the NHS.
Information for researchers and sponsors
The restart of research, which was taking place in the Trust before the COVID-19 pandemic, is happening in a phased approach according to the prioritisation levels published in the National Institute for Health Research (NIHR) Restart Framework.
The prioritisation levels are as follows:
- Level 1: COVID studies with Urgent Public Health (UPH) status
- Level 2: Non-COVID studies where patient safety may be compromised in not continuing or re-opening
- Level 3: All other studies
Researchers:
Please contact the Research and Innovation Support Office about the restart of your research. Before deciding to restart your research at the Trust, please ensure:
- The continued viability of the research, including the impact of any amendments to the study protocol
- Whether clinical services are available within the Trust to continue supporting the research
- That all Trust infection control measures can be implemented to ensure the safety of participants and staff
Sponsors:
Please contact the Research and Innovation Support Office:
- For information on our response whilst dealing with the COVID-19 outbreak
- To discuss plans for restarting your research study within the Trust
- To discuss the ongoing management of your study at ELHT
- For advice relating to on-site monitoring visits during the pandemic
- If you’d like any further information about our research
COVID-19
For further information about these studies please contact the Research Support Office by calling 01254 733008.
|
Short title |
Description |
Status |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
| CCP UK | ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections | Open | Dr S Chukkambotla | Oxford University Hospitals NHS Trust | Study website |
| UKOSS | Pandemic Influenza in Pregnancy | Open | Ms S Loveridge | University of Oxford | Study website |
| RECOVERY | Randomised Evaluation of COVID-19 Therapy | Open | Dr S Chukkambotla | University of Oxford | Study website |
| REMAP-CAP | Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) | Open | Dr S Chukkambotla | University Medical Center Utrecht | Study website |
| GENOMICC | Genetics of Susceptibility and Mortality in Critical Care Study |
Open | Dr M Smith | University of Edinburgh and NHS Lothian Health Board | Study website |
| COVER | The impact of COVID-19 pandemic on the provision, practice and outcomes of vascular surgery | Open | Mr S Hardy | University Hospitals Coventry and Warwickshire NHS Trust | Study website |
| Pan-Covid | Pregnancy And Neonatal outcomes for women with Covid-19 | Open | Mrs B Hammond | Imperial College London | Study website |
| ATOMIC2 | A multi-centre open-label two-arm randomised superiority clinical trial of Azithromycin versus usual care In Ambulatory COVID-19 | Open | Dr R Garlapati | University of Oxford | Study website |
| UNITE COVID | European Society of Intensive Care Medicine COVID-19 Project | Open | Dr N Truman | Ghent University Hospital, Belgium | |
| CLARITY | Impact of biologic and immunomodulatory therapy on SARS-COV-2 infection and immunity in patients with inflammatory bowel disease | Open | Dr J Colllum | Royal Devon and Exeter NHS Foundation Trust | Be Part of Research |
Last updated 9th November 2020
Anaesthetics, pain and critical care
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
| ALLEGRO* | A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery | Prof A Krige | University of Edinburgh and NHS Lothian | ALLEGRO study website |
| CASAP* | Children's Acute Surgical Abdomen Programme | Dr I Clegg | University College London | |
| EFFORT* | The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial | Dr S Clarke | Queen's University at Kingston | |
| MET-REPAIR* | MET: REevaluation for Perioperative cArdIac Risk (MET-REPAIR): a prospective, multi–centre cohort observational study |
Dr S Chukkambotla | University of Leeds | |
| MET-REPAIR-FRAILTY* | MET-REPAIR-FRAILTY: Frailty substudy of MET: REevaluation for Perioperative cArdIac Risk | Dr S Chukkambotla | University of Leeds | |
|
PQIP* |
Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme |
Dr M Pollard |
University College London |
* Study restarted/open to recruitment
Last updated 9th November 2020
Cancer, including cancers of the blood
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of our cancer studies, please contact the cancer research team on 01254 733299.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
| ACE* | A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) | Dr Parikh | University Hospitals Bristol NHS Trust | |
| ACELARATE | A Phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with Gemcitabine in patient with metastatic pancreatic carcinoma. |
Dr Ferreira | The Clatterbridge Cancer Centre NHS Foundation Trust | |
| ATLANTIS* | An adaptive multi-arm phase II trial of maintenance targeted therapy after chemotherapy in metastatic urothelial cancer |
Dr Parikh | NHS Greater Glasgow & Clyde and the University of Glasgow | Cancer Research UK website |
| BC-Predict | Impact & acceptability of 10 year risk at breast cancer screening v1 | Mr R Dobrashian | Manchester University NHS Foundation Trust | Cancer Research UK website |
| CLOCS* |
Cancer Loyalty Card Study This study is recruiting women with ovarian cancer and healthy female volunteers. For further details please visit the CLOCS study website |
Dr Badea | Imperial College London | CLOCS study webpage |
| MAGNITUDE* | Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Subjects with Metastatic Prostate Cancer | Dr O Parikh | Janssen | |
| MOSES* | Evaluation of the role of tongue base MucOsectomy and Step sErial Sectioning in the management of the unknown primary squamous cell cancer in the head and neck | Miss N Ghazali | The Royal Marsden NHS Foundation Trust | Be Part of Research website |
| One-RCC* | Patient Reported Outcomes And Treatment Experiences In Renal Cell Carcinoma (One-RCC) | Dr O Parikh | Bristol-Myers Squibb International Corporation | |
| PATHOS* | A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer |
Miss N Ghazali | Velindre University NHS Trust & Cardiff University | Cancer Research UK website |
| Prevalence* | Biomarker Study to Determine Frequency of DNA-repair Defects in Men with Metastatic Prostate Cancer (Prevalence) | Dr O Parikh | Janssen | |
| PRIMETIME* | Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers: Breast cancer | Dr M Hogg | Institute of Cancer Research | Cancer Research UK website |
| PROTECTOR* | Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal | Mr M Willett | Queen Mary University of London | PROTECTOR study webpage |
| Q-ABC* | Quality of life After Bladder Cancer (Q-ABC): A comparison of patient related outcomes following radical surgery and radiotherapy | Dr O Parikh | Brighton and Sussex University Hospitals NHS Trust | SHORE-C website |
|
Rapper |
Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy |
Dr Charnley |
University of Manchester | NHS choices |
|
Stampede |
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy |
Dr O Parikh |
MRC Clinical Trials Unit at University College London | |
|
UKGPC study* |
UK Genetic Prostate Cancer Study |
Dr O Parikh |
The Institute of Cancer Research |
* Study restarted/open to recruitment
Last updated 1st December 2020
Child and adolescent mental health
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
| Early onset obsessive compulsive disorder | Dr D Mahadevan | University of Cambridge |
Diabetes, stroke, heart and blood vessel disease
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
| Address-2* | An incident and high risk type 1 diabetes research cohort – After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2) |
Diabetes | Dr Del Rio | Imperial College London | ADDRESS-2 study website |
| CODIFI2* | Randomised controlled trial of swab versus tissue sampling for infected diabetic foot ulcers, and comparison of culture versus molecular processing techniques | Diabetes | Ms J Lomax | University of Leeds | |
| DROPLET* | Defining The Rate Of Progression Of Late Onset Type 1 Diabetes | Diabetes | Dr S Ramtoola | Royal Devon and Exeter NHS Foundation Trust | |
| In-Range* | TOUJEO® and TRESIBA® in terms of glucose values in target range and variability during continuous glucose monitoring in patients with type 1 diabetes mellitus | Diabetes | Dr S Ramtoola | Sanofi | |
|
MYDIABETES* |
MODY in young-onset diabetes in different ethnicities |
Diabetes |
Dr S Ramtoola |
Imperial College of Science, Technology and Medicine | |
|
BRAINS |
British repository of DNA in stroke: towards the identification of new drug targets |
Stroke |
Dr N Goorah |
Imperial College Healthcare NHS Trust | |
| CONVINCE | COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke | Stroke | Dr A Singh | University College Dublin | |
| PRISM* | Purines for Rapid Identification of Stroke Mimics (PRISM): a diagnostic accuracy study | Stroke | C Curley | Northumbria Healthcare NHS Foundation Trust | |
| R4VAD | Rates, Risks and Routes to Reduce Vascular Dementia | Stroke | Sheeba Philip | NHS Lothian | |
| Orion-4* | A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease |
Heart and blood vessel | Dr Ramtoola | University of Oxford |
* Study restarted/open to recruitment
Last updated 9th November 2020
Digestive tract and liver
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
IBD BioResource* |
The UK inflammatory bowel disease bioresource: Progressing from genetics to function and clinical translation in Crohn's Disease & Ulcerative Colitis |
Crohn's disease |
Dr J Collum |
Cambridge University Hospital NHS Foundation Trust | |
| STATIC | STATIC – STopping Aminosalicylate Therapy in Inactive Crohn’s Disease (STATIC) Study: A Randomized, Open-label, Non-inferiority Trial | Crohn's disease | Dr J Collum | Robarts Clinical Trials Inc. | British Society of Gastroenterology website |
| Phase 2 dose-finding UC study | A 54-Week Treatment, Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo and Active-Controlled, Parallel-Group Phase 2 Study to Assess the Efficacy and Safety of Brazikumab in Participants with Moderately to Severely Active Ulcerative Colitis | Ulcerative Colitis | Dr J Collum | Allergan Limited |
* Study restarted/open to recruitment
Last updated 9th November 2020
Ear, nose and throat, infectious diseases, eyes and lungs
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
| BICS | A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease | Lung | Dr I Crossingham | University of Aberdeen/NHS Grampian | BICS study website |
|
EMBARC: European Bronchiectasis Registry |
The EMBARC European Bronchiectasis Registry |
Lung |
Dr I Crossingham |
NHS Tayside |
Last updated 13th January 2020
Skin, muscle, bone and connective tissue disorders
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
Dupuytren’s Interventions Surgery vs. Collagenase (DISC)* |
A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients |
Musculoskeletal |
Dr F Younis |
University Hospitals of Leicester NHS Trust | |
|
PREVENT-RA |
PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis |
Musculoskeletal |
Prof L Teh |
University of Manchester | |
|
TOXICITY FROM BIOLOGIC THERAPY (BSRBR)* |
Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis |
Musculoskeletal |
Prof L Teh |
University of Leeds | |
| UKIVAS | Development of a Pan UK Vasculitis Cohort to Analyse Variations in Disease Susceptibility and Outcomes | Musculoskeletal | Prof L Teh | University of Oxford | |
|
BADBIR* |
British Association of Dermatologists Biologic Interventions Register |
Skin |
Dr Owen |
University of Manchester | |
|
B-STOP |
A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis |
Skin |
Dr Owen |
Guy's and St Thomas' NHS Foundation Trust |
|
Last updated 9th November 2020
Surgery, injuries and emergencies
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
| ARTISAN | Acute Rehabilitation following Traumatic anterior shoulder dISlocAtioN (ARTISAN) - A Multi Centre RCT | Mr S Hadi/Rachel Dean | University of Warwick and University Hospitals Coventry & Warwickshire NHS Trust | ARTISAN study webpage |
| CIPHER* | UK cohort study to investigate the prevention of parastomal hernia | Mr L Jones | Royal Devon & Exeter NHS Foundation Trust | |
| MURALS Study | Comparing the musculoskeletal demands of surgeons performing Robotic-assisted Laparoscopic surgery and standard laparoscopic surgery | Mr D Subar | Lancaster University | |
| Panraman | New biomarker identification of pancreatic cancer to improve diagnosis | Mr D Subar | Lancaster University | |
|
PUrE |
The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT Percutaneous nephrolithotomy (PNL), flexible Ureterorenoscopy (FURS) and Extracorporeal lithotripsy (ESWL) for lower pole kidney stones |
Mr S Srirangam |
University of Aberdeen | |
| The Sunflower Study* | A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones | Mr D Subar | Leeds Teaching Hospitals NHS Trust | CTEU Bristol website |
| SUNRISE* | Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy Surgery |
Mr L Jones | University of Birmingham | Birmingham Clinical Trials Unit website |
* Study restarted/open to recruitment
Last updated 9th November 2020
Women, newborn and children’s research
You may need to talk to your doctor or midwife about taking part in the studies listed here.
If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact the women's health research team:
Burnley General Hospital: 01282 803081
Royal Blackburn Hospital: 01254 732650
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
BIOJUME* |
Biology of Juvenile Myoclonic Epilepsy |
Children |
Dr R Belderbos |
Kings College London | |
| CASAP* | Children's Acute Surgical Abdomen Programme | Children | Dr I Clegg | University College London | |
| CF Start* |
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial |
Children | Dr D Corbett | Alder Hey Childrens NHS FT | CF START website |
|
RaDaR |
National Studies of Rare Kidney Diseases |
Children |
Dr J Iqbal |
Medical Research Council | |
| REGAIN* | Rolandic Epilepsy Genomewide Association International Study (REGAIN) |
Children | Dr R Belderbos | King’s College London and King’s College Hospital NHS Trust | Childhood Epilepsy.org website |
| USTEKID* | Ustekinumab in adolescents with recent-onset type 1 diabetes | Children | Dr Gardner | Cardiff University | |
|
UK ITP registry* |
The UK Paediatric ITP Registry |
Children, |
Dr V Holme |
Royal Manchester Children's Hospital | |
| Address-2* | An incident and high risk type 1 diabetes research cohort – After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2) |
Children, diabetes | Dr Del Rio | Imperial College London | ADDRESS-2 website |
| OPTI-SURF* | Optimal surfactant delivery for preterm babies with respiratory distress syndrome.The effect of surfactant dose on outcomes in preterm infants with Respiratory Distress Syndrome |
Neonatal | Dr A Sur | Chiesi Limited | |
| Big baby trial* | Induction of labour for predicted macrosomia ‘The Big Baby Trial’ | Reproduction | Dr S Davies | University Hospitals Coventry and Warwickshire NHS Trust | UK Clinical Trials Gateway |
| CERM* | Chronic Endometritis and Recurrent Miscarriage - The CERM trial | Reproduction | F Clarke | University Hospitals Coventry and Warwickshire NHS Trust | Warwick Clinical Trials Unit website |
| CRAFT* | Cerclage after full dilatation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies | Reproduction | F Clarke | King's College London | |
|
C-STICH* |
The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH) |
Reproduction |
Mr Yen Eit Liew |
Birmingham Women's and Children's NHS Foundation Trust | |
| C-Stitch2* | Cervical Cerclage to Prevent Miscarriage and Preterm Birth - a Randomised Controlled Trial | Reproduction | Mr Yen Eit Liew | Birmingham Women's and Children's NHS Foundation Trust | Birmingham Clinical Trials Unit |
| FROSTTIE* | A randomised controlled trial of FRenotomy and breastfeeding support Or breastfeeding Support without frenotomy to investigate continuation of breastfeeding for babies with Tongue-TIE | Reproduction | B Hammond | University of Oxford | FROSTTIE study webpage |
|
GEM3* |
A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy |
Reproduction |
Ms F Clarke |
NHS Lothian | |
| LOCI* | Letrozole Or Clomifene for Ovulation Induction | Reproduction | Ms Nethra | University of Birmingham | |
| NAPES* | Neurodevelopment after prenatal exposure to seizures (NAPES) Study | Reproduction | The University of Manchester |
* Study restarted/open to recruitment
Last updated 1st December 2020
Finding research studies on the internet
Clinical research studies happening locally and nationally can be found by searching the following databases:
- Be part of research
- Join dementia research
- Research for the future (for patients with diabetes, heart, lung and kidney disease)
