Information for patients taking part in research

We're so grateful to all the East Lancashire patients who’ve volunteered to take part in health research. You join over 20,000 participants from our hospitals, who contribute to a better understanding of disease and finding new treatments.

Safety is our priority

The safety of patients and hospital staff is our top priority and we are following the Trust guidance for infection control and hospital appointments. This includes minimising footfall on the hospital site, maintaining social distancing and using decontamination procedures.

If you’re taking part in a research study

If you were taking part in a research study at the hospital before the COVID-19 outbreak, the study team will have contacted you to discuss any changes to your follow up appointments, or to your medication and how to collect this from the hospital. As we restart any research that was temporarily paused, the study team will continue to inform you of any changes that may affect you.

If you have any questions or concerns, please don’t hesitate to get in touch with your study team. Their contact details are as follows:

For women’s health research: 01282 803081
For children's research: 01254 732643
For cancer research: 01254 733299
For all other research: 01254 732756

To find out more about our research 

If you’d like to find out more about research at East Lancashire Hospitals, please visit the research pages of this website or you can also follow us on twitter @ELHTresearch. The Be Part of Research website also provides more information on research and lists the studies taking place in East Lancashire and nationally throughout the NHS.

You can find out more about our response to the COVID-19 pandemic here.

COVID-19

For further information about these studies please contact the Research Support Office by calling 01254 732756.

Short title

Description

Status

Local Researcher

Sponsor

Find out more

ISARIC ISARIC/WHO Coronavirus Clinical Characterisation Protocol for Severe Emerging Infections Open Dr S Chukkambotla Oxford University Hospitals NHS Trust Study website
RECOVERY  Randomised Evaluation of COVID-19 Therapy Open Dr S Chukkambotla University of Oxford Study website
REMAP-CAP Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) Open Dr Nick Truman University Medical Center Utrecht Study website
GENOMICC Genetics of Susceptibility and Mortality in
Critical Care
Study
Open Dr M Smith University of Edinburgh and NHS Lothian Health Board Study website
SINEPOST study SARS-CoV-2 Infection in NEonates or in Pregnancy: Outcomes at EighTeen months Open Mrs B Hammond University of Bristol Study website

* Study not open to new participants at ELHT (Temporary pause due to COVID 19)

Last updated 20th January 2022

Anaesthetics, pain and critical care

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Further information

ALLEGRO A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery Prof A Krige University of Edinburgh and NHS Lothian ALLEGRO study website
CASAP Children's Acute Surgical Abdomen Programme Dr I Clegg University College London  

PQIP

Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme

Dr M Pollard

University College London

PQIP website

VITDALIZE Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency
The UK arm of an International Multi-Centre, Placebo-Controlled, Phase III Double-Blind trial
Dr Anton Krige  University of Birmingham University of Birmingham
MOSAICC  Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administered for critically ill patients with acute kidney injury and metabolic acidosis Dr Matthew  Smith University Hospitals of  Derby and Burton NHS Foundation Triust  

* Study not open to new participants at ELHT (Temporary pause)

Last updated 29th March 2022

Cancer, including cancers of the blood

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of our cancer studies, please contact the cancer research team on 01254 733299.

Short title

Description

Local researcher

Sponsor

Find out more

ACE A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) Dr Parikh University Hospitals Bristol NHS Trust  
ACELARATE* A Phase III, open label, multicentre randomised clinical study
comparing Acelarin (NUC-1031) with Gemcitabine in patient
with metastatic pancreatic carcinoma.
 
Dr Ferreira The Clatterbridge Cancer Centre NHS Foundation Trust  
CLOCS*

Cancer Loyalty Card Study

This study is recruiting women with ovarian cancer and healthy female volunteers. For further details please visit the CLOCS study website

Dr Badea Imperial College London CLOCS study webpage
PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant
treatment in patients undergoing transoral surgery for Human
papillomavirus (HPV)-positive oropharyngeal cancer
Mr K Panayiotis Velindre University NHS Trust & Cardiff University Cancer Research UK website
Prevalence Biomarker Study to Determine Frequency of DNA-repair Defects in Men with Metastatic Prostate Cancer (Prevalence) Dr O Parikh Janssen  
PROTECTOR Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal Mr M Willett  Queen Mary University of London PROTECTOR study webpage

Rapper*

Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy

Dr Charnley

University of Manchester NHS choices

Stampede*

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy

Dr O Parikh

MRC Clinical Trials Unit at University College London

Cancer Research UK website

UKGPC study

UK Genetic Prostate Cancer Study

Dr O Parikh

The Institute of Cancer Research

The Institute of Cancer Research website

Cancer Research UK website

POETIC-A PreOperative Endocrine Therapy for Individualised Care with Abemaciclib Miss C Yip The Institute of Cancer Research The Institute of Cancer Research website

 

* Study not open to new participants at ELHT (Temporary pause)

Last updated 1st April 2022

Child and adolescent mental health

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

Short title

Description

Local researcher

Sponsor

Further information

Glycopy Bromide A study to assess utilisation and safety of Glycopyrronium Bromide 1mg/5ml Oral Solution as licensed for symptomatic treatment of severe sialorrhoea in children and adolescents aged 3 years and older with chronic neurological disorders in the UK Dr Vanessa Holme DSRU Education and Research Limited  
CRAFFT Children’s Radius - Acute Fracture Fixation Trial: A multi-centre prospective randomised non-inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children Dr Fizan Younis University of Oxford https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/crafft

* Study not open to new participants at ELHT (Temporary pause)

 Last updated: 11th January 2022

Diabetes, stroke, heart and blood vessel disease

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local Researcher

Sponsor

Find out more

Address-2 An incident and high risk type 1 diabetes research cohort –
After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2)
Diabetes Dr Del Rio Imperial College London ADDRESS-2 study website
DROPLET Defining The Rate Of Progression Of Late Onset Type 1 Diabetes Diabetes Dr S Ramtoola Royal Devon and Exeter NHS Foundation Trust https://www.diabetesgenes.org/current-research/droplet/

BRAINS

British repository of DNA in stroke: towards the identification of new drug targets

Stroke

Dr N Goorah 

Imperial College Healthcare NHS Trust

The BRAINS study website

CONVINCE COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke Stroke Dr A Singh University College Dublin https://www.uclan.ac.uk/research/activity/convince
Orion-4 A double-blind randomized placebo-controlled trial assessing
the effects of inclisiran on clinical outcomes among people with
atherosclerotic cardiovascular disease
Heart and blood vessel Dr Ramtoola University of Oxford https://www.ctsu.ox.ac.uk/research/orion-4
RECREATE A multicentre cluster randomised controlled trial evaluating the clinical and cost-effectiveness of an intervention to reduce sedentary behaviour in stroke survivors incorporating an internal pilot phase and embedded process evaluation Stroke Samantha Hancock Bradford Teaching Hospitals NHS Foundation Trust Bradford Teaching Hosptals NHS Foundation Trust website
L-HARP Liverpool Heart and Brain Project Stroke Sheeba Philip University of Liverpool https://www.lhch.nhs.uk/research/clinical-trials-unit/contributing-to-clinical-research/

EVAREST

The use of Blood Biomarkers, including extracellular vesicles to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram Cardiovascular Sanjay Banypersad University of Oxford https://www.rdm.ox.ac.uk/about/our-clinical-facilities-and-mrc-units/cardiovascular-clinical-research-facility/evarest-1/about-evarest
iCorMicA International study of Coronary Microvascular Angina (iCorMicA): a randomised, controlled, multicentre trial and registry Cardiovascular Dr Balachandran NHS Greater Glasgow and Clyde Healthboard Clinical Trials.gov website

* Study not open to new participants at ELHT (Temporary pause)

Last updated 15th March 2022

Digestive tract and liver

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

IBD BioResource

The UK inflammatory bowel disease bioresource: Progressing from genetics to function and clinical translation in Crohn's Disease & Ulcerative Colitis

Crohn's disease

Dr J Collum

Cambridge University Hospital NHS Foundation Trust

IBD BioResource webpage

STATIC STATIC – STopping Aminosalicylate Therapy in Inactive Crohn’s Disease (STATIC) Study: A Randomized, Open-label, Non-inferiority Trial Crohn's disease Dr J Collum Robarts Clinical Trials Inc. British Society of Gastroenterology website
Phase 2 dose-finding UC study* A 54-Week Treatment, Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo and Active-Controlled, Parallel-Group Phase 2 Study to Assess the Efficacy and Safety of Brazikumab in Participants with Moderately to Severely Active Ulcerative Colitis Ulcerative Colitis Dr J Collum Allergan Limited  
CATHETER II Randomised Controlled Trial CompAring THE Clinical And CosT-Effectiveness Of VaRious Washout Policies Versus No Washout Policy In Preventing Catheter Associated Complications In Adults Living With Long-Term Catheters Renal Dr S Srirangham NHS Grampian University of Aberdeen

* Study not open to new participants at ELHT (Temporary pause)

Last updated 13th May 2022

Ear, nose and throat, infectious diseases, eyes and lungs

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

BICS* A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease Lung Dr I Crossingham University of Aberdeen/NHS Grampian BICS study website
POPT Assessing Post-Operative bleeding, pain and return to work following Tonsillectomy ENT

Melissa

Kelly

Wrightington, Wigan and Leigh NHS Foundation Trust   
SAVER Sodium Valproate for Epigenetic Reprogramming in the Management of High Risk Oral Epithelial Dysplasia Oral and Dental Health Mr K Panayiotis University of Liverpool https://livrepository.liverpool.ac.uk/3130119/
BESRA
Brolucizumab Treatment Experience Study of Patients with Neovascular Age-related Macular Degeneration (nAMD) in UK routine clinical practice (BESRA)
Opthalmology Miss Salwa Abugreen Novartis https://www.novartis.com/clinicaltrials

* Study not open to new participants at ELHT (Temporary pause)

Last updated 13th May 2022

Skin, muscle, bone and connective tissue disorders

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

Sponsor

Find out more

         

 

BADBIR

British Association of  Dermatologists Biologic Interventions Register

Skin

Dr Owen

University of Manchester

BADBIR study website

B-STOP

A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis

Skin

Dr Owen

Guy's and St Thomas' NHS Foundation Trust

 

PREVENT RA PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis Muskoskeletal Prof L S Teh University of Manchester Prevent RA

* Study not open to new participants at ELHT (Temporary pause)

Last updated 23rd February 2022

Surgery, injuries and emergencies

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

Sponsor

Find out more

Panraman New biomarker identification of pancreatic cancer to improve diagnosis Mr D Subar Lancaster University  
The Sunflower Study A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones Mr D Subar Leeds Teaching Hospitals NHS Trust CTEU Bristol website
Recurrance after Whipple's (RAW) An international multi-centre retrospective cohort study investigating factors affecting cancer recurrence following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, ampullary adenocarcinoma and distal bile duct cholangiocarcinoma Miss A Kausar University of Southampton NHS Trust National Institute for Health Research
UK-ROX Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. Dr N Truman Intensive Care National Audit & Research Centre ICNARC website
SPECS A mechanistic trial comparing standard care versus prehabilitation in patients undergoing elective HPB and colorectal cancer surgery: a feasibility study Dr Joel Lambert East Lancashire Hospitals NHS Trust  

* Study not open to new participants at ELHT (Temporary pause)

Last updated 13th May 2022

Women, newborn and children’s research

You may need to talk to your doctor or midwife about taking part in the studies listed here.

If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact the women's health research team:

Burnley General Hospital: 01282 803081

Royal Blackburn Hospital: Women's health: 01254 732650; Children's research: 01254 732643.

Short title

Description

Patient group

Local Researcher

Sponsor

Find out more

BIOJUME

Biology of Juvenile Myoclonic Epilepsy 

Children

Dr R Belderbos

Kings College London

Childhood Epilepsy website

CASAP Children's Acute Surgical Abdomen Programme Children Dr I Clegg University College London  
CF Start

The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial

Children Dr D Corbett Alder Hey Childrens NHS FT CF START website
REGAIN Rolandic Epilepsy Genomewide Association International Study
(REGAIN)
Children Dr R Belderbos King’s College London and King’s College Hospital NHS Trust Childhood Epilepsy.org website

UK ITP registry

The UK Paediatric ITP Registry

Children,

Dr V Holme

Royal Manchester Children's Hospital

UK Paediatric ITP Working Party website

Address-2 An incident and high risk type 1 diabetes research cohort –
After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2)
Children, diabetes Dr Del Rio Imperial College London ADDRESS-2 website
Big baby trial Induction of labour for predicted macrosomia ‘The Big Baby Trial’ Reproduction Dr S Davies University Hospitals Coventry and Warwickshire NHS Trust UK Clinical Trials Gateway
CERM Chronic Endometritis and Recurrent Miscarriage - The CERM trial Reproduction F Clarke University Hospitals Coventry and Warwickshire NHS Trust Warwick Clinical Trials Unit website
CRAFT Cerclage after full dilatation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies Reproduction F Clarke King's College London  
C-Stich2 Cervical Cerclage to Prevent Miscarriage and Preterm Birth - a Randomised Controlled Trial Reproduction Mr Yen Eit Liew Birmingham Women's and Children's NHS Foundation Trust Birmingham Clinical Trials Unit
LOCI Letrozole Or Clomifene for Ovulation Induction Reproduction Ms Nethra University of Birmingham  
The Parrot-2 Trial Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia Reproduction Mr Maher King's College London Parrot-2 website
Tommys Rainbow The Tommy's National Rainbow Clinic Study Children Mr Maher The University of Manchester https://www.tommys.org/

ESPRIT 2

 

 

 

A multi-centre randomised controlled trial to determine the effectiveness of laparoscopic removal of isolated
superficial peritoneal endometriosis for the management of chronic pelvic pain in women: ESPriT2
Reproduction Mr Aty The University of Edinburgh https://www.ed.ac.uk/centre-reproductive-health/exppect-endometriosis/research/esprit
Giant Panda Pregnancy ANtihypertensive Drugs: which Agent is best? Reproduction Dr Davies University of Birmingham https://www.birmingham.ac.uk/research/bctu/trials/womens/giantpanda/index.aspx
FACT4CHILD Folic Acid Clinical Trial: Follow up of children

Children

Heather Collier Ottawa Hospital, Canada https://clinicaltrials.gov/ct2/show/NCT03269110
PURSUIT Proper Understanding of Recurrent Stress Urinary Incontinence Treatment in Women: A Randomised Controlled Trial of Endoscopic and Surgical Treatment Womens Dr S Cox North Bristol NHS Trust Pursuit North Bristol NHS Trust
REGAL Study Recurrence of Endometriosis: A randomised controlled trial of clinical and cost-effectiveness of Gonadotrophin Releasing Hormone Analogues with add-back hormone replacement therapy versus repeat Laparoscopic surgery(REGAL trial) Reproduction Mr Aty University of Aberdeen University of Aberdeen
GBS3
The clinical and cost-effectiveness of testing for Group B Streptococcus: a cluster randomised trial with economic and acceptability evaluations (GBS3)
Reproduction Dr Justine Nugent University of Nottingham https://www.gbs3trial.ac.uk/home.aspx

* Study not open to new participants at ELHT (Temporary pause)

Last updated 19th May 2022

Finding research studies on the internet

Clinical research studies happening locally and nationally can be found by searching the following databases: