The clinical research studies currently available to patients at East Lancashire Hospitals NHS Trust are listed below:
Anaesthetics and pain
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
| ALLEGRO | A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery | Prof A Krige | University of Edinburgh and NHS Lothian | ALLEGRO study website |
|
ASCRIBED |
The impact of Acute Systematic inflammation upon cerebrospinal fluid and blood Biomarkers of brain inflammation and injury in Dementia: a study in acute hip fracture patients |
Dr A Shannon |
University of East Anglia |
|
|
PQIP |
Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme |
Dr M Pollard |
University College London |
Last checked 7th May 2019
Cancer, including cancers of the blood
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of our cancer studies, please contact the cancer research team on 01254 733299.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
| ACE | A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) | Dr Parikh | University Hospitals Bristol NHS Trust | |
| ACELARATE | A Phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with Gemcitabine in patient with metastatic pancreatic carcinoma. |
Dr Ferreira | The Clatterbridge Cancer Centre NHS Foundation Trust | Pancreatic Cancer UK website |
| ATLANTIS | An adaptive multi-arm phase II trial of maintenance targeted therapy after chemotherapy in metastatic urothelial cancer |
Dr Parikh | NHS Greater Glasgow & Clyde and the University of Glasgow | Cancer Research UK website |
| CIPHER | UK cohort study to investigate the prevention of parastomal hernia | Mr L Jones | Royal Devon & Exeter NHS Foundation Trust | UK Clinical Trials Gateway |
| MAGNITUDE | Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Subjects with Metastatic Prostate Cancer | Dr O Parikh | Janssen | |
| Q-ABC | Quality of life After Bladder Cancer (Q-ABC): A comparison of patient related outcomes following radical surgery and radiotherapy | Dr O Parikh | Brighton and Sussex University Hospitals NHS Trust | SHORE-C website |
|
RAIDER |
A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder |
Dr O Parikh |
Institute of Cancer Research | |
|
Rapper |
Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy |
Dr Charnley |
University of Manchester | NHS choices |
|
Stampede |
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy |
Dr O Parikh |
Medical Research Council | |
|
UKGPC study |
UK Genetic Prostate Cancer Study |
Dr O Parikh |
The Institute of Cancer Research |
Last updated 5th August 2019
Child and adolescent mental health
Critical care
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Further information |
|---|---|---|---|---|
|
PQIP |
Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme |
Dr M Pollard |
University College London | |
|
The REST study |
Protective ventilation with veno-venous lung assist in respiratory failure |
Dr S Chukkambotla |
Belfast Health & Social Care Trust |
|
Last checked 7th May 2019
Diabetes, stroke, heart and blood vessel disease
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
| CODIFI2 | Randomised controlled trial of swab versus tissue sampling for infected diabetic foot ulcers, and comparison of culture versus molecular processing techniques | Diabetes | Ms J Lomax | University of Leeds | |
|
MYDIABETES |
MODY in young-onset diabetes in different ethnicities |
Diabetes |
Dr S Ramtoola |
Imperial College of Science, Technology and Medicine | |
|
StartRight |
Getting the right classification and treatment from diagnosis in young adults with diabetes |
Diabetes |
Dr S Ramtoola |
Royal Devon and Exeter NHS Foundation Trust | |
|
ATAM - Developing and validating a therapeutic alliance measure |
Aphasia Therapeutic Alliance Measure (ATAM): Development and preliminary psychometric evaluation |
Stroke |
Catherine Curley |
University of Manchester |
|
|
BRAINS |
British repository of DNA in stroke: towards the identification of new drug targets |
Stroke |
Dr N Goorah |
Imperial College Healthcare NHS Trust | |
| CONVINCE | COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke | Stroke | Dr A Singh | University College Dublin | |
| R4VAD | Rates, Risks and Routes to Reduce Vascular Dementia | Stroke | Sheeba Philip | NHS Lothian | |
|
LLIFT |
Pilot study to test the clinical efficacy of FlowOx™ home treatment compared to standard care in patients with critical limb ischemia and lower limb ulcers |
Blood vessels |
Mr Simon Hardy |
University of Salford |
|
| EVAREST | The use of blood biomarkers, including extracellular vesicles, to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram | Heart | Dr Sanjay Banypersad | University of Oxford | The EVAREST study webpage |
| MASTER DAPT | MAnagement of high bleeding risk patients post bioresorbable polymer coated STEnt implantation with an abbReviated versus prolonged DAPT regimen | Heart | Dr J McDonald | European Cardiovascular Research Institute (ECRI) | ECRI study webpage |
| SFLEX2 | Prospective Evaluation of Thin-Strut Biodegradable Polymer-coated Supraflex Sirolimus-Eluting Stents in an All-comers Patient Population (S-FLEX UK-II) | Heart | Prof S Garg | Sahajanand Medical Technologies Pvt. Ltd | |
|
UK GRIS |
Effectiveness of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome |
Heart |
Prof S Garg |
University of Leeds |
Last updated 15th July 2019
Ear, nose and throat, infectious diseases, eyes and lungs
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
Characterisation of subretinal hyper-reflective material in nAMD |
The characterisation of subretinal hyper-reflective material using Heidelberg Optical Coherence Tomography and Heidelberg Multicolour imaging in neovascular age-related macular degeneration |
Eyes |
Dr Z Al-Moasseb |
East Lancashire Hospitals NHS Trust |
|
|
Stereotactic radiotherapy for wet AMD (STAR) |
StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): A randomised, double-masked, sham-controlled, clinical trial comparing low-voltage X-ray irradiation with as needed ranibizumab, to as needed ranibizumab monotherapy |
Eyes |
Mrs S Abugreen |
Kings College London | |
| BICS | A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease | Lung | Dr I Crossingham | University of Aberdeen/NHS Grampian | BICS study website |
|
EMBARC: European Bronchiectasis Registry |
The EMBARC European Bronchiectasis Registry |
Lung |
Dr I Crossingham |
NHS Tayside |
Last checked 16th May 2019
Skin, muscle, bone and connective tissue disorders
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Patient group |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
BILAG-2004 VALIDATION |
Validation of BILAG2004 index for assessment of disease activity in systemic lupus erythematosus |
Musculoskeletal |
Prof L Teh |
|
|
|
Dupuytren’s Interventions Surgery vs. Collagenase (DISC) |
A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients |
Musculoskeletal |
Dr F Younis |
University Hospitals of Leicester NHS Trust | |
|
GRASP |
GRASP: Getting it Right: Addressing Shoulder Pain. Clinical and cost effectiveness of progressive exercise compared to best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: a 2x2 factorial randomised controlled trial |
Musculoskeletal |
Dr A Hallett, Helen Thompson |
University of Oxford | |
|
PREVENT-RA |
PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis |
Musculoskeletal |
Prof L Teh |
University of Manchester | |
|
TOXICITY FROM BIOLOGIC THERAPY (BSRBR) |
Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis |
Musculoskeletal |
Prof L Teh |
University of Leeds | |
|
BADBIR |
British Association of Dermatologists Biologic Interventions Register |
Skin |
Dr Owen |
University of Manchester | |
|
B-STOP |
A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis |
Skin |
Dr Owen |
Guy's and St Thomas' NHS Foundation Trust |
|
Last checked 7th May 2019
Surgery
You may need to talk to your doctor about taking part in the studies listed here.
If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.
|
Short title |
Description |
Local researcher |
Sponsor |
Find out more |
|---|---|---|---|---|
|
DRAFFT 2 |
DRAFFT 2: Distal Radius Acute Fracture Fixation Trial - A Randomised Controlled Trial of Manipulation and surgical fixation with K-wires versus Manipulation and Casting in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius |
Mr M Srinivasan |
University of Oxford | |
|
PPAC2 - Packing of Perianal Abscess Cavities 2 |
The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial |
Miss J Smith |
Manchester University NHS Foundation Trust | |
|
PUrE |
The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT Percutaneous nephrolithotomy (PNL), flexible Ureterorenoscopy (FURS) and Extracorporeal lithotripsy (ESWL) for lower pole kidney stones |
Mr S Srirangam |
University of Aberdeen | |
| The Sunflower Study | A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones | Mr D Subar | Leeds Teaching Hospitals NHS Trust | CTEU Bristol website |
| SUNRISE | Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy Surgery |
Mr L Jones | University of Birmingham | Birmingham Clinical Trials Unit website |
Last updated 25th July 2019
Women, newborn and children’s research
You may need to talk to your doctor or midwife about taking part in the studies listed here.
If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.
For information about any of these studies, please contact the women's health research team:
Burnley General Hospital: 01282 803081
Royal Blackburn Hospital: 01254 732650
|
Short title |
Description |
Patient group |
Local Researcher |
Sponsor |
Find out more |
|---|---|---|---|---|---|
|
BIOJUME |
Biology of Juvenile Myoclonic Epilepsy |
Children |
Dr R Belderbos |
Kings College London | |
| CF Start |
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial |
Children | Dr D Corbett | Alder Hey Childrens NHS FT | CF START website |
|
EU Patch |
EU Patch: The role of glasses wearing in amblyopia treatment |
Children |
Mrs M Mohan |
University of Leicester | |
|
RaDaR |
National Studies of Rare Kidney Diseases |
Children |
Dr J Iqbal |
Medical Research Council | |
| REGAIN | Rolandic Epilepsy Genomewide Association International Study (REGAIN) |
Children | Dr R Belderbos | King’s College London and King’s College Hospital NHS Trust | Childhood Epilepsy.org website |
|
UK ITP registry |
The UK Paediatric ITP Registry |
Children, |
Dr V Holme |
Royal Manchester Children's Hospital | |
|
Trialnet (pathway to prevention study) |
Natural history study of the development of type I diabetes, phase 1, 2 and 3 |
Children, diabetes |
Dr C Gardner |
University of Bristol | |
|
BabyOSCAR |
Outcome after Selective early treatment for Closure of patent ductus ARteriosus in pre-term babies |
Neonatal |
Dr N Soni |
University of Oxford | |
| OPTISURF | The effect of surfactant dose on outcomes in preterm infants with Respiratory Distress Syndrome |
Neonatal | Dr D Kumar | Chiesi UK Limited | The Leeds Teaching Hospitals NHS Trust website |
| Better care pathways in pregnancies after stillbirth | Reproduction | Cathie Melvin | The University of Manchester | UK Clinical Trials Gateway | |
| Big baby trial | Induction of labour for predicted macrosomia ‘The Big Baby Trial’ | Reproduction | Dr S Davies | University Hospitals Coventry and Warwickshire NHS Trust | UK Clinical Trials Gateway |
|
C-STICH |
The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH) |
Reproduction |
Mrs E Martindale |
Birmingham Women's and Children's NHS Foundation Trust | |
| C-Stitch2 | Cervical Cerclage to Prevent Miscarriage and Preterm Birth - a Randomised Controlled Trial | Reproduction | Mrs E Martindale | Birmingham Women's and Children's NHS Foundation Trust | Birmingham Clinical Trials Unit |
| FROSTTIE | A randomised controlled trial of FRenotomy and breastfeeding support Or breastfeeding Support without frenotomy to investigate continuation of breastfeeding for babies with Tongue-TIE | Reproduction | Mrs Schram | University of Oxford | FROSTTIE study webpage |
|
GEM3 |
A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy |
Reproduction |
Dr F Clarke |
NHS Lothian | |
| MifeMiso | A randomised, placebo-controlled trial of mifepristone and misoprostol versus misoprostol alone in the medical management of missed miscarriage | Reproduction | Mrs K Bhatia | University of Birmingham | Birmingham Clinical Trials Unit website |
| NAPES | Neurodevelopment after prenatal exposure to seizures (NAPES) Study | Reproduction | Mrs Schram | The University of Manchester | |
|
PIP |
Pipelle for pregnancy (PIP) studies |
Reproduction |
Mrs S Nethra |
Auckland District Health Board (New Zealand) |
|
|
PREP |
Helping Pregnant smokers to quit: A multi-centre RCT of electronic cigarettes vs. nicotine patches (usual care) |
Reproduction |
Mr M Maher |
Queen Mary University of London |
|
| UCON | Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action |
Reproduction | Mrs K Bhatia | University of Edinburgh and NHS Lothian | Birmingham Clinical Trials Unit |
Last updated 3rd June 2019
Finding research studies on the internet
Clinical research studies happening locally and nationally can be found by searching the following databases:
- Be part of research
- Join dementia research
- Research for the future (for patients with diabetes, heart, lung and kidney disease)
