COVID-19 research at ELHT

Health research is vital as we face the COVID-19 pandemic. At East Lancashire Hospitals NHS Trust (ELHT) and many other NHS organisations across the UK, research studies looking into COVID-19 are taking place. The research is helping us to learn more about the illness, which people are most at risk, and what treatments benefit those affected. 

Clinical and research staff at East Lancashire Hospitals are playing their part. Within days we organized the set-up of national, high-priority research studies within our hospitals, so that East Lancashire patients could take part in the research. Our efforts continue, with more East Lancashire patients joining the research each week.

For an up to date summary of the national priority COVID-19 studies available, please check the list below:

Research into other conditions

We're so grateful to all the East Lancashire patients who’ve volunteered to take part in health research. You join over 20,000 participants from our hospitals, who contribute to a better understanding of disease and finding new treatments.

In accordance with guidelines from the Department of Health and Social Care and the National Institute for Health Research, we temporarily paused the entry of new patients into the research studies that were taking place before the COVID-19 outbreak. This was to ensure that members of the research team were available to support clinical services and COVID-19 research.

We’re now looking at restarting this research activity, working closely with research sponsors and our clinical services to assess how best to achieve this, with safety as our top priority.

If you’re already taking part in a research study

If you were taking part in a research study at the hospital before the COVID-19 outbreak, the study team will have contacted you to discuss any changes to your follow up appointments, or to your medication and how to collect this from the hospital. As we restart any research that was temporarily paused, the study team will continue to contact participants to inform you of any changes. If you have any questions or concerns, please don’t hesitate to get in touch with your study team. Their contact details are as follows:

For women’s health research: 01282 803081
For children's research: 01254 736649
For cancer research: 01254 733299
For all other research: 01254 733687

To find out more about our research 

If you’d like to find out more about research at East Lancashire Hospitals, please visit the research pages of this website. You can also follow us on twitter @ELHTresearch. The Be Part of Research website provides more information on research and lists the studies taking place in East Lancashire and nationally throughout the NHS.

Research sponsors

If you’d like any information about our research, our response whilst dealing with the COVID-19 outbreak, our plans for restarting research activity within the Trust, or would like to discuss the ongoing management of your study at ELHT, please contact the Research Support Office. 
 

COVID-19

For further information about these studies please contact the Research Support Office by calling 01254 733008.

Short title

Description

Status

Local Researcher

 Sponsor

Find out more
CCP UK ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections Open Dr S Chukkambotla Oxford University Hospitals NHS Trust Study website
UKOSS Pandemic Influenza in Pregnancy  Open Ms S Loveridge University of Oxford Study website
RECOVERY  Randomised Evaluation of COVID-19 Therapy Open Dr S Chukkambotla University of Oxford Study website
ImmunoCOVID19 study

Dear parent/young person, we are doing an online study about coronavirus infection in children who have a condition that make them more vulnerable to infections or are taking medication that affects their immune system. For further information please email: immunoCOVID19study@elht.nhs.uk

 Open Dr J Iqbal University Hospitals Southampton Study website
REMAP-CAP Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) Open Dr S Chukkambotla University Medical Center Utrecht Study website
GENOMICC Genetics of Susceptibility and Mortality in
Critical Care
Study		 Open Dr M Smith University of Edinburgh and NHS Lothian Health Board Study website
COVER The impact of COVID-19 pandemic on the provision, practice and outcomes of vascular surgery Open Mr S Hardy University Hospitals Coventry and Warwickshire NHS Trust Study website
Pan-Covid Pregnancy And Neonatal outcomes for women with Covid-19 Open Mrs B Hammond Imperial College London Study website
ATOMIC2  A multi-centre open-label two-arm randomised superiority clinical trial of Azithromycin versus usual care In Ambulatory COVID-19 Open Dr R Garlapati University of Oxford Study website
UNITE COVID European Society of Intensive Care Medicine COVID-19 Project Open Dr N Truman Ghent University Hospital, Belgium  

Last updated 6th July 2020

Anaesthetics, pain and critical care

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

 Sponsor

Further information
ALLEGRO A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery Prof A Krige University of Edinburgh and NHS Lothian ALLEGRO study website
CASAP Children's Acute Surgical Abdomen Programme Dr I Clegg University College London  
EFFORT  The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial Dr S Clarke Queen's University at Kingston  
MET-REPAIR MET: REevaluation for Perioperative cArdIac Risk
(MET-REPAIR): a prospective, multi–centre cohort
observational study		 Dr S Chukkambotla  University of Leeds  
MET-REPAIR-FRAILTY MET-REPAIR-FRAILTY: Frailty substudy of MET: REevaluation for Perioperative cArdIac Risk  Dr S Chukkambotla University of Leeds  

PQIP

Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme

Dr M Pollard

 University College London

PQIP website

 Last updated 13th January 2020

Cancer, including cancers of the blood

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of our cancer studies, please contact the cancer research team on 01254 733299.

Short title

Description

Local researcher

 Sponsor

Find out more
ACE A Phase IV study to evaluate cognitive function in metastatic castrate resistant prostate cancer (mCRPC) patients treated with Abiraterone Acetate + Prednisolone (AAP) or Enzalutamide (ENZ) Dr Parikh University Hospitals Bristol NHS Trust  
ACELARATE A Phase III, open label, multicentre randomised clinical study
comparing Acelarin (NUC-1031) with Gemcitabine in patient
with metastatic pancreatic carcinoma.
 		 Dr Ferreira The Clatterbridge Cancer Centre NHS Foundation Trust Pancreatic Cancer UK website
ATLANTIS An adaptive multi-arm phase II trial of maintenance targeted therapy after
chemotherapy in metastatic urothelial cancer		 Dr Parikh NHS Greater Glasgow & Clyde and the University of Glasgow Cancer Research UK website
CIPHER* UK cohort study to investigate the prevention of parastomal hernia Mr L Jones Royal Devon & Exeter NHS Foundation Trust UK Clinical Trials Gateway
MAGNITUDE Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Subjects with Metastatic Prostate Cancer Dr O Parikh Janssen  
MOSES Evaluation of the role of tongue base MucOsectomy and Step sErial Sectioning in the management of the unknown primary squamous cell cancer in the head and neck Miss N Ghazali The Royal Marsden NHS Foundation Trust Be Part of Research website
PROTECTOR Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal Mr M Willett  Queen Mary University of London PROTECTOR study webpage
Q-ABC Quality of life After Bladder Cancer (Q-ABC): A comparison of patient related outcomes following radical surgery and radiotherapy Dr O Parikh Brighton and Sussex University Hospitals NHS Trust SHORE-C website

Rapper

Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy

Dr Charnley

 University of Manchester NHS choices

Stampede

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy

Dr O Parikh

 MRC Clinical Trials Unit at University College London

Cancer Research UK website

UKGPC study

UK Genetic Prostate Cancer Study

Dr O Parikh

 The Institute of Cancer Research

The Institute of Cancer Research website

Cancer Research UK website

* Study restarted/open to recruitment

Last checked 7th July 2020

Child and adolescent mental health

Diabetes, stroke, heart and blood vessel disease

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local Researcher

 Sponsor

Find out more
Address-2* An incident and high risk type 1 diabetes research cohort –
After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2)		 Diabetes Dr Del Rio Imperial College London ADDRESS-2 study website
CODIFI2* Randomised controlled trial of swab versus tissue sampling for infected diabetic foot ulcers, and comparison of culture versus molecular processing techniques Diabetes Ms J Lomax University of Leeds  
DROPLET Defining The Rate Of Progression Of Late Onset Type 1 Diabetes Diabetes Dr S Ramtoola Royal Devon and Exeter NHS Foundation Trust  

MYDIABETES

 MODY in young-onset diabetes in different ethnicities

Diabetes

Dr S Ramtoola

 Imperial College of Science, Technology and Medicine

My DIABETES study webpage

StartRight

 Getting the right classification and treatment from diagnosis in young adults with diabetes

Diabetes

Dr S Ramtoola

 Royal Devon and Exeter NHS Foundation Trust

StartRight study webpage

BRAINS

British repository of DNA in stroke: towards the identification of new drug targets

Stroke

Dr N Goorah 

 Imperial College Healthcare NHS Trust

The BRAINS study website
CONVINCE COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke Stroke Dr A Singh University College Dublin  
R4VAD Rates, Risks and Routes to Reduce Vascular Dementia Stroke Sheeba Philip NHS Lothian  
EVAREST The use of blood biomarkers, including extracellular vesicles, to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram Heart Dr Sanjay Banypersad University of Oxford The EVAREST study webpage

* Study restarted/open to recruitment

Last updated 23rd June 2020

Digestive tract and liver

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

 Sponsor

Find out more

IBD BioResource

 The UK inflammatory bowel disease bioresource: Progressing from genetics to function and clinical translation in Crohn's Disease & Ulcerative Colitis

Crohn's disease

Dr J Collum

 Cambridge University Hospital NHS Foundation Trust

IBD BioResource webpage
STATIC STATIC – STopping Aminosalicylate Therapy in Inactive Crohn’s Disease (STATIC) Study: A Randomized, Open-label, Non-inferiority Trial Crohn's disease Dr J Collum Robarts Clinical Trials Inc. British Society of Gastroenterology website

Last updated 13th January 2020

Ear, nose and throat, infectious diseases, eyes and lungs

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

 Sponsor

Find out more
BICS A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease Lung Dr I Crossingham University of Aberdeen/NHS Grampian BICS study website

EMBARC: European Bronchiectasis Registry

The EMBARC European Bronchiectasis Registry

Lung

Dr I Crossingham

 NHS Tayside

EMBARC website

Last updated 13th January 2020

Skin, muscle, bone and connective tissue disorders

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Patient group

Local researcher

 Sponsor

Find out more

BILAG-2004 VALIDATION

Validation of BILAG2004 index for assessment of disease activity in systemic lupus erythematosus

Musculoskeletal

Prof L Teh

  

 

Dupuytren’s Interventions Surgery vs. Collagenase (DISC)

A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients

Musculoskeletal

Dr F Younis

 University Hospitals of Leicester NHS Trust

UK Clinical Trials Gateway

PREVENT-RA

PRe-clinical EValuation of Novel Targets in RA (PREVeNT RA): A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to Evaluate Predictors of the Development of Rheumatoid Arthritis

Musculoskeletal

Prof L Teh

 University of Manchester

PREVeNT RA website

TOXICITY FROM BIOLOGIC THERAPY (BSRBR)

Prospective observational study of the long term hazards of anti-TNF therapy in rheumatoid arthritis

Musculoskeletal

Prof L Teh

 University of Leeds

University of Manchester BSRBR-RA study website
UKIVAS  Development of a Pan UK Vasculitis Cohort to Analyse Variations in Disease Susceptibility and Outcomes Musculoskeletal Prof L Teh University of Oxford  

BADBIR

British Association of  Dermatologists Biologic Interventions Register

Skin

Dr Owen

 University of Manchester

BADBIR study website

B-STOP

A multicentre, prospective, cohort study to establish clinically relevant pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis

Skin

Dr Owen

 Guy's and St Thomas' NHS Foundation Trust

 

Last updated 10th March 2020

Surgery, injuries and emergencies

You may need to talk to your doctor about taking part in the studies listed here.

If you’re already taking part in a research study but can't see it listed here, the study may be closed to recruitment. All the patients that the researchers needed to include, will have been entered into the study. But for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact our research team on 01254 732651 or 01254 733213.

Short title

Description

Local researcher

 Sponsor

Find out more
ARTISAN  Acute Rehabilitation following Traumatic anterior shoulder dISlocAtioN (ARTISAN) - A Multi Centre RCT Mr S Hadi/Rachel Dean University of Warwick and University Hospitals Coventry & Warwickshire NHS Trust ARTISAN study webpage

DRAFFT 2

DRAFFT 2: Distal Radius Acute Fracture Fixation Trial - A Randomised Controlled Trial of Manipulation and surgical fixation with K-wires versus Manipulation and Casting in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius

Mr M Srinivasan

 University of Oxford

University of Oxford website

PPAC2 -  Packing of Perianal Abscess Cavities 2

The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial

Miss J Smith

 Manchester University NHS Foundation Trust

North West Research Collaborative website

PUrE

The clinical and cost effectiveness of surgical interventions for stones in the lower kidney: The PUrE RCT Percutaneous nephrolithotomy (PNL), flexible Ureterorenoscopy (FURS) and Extracorporeal lithotripsy (ESWL) for lower pole kidney stones

Mr S Srirangam

 University of Aberdeen

PUrE study website
The Sunflower Study A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones Mr D Subar Leeds Teaching Hospitals NHS Trust CTEU Bristol website
SUNRISE Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy
Surgery		 Mr L Jones University of Birmingham Birmingham Clinical Trials Unit website

Last updated 15th October 2019

Women, newborn and children’s research

You may need to talk to your doctor or midwife about taking part in the studies listed here.

If you’re already taking part in a research study and it is not listed here, the study may be closed to recruitment. This means that all the patients that the researchers needed to include, have been entered into the study. However, for patients already taking part, study treatment and the collection of research data will continue.

For information about any of these studies, please contact the women's health research team:

Burnley General Hospital: 01282 803081

Royal Blackburn Hospital: 01254 732650

Short title

Description

Patient group

Local Researcher

 Sponsor

Find out more

BIOJUME

Biology of Juvenile Myoclonic Epilepsy 

Children

Dr R Belderbos

 Kings College London

Childhood Epilepsy website
CASAP Children's Acute Surgical Abdomen Programme Children Dr I Clegg University College London  
CF Start*

The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial

 Children Dr D Corbett Alder Hey Childrens NHS FT CF START website

RaDaR

National Studies of Rare Kidney Diseases

Children

Dr J Iqbal

 Medical Research Council

Rare Renal website
REGAIN Rolandic Epilepsy Genomewide Association International Study
(REGAIN)		 Children Dr R Belderbos King’s College London and King’s College Hospital NHS Trust Childhood Epilepsy.org website

UK ITP registry

The UK Paediatric ITP Registry

Children,

Dr V Holme

 Royal Manchester Children's Hospital

UK Paediatric ITP Working Party website
Address-2* An incident and high risk type 1 diabetes research cohort –
After Diabetes Diagnosis REsearch Support System-2 (ADDRESS-2)		 Children, diabetes Dr Del Rio Imperial College London ADDRESS-2 website

Trialnet (pathway to prevention study)

Natural history study of the development of type I diabetes, phase 1, 2 and 3

Children, diabetes

Dr C Gardner

 University of Bristol

Trialnet study website

BabyOSCAR

Outcome after Selective early treatment for Closure of patent ductus ARteriosus in pre-term babies

Neonatal

Dr N Soni

 University of Oxford

National Perinatal Epidemiology Unit website
OPTI-SURF* Optimal surfactant delivery for preterm babies with
respiratory distress syndrome.The effect of surfactant dose on
outcomes in preterm infants with Respiratory Distress
Syndrome		 Neonatal Dr A Sur Chiesi Limited  
Big baby trial Induction of labour for predicted macrosomia ‘The Big Baby Trial’ Reproduction Dr S Davies University Hospitals Coventry and Warwickshire NHS Trust UK Clinical Trials Gateway
CRAFT Cerclage after full dilatation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies Reproduction F Clarke King's College London  

C-STICH*

The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH)

Reproduction

Mr Yen Eit Liew

 Birmingham Women's and Children's NHS Foundation Trust

Birmingham Clinical Trials Unit
C-Stitch2 Cervical Cerclage to Prevent Miscarriage and Preterm Birth - a Randomised Controlled Trial Reproduction Mr Yen Eit Liew Birmingham Women's and Children's NHS Foundation Trust Birmingham Clinical Trials Unit
FROSTTIE A randomised controlled trial of FRenotomy and breastfeeding support Or breastfeeding Support without frenotomy to investigate continuation of breastfeeding for babies with Tongue-TIE Reproduction Mrs Schram University of Oxford  FROSTTIE study webpage

GEM3*

A double blind placebo controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy

Reproduction

Ms F Clarke

 NHS Lothian

Birmingham Clinical Trials Unit
NAPES Neurodevelopment after prenatal exposure to seizures (NAPES) Study Reproduction Mrs Schram The University of Manchester  

* Study restarted/open to recruitment

Last updated 7th July 2020

Finding research studies on the internet

Clinical research studies happening locally and nationally can be found by searching the following databases: